GSM6881266

Dataset: gse221521 • Sample: Control group RNA278 • Status: Healthy control
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Quality Control Metrics

12,662,711 Total counts Group median: 12,762,148 • 51.6%ile (≈ Median)
25,853 Detected genes Group median: 2,606 • 29.8%ile (≈ Median)
4 Mitochondrial fraction (%) Group median: 6 • 11.1%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

46.1Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.19
bar=donor   line=cohort median 		0.17 57.8%
FOXO3 Insulin/IGF-1 Signaling 18.07
bar=donor   line=cohort median 		12.92 86.3%
CETP Lipid Metabolism 0.39
bar=donor   line=cohort median 		0.40 47.9%
SIRT6 Sirtuin Family 3.67
bar=donor   line=cohort median 		3.67 50.0%
SIRT1 Sirtuin Family 3.54
bar=donor   line=cohort median 		3.48 55.7%
SIRT3 Sirtuin Family 0.53
bar=donor   line=cohort median 		1.10 0.8%
IGF1R Insulin/IGF-1 Signaling 5.37
bar=donor   line=cohort median 		4.33 67.6%
KLOTHO Anti-aging 0.06
bar=donor   line=cohort median 		0.06 44.8%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.13
bar=donor   line=cohort median 		0.07 81.1%
TERT Telomere Maintenance 0.02
bar=donor   line=cohort median 		0.01 56.7%
IRS2 Insulin/IGF-1 Signaling 50.20
bar=donor   line=cohort median 		35.28 73.3%
TP53 Tumor Suppression 2.40
bar=donor   line=cohort median 		3.83 7.5%
SHC1 Signal Transduction 6.81
bar=donor   line=cohort median 		8.77 4.9%
ACE Signal Transduction 0.15
bar=donor   line=cohort median 		0.39 8.0%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 11,940.5 86,637
2 FTL ENSG00000087086 protein_coding 6,283.9 69,306
3 MT-CO1 ENSG00000198804 protein_coding 5,577.5 108,905
4 MT-CO2 ENSG00000198712 protein_coding 5,163.8 44,725
5 MT-RNR2 ENSG00000210082 Mt_rRNA 4,713.6 93,052
6 MT-CO3 ENSG00000198938 protein_coding 4,117.0 40,872
7 MT-ND1 ENSG00000198888 protein_coding 3,096.5 37,485
8 MT-ND4 ENSG00000198886 protein_coding 2,805.9 48,961
9 MT-RNR1 ENSG00000211459 Mt_rRNA 2,421.1 29,248
10 TMSB4XP8 ENSG00000187653 processed_pseudogene 2,419.5 4,136

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,250.0
bar=donor   line=cohort median 		1,535.8 1,385.4 41.2%
2 S100A9 protein_coding 11,940.5
bar=donor   line=cohort median 		10,851.3 9,235.1 68.7%
3 IL1B protein_coding 5.4
bar=donor   line=cohort median 		5.6 6.1 44.8%
4 CXCL8 protein_coding 645.2
bar=donor   line=cohort median 		220.4 207.4 94.0%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.4
bar=donor   line=cohort median 		1.7 2.4 25.6%
6 FCGR3B protein_coding 240.7
bar=donor   line=cohort median 		145.0 129.3 87.3%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,064.5
bar=donor   line=cohort median 		709.1 706.2 75.9%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 40.6
bar=donor   line=cohort median 		66.1 56.4 24.6%
9 CD3E protein_coding 33.9
bar=donor   line=cohort median 		37.6 37.7 38.6%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 4.0
bar=donor   line=cohort median 		3.1 3.1 72.3%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 279.5
bar=donor   line=cohort median 		302.3 281.6 49.5%
12 GNLY protein_coding 50.4
bar=donor   line=cohort median 		80.1 70.7 27.2%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 458.5
bar=donor   line=cohort median 		598.7 582.1 40.2%
14 HBA1 protein_coding 1,327.4
bar=donor   line=cohort median 		2,133.6 1,960.7 36.5%
15 HBA2 protein_coding 591.5
bar=donor   line=cohort median 		1,142.2 1,083.5 29.3%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 5,577.5
bar=donor   line=cohort median 		6,862.1 6,938.4 23.6%
17 MT-CO2 protein_coding 5,163.8
bar=donor   line=cohort median 		6,023.6 5,810.8 32.4%
18 MT-ND1 protein_coding 3,096.5
bar=donor   line=cohort median 		3,656.3 3,718.2 28.2%
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