GSM6881267

Dataset: gse221521 • Sample: DM group RNA288 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

13,209,006 Total counts Group median: 12,709,871 • 70.2%ile (≈ Median)
26,329 Detected genes Group median: 2,638 • 44.3%ile (≈ Median)
4 Mitochondrial fraction (%) Group median: 6 • 12.7%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

62.4Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.12
bar=donor   line=cohort median 		0.17 38.6%
FOXO3 Insulin/IGF-1 Signaling 17.40
bar=donor   line=cohort median 		12.92 81.1%
CETP Lipid Metabolism 0.29
bar=donor   line=cohort median 		0.40 24.1%
SIRT6 Sirtuin Family 2.43
bar=donor   line=cohort median 		3.67 6.5%
SIRT1 Sirtuin Family 6.65
bar=donor   line=cohort median 		3.48 97.7%
SIRT3 Sirtuin Family 1.41
bar=donor   line=cohort median 		1.10 87.8%
IGF1R Insulin/IGF-1 Signaling 6.00
bar=donor   line=cohort median 		4.33 77.5%
KLOTHO Anti-aging 0.17
bar=donor   line=cohort median 		0.06 93.0%
APOC3 Lipid Metabolism 0.10
bar=donor   line=cohort median 		0.00 99.2%
IL6 Inflammation 0.20
bar=donor   line=cohort median 		0.07 87.3%
TERT Telomere Maintenance 0.01
bar=donor   line=cohort median 		0.01 41.2%
IRS2 Insulin/IGF-1 Signaling 24.51
bar=donor   line=cohort median 		35.28 26.2%
TP53 Tumor Suppression 4.62
bar=donor   line=cohort median 		3.83 70.2%
SHC1 Signal Transduction 8.16
bar=donor   line=cohort median 		8.77 28.8%
ACE Signal Transduction 0.56
bar=donor   line=cohort median 		0.39 76.9%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-CO1 ENSG00000198804 protein_coding 8,371.0 170,502
2 S100A9 ENSG00000163220 protein_coding 6,212.1 47,018
3 MT-RNR2 ENSG00000210082 Mt_rRNA 5,557.8 114,451
4 MT-CO2 ENSG00000198712 protein_coding 4,058.6 36,669
5 MT-CO3 ENSG00000198938 protein_coding 3,931.0 40,709
6 RPL13AP5 ENSG00000236552 processed_pseudogene 3,530.7 28,542
7 EEF1A1P5 ENSG00000196205 processed_pseudogene 3,379.1 61,997
8 FTL ENSG00000087086 protein_coding 3,294.7 37,906
9 MT-ND4 ENSG00000198886 protein_coding 2,853.4 51,938
10 RPS28P7 ENSG00000227097 processed_pseudogene 2,834.6 7,863

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 800.7
bar=donor   line=cohort median 		1,568.6 1,385.4 14.2%
2 S100A9 protein_coding 6,212.1
bar=donor   line=cohort median 		10,144.6 9,235.1 23.6%
3 IL1B protein_coding 13.5
bar=donor   line=cohort median 		6.9 6.1 88.9%
4 CXCL8 protein_coding 1,143.9
bar=donor   line=cohort median 		225.8 207.4 99.7%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.8
bar=donor   line=cohort median 		2.2 2.4 39.1%
6 FCGR3B protein_coding 141.5
bar=donor   line=cohort median 		157.0 129.3 53.6%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,646.7
bar=donor   line=cohort median 		802.6 706.2 93.5%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 78.5
bar=donor   line=cohort median 		56.8 56.4 74.4%
9 CD3E protein_coding 45.3
bar=donor   line=cohort median 		36.9 37.7 68.7%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 5.8
bar=donor   line=cohort median 		3.2 3.1 88.3%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 106.3
bar=donor   line=cohort median 		296.3 281.6 3.9%
12 GNLY protein_coding 38.2
bar=donor   line=cohort median 		77.5 70.7 14.2%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 424.4
bar=donor   line=cohort median 		509.6 582.1 37.6%
14 HBA1 protein_coding 1,539.0
bar=donor   line=cohort median 		1,931.5 1,960.7 38.6%
15 HBA2 protein_coding 360.1
bar=donor   line=cohort median 		1,068.0 1,083.5 13.7%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 8,371.0
bar=donor   line=cohort median 		7,011.1 6,938.4 73.3%
17 MT-CO2 protein_coding 4,058.6
bar=donor   line=cohort median 		5,968.9 5,810.8 12.7%
18 MT-ND1 protein_coding 1,683.1
bar=donor   line=cohort median 		3,670.4 3,718.2 4.4%
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