GSM6881268

Dataset: gse221521 • Sample: DM group RNA29 • Status: Diabetes mellitus without diabetic retinopathy
◂ Prev All Donors Next ▸

Quality Control Metrics

13,588,018 Total counts Group median: 12,709,871 • 79.5%ile (↑ High)
25,215 Detected genes Group median: 2,638 • 15.3%ile (↓ Low)
4 Mitochondrial fraction (%) Group median: 6 • 15.8%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

49.8Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.08
bar=donor   line=cohort median 		0.17 21.0%
FOXO3 Insulin/IGF-1 Signaling 15.34
bar=donor   line=cohort median 		12.92 67.1%
CETP Lipid Metabolism 0.38
bar=donor   line=cohort median 		0.40 45.9%
SIRT6 Sirtuin Family 2.29
bar=donor   line=cohort median 		3.67 6.0%
SIRT1 Sirtuin Family 5.62
bar=donor   line=cohort median 		3.48 95.6%
SIRT3 Sirtuin Family 0.74
bar=donor   line=cohort median 		1.10 7.5%
IGF1R Insulin/IGF-1 Signaling 6.80
bar=donor   line=cohort median 		4.33 86.8%
KLOTHO Anti-aging 0.14
bar=donor   line=cohort median 		0.06 86.3%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.00
bar=donor   line=cohort median 		0.07 10.4%
TERT Telomere Maintenance 0.02
bar=donor   line=cohort median 		0.01 53.1%
IRS2 Insulin/IGF-1 Signaling 25.49
bar=donor   line=cohort median 		35.28 31.4%
TP53 Tumor Suppression 5.63
bar=donor   line=cohort median 		3.83 87.8%
SHC1 Signal Transduction 8.49
bar=donor   line=cohort median 		8.77 39.6%
ACE Signal Transduction 0.45
bar=donor   line=cohort median 		0.39 59.8%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 8,771.3 185,808
2 TMSB4XP8 ENSG00000187653 processed_pseudogene 7,360.0 13,501
3 S100A9 ENSG00000163220 protein_coding 7,063.1 54,993
4 MT-CO1 ENSG00000198804 protein_coding 6,034.4 126,438
5 HBA1 ENSG00000206172 protein_coding 3,926.1 91,758
6 MT-CO2 ENSG00000198712 protein_coding 3,842.1 35,709
7 FTL ENSG00000087086 protein_coding 3,726.1 44,099
8 RPS28P7 ENSG00000227097 processed_pseudogene 3,408.1 9,725
9 H3P6 ENSG00000235655 processed_pseudogene 3,263.2 18,224
10 MT-CO3 ENSG00000198938 protein_coding 3,155.5 33,616

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,224.6
bar=donor   line=cohort median 		1,568.6 1,385.4 39.1%
2 S100A9 protein_coding 7,063.1
bar=donor   line=cohort median 		10,144.6 9,235.1 31.9%
3 IL1B protein_coding 10.3
bar=donor   line=cohort median 		6.9 6.1 78.5%
4 CXCL8 protein_coding 660.8
bar=donor   line=cohort median 		225.8 207.4 94.6%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 0.7
bar=donor   line=cohort median 		2.2 2.4 8.5%
6 FCGR3B protein_coding 224.5
bar=donor   line=cohort median 		157.0 129.3 85.2%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 466.2
bar=donor   line=cohort median 		802.6 706.2 23.1%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 66.6
bar=donor   line=cohort median 		56.8 56.4 64.5%
9 CD3E protein_coding 47.6
bar=donor   line=cohort median 		36.9 37.7 73.8%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 7.1
bar=donor   line=cohort median 		3.2 3.1 92.0%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 219.0
bar=donor   line=cohort median 		296.3 281.6 28.8%
12 GNLY protein_coding 59.6
bar=donor   line=cohort median 		77.5 70.7 37.0%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 1,349.7
bar=donor   line=cohort median 		509.6 582.1 83.2%
14 HBA1 protein_coding 3,926.1
bar=donor   line=cohort median 		1,931.5 1,960.7 73.3%
15 HBA2 protein_coding 1,054.6
bar=donor   line=cohort median 		1,068.0 1,083.5 47.4%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 6,034.4
bar=donor   line=cohort median 		7,011.1 6,938.4 31.3%
17 MT-CO2 protein_coding 3,842.1
bar=donor   line=cohort median 		5,968.9 5,810.8 9.6%
18 MT-ND1 protein_coding 2,161.1
bar=donor   line=cohort median 		3,670.4 3,718.2 8.5%
◂ Previous Donor Back to Donor List Next Donor ▸