GSM6881269

Dataset: gse221521 • Sample: Control group RNA292 • Status: Healthy control
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Quality Control Metrics

12,293,738 Total counts Group median: 12,762,148 • 36.5%ile (≈ Median)
26,073 Detected genes Group median: 2,606 • 36.5%ile (≈ Median)
4 Mitochondrial fraction (%) Group median: 6 • 15.3%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

44.8Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.09
bar=donor   line=cohort median 		0.17 26.7%
FOXO3 Insulin/IGF-1 Signaling 16.78
bar=donor   line=cohort median 		12.92 76.9%
CETP Lipid Metabolism 0.44
bar=donor   line=cohort median 		0.40 60.4%
SIRT6 Sirtuin Family 2.69
bar=donor   line=cohort median 		3.67 10.1%
SIRT1 Sirtuin Family 2.84
bar=donor   line=cohort median 		3.48 21.0%
SIRT3 Sirtuin Family 0.88
bar=donor   line=cohort median 		1.10 15.8%
IGF1R Insulin/IGF-1 Signaling 6.44
bar=donor   line=cohort median 		4.33 80.6%
KLOTHO Anti-aging 0.21
bar=donor   line=cohort median 		0.06 96.6%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.00
bar=donor   line=cohort median 		0.07 10.4%
TERT Telomere Maintenance 0.03
bar=donor   line=cohort median 		0.01 70.2%
IRS2 Insulin/IGF-1 Signaling 32.35
bar=donor   line=cohort median 		35.28 44.8%
TP53 Tumor Suppression 3.62
bar=donor   line=cohort median 		3.83 43.3%
SHC1 Signal Transduction 7.77
bar=donor   line=cohort median 		8.77 14.3%
ACE Signal Transduction 0.40
bar=donor   line=cohort median 		0.39 52.6%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 11,920.3 83,970
2 MT-CO1 ENSG00000198804 protein_coding 7,362.4 139,568
3 MT-CO2 ENSG00000198712 protein_coding 5,075.4 42,679
4 MT-RNR2 ENSG00000210082 Mt_rRNA 4,389.9 84,136
5 FTL ENSG00000087086 protein_coding 4,176.5 44,721
6 MT-CO3 ENSG00000198938 protein_coding 4,034.4 38,885
7 MT-ND4 ENSG00000198886 protein_coding 3,398.4 57,571
8 RPL13AP5 ENSG00000236552 processed_pseudogene 2,933.5 22,071
9 MT-ND4L ENSG00000212907 protein_coding 2,903.4 10,601
10 MT-ATP8 ENSG00000228253 protein_coding 2,881.6 7,333

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,662.1
bar=donor   line=cohort median 		1,535.8 1,385.4 59.3%
2 S100A9 protein_coding 11,920.3
bar=donor   line=cohort median 		10,851.3 9,235.1 67.6%
3 IL1B protein_coding 9.0
bar=donor   line=cohort median 		5.6 6.1 72.3%
4 CXCL8 protein_coding 410.6
bar=donor   line=cohort median 		220.4 207.4 82.1%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 2.0
bar=donor   line=cohort median 		1.7 2.4 42.7%
6 FCGR3B protein_coding 211.7
bar=donor   line=cohort median 		145.0 129.3 81.1%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,358.1
bar=donor   line=cohort median 		709.1 706.2 87.8%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 48.9
bar=donor   line=cohort median 		66.1 56.4 37.0%
9 CD3E protein_coding 34.4
bar=donor   line=cohort median 		37.6 37.7 41.2%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.4
bar=donor   line=cohort median 		3.1 3.1 30.8%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 146.9
bar=donor   line=cohort median 		302.3 281.6 12.2%
12 GNLY protein_coding 45.6
bar=donor   line=cohort median 		80.1 70.7 22.5%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 138.2
bar=donor   line=cohort median 		598.7 582.1 7.0%
14 HBA1 protein_coding 601.3
bar=donor   line=cohort median 		2,133.6 1,960.7 11.1%
15 HBA2 protein_coding 153.4
bar=donor   line=cohort median 		1,142.2 1,083.5 2.3%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 7,362.4
bar=donor   line=cohort median 		6,862.1 6,938.4 57.8%
17 MT-CO2 protein_coding 5,075.4
bar=donor   line=cohort median 		6,023.6 5,810.8 29.3%
18 MT-ND1 protein_coding 2,421.8
bar=donor   line=cohort median 		3,656.3 3,718.2 12.2%
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