GSM6881271

Dataset: gse221521 • Sample: DM group RNA295 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

14,935,456 Total counts Group median: 12,709,871 • 91.5%ile (↑ High)
26,927 Detected genes Group median: 2,638 • 63.5%ile (≈ Median)
5 Mitochondrial fraction (%) Group median: 6 • 22.5%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

51.0Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.16
bar=donor   line=cohort median 		0.17 49.0%
FOXO3 Insulin/IGF-1 Signaling 14.87
bar=donor   line=cohort median 		12.92 63.5%
CETP Lipid Metabolism 0.43
bar=donor   line=cohort median 		0.40 58.3%
SIRT6 Sirtuin Family 4.57
bar=donor   line=cohort median 		3.67 84.2%
SIRT1 Sirtuin Family 2.59
bar=donor   line=cohort median 		3.48 12.2%
SIRT3 Sirtuin Family 1.03
bar=donor   line=cohort median 		1.10 38.6%
IGF1R Insulin/IGF-1 Signaling 2.31
bar=donor   line=cohort median 		4.33 22.5%
KLOTHO Anti-aging 0.06
bar=donor   line=cohort median 		0.06 46.9%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.23
bar=donor   line=cohort median 		0.07 90.9%
TERT Telomere Maintenance 0.01
bar=donor   line=cohort median 		0.01 39.6%
IRS2 Insulin/IGF-1 Signaling 27.94
bar=donor   line=cohort median 		35.28 37.1%
TP53 Tumor Suppression 3.45
bar=donor   line=cohort median 		3.83 36.5%
SHC1 Signal Transduction 8.56
bar=donor   line=cohort median 		8.77 42.2%
ACE Signal Transduction 0.97
bar=donor   line=cohort median 		0.39 95.1%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 18,069.3 154,637
2 MT-CO1 ENSG00000198804 protein_coding 6,888.7 158,651
3 MT-RNR2 ENSG00000210082 Mt_rRNA 6,294.7 146,569
4 MT-CO3 ENSG00000198938 protein_coding 5,404.1 63,279
5 MT-CO2 ENSG00000198712 protein_coding 4,759.0 48,617
6 FTL ENSG00000087086 protein_coding 4,074.7 53,007
7 MT-ND3 ENSG00000198840 protein_coding 4,002.0 20,681
8 MT-ND4 ENSG00000198886 protein_coding 3,147.4 64,777
9 MT-ND1 ENSG00000198888 protein_coding 3,133.1 44,736
10 EEF1A1P5 ENSG00000196205 processed_pseudogene 2,807.7 58,247

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,971.5
bar=donor   line=cohort median 		1,568.6 1,385.4 74.9%
2 S100A9 protein_coding 18,069.3
bar=donor   line=cohort median 		10,144.6 9,235.1 91.5%
3 IL1B protein_coding 8.2
bar=donor   line=cohort median 		6.9 6.1 68.1%
4 CXCL8 protein_coding 393.7
bar=donor   line=cohort median 		225.8 207.4 80.1%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.1
bar=donor   line=cohort median 		2.2 2.4 20.5%
6 FCGR3B protein_coding 250.5
bar=donor   line=cohort median 		157.0 129.3 88.9%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,412.7
bar=donor   line=cohort median 		802.6 706.2 88.9%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 64.4
bar=donor   line=cohort median 		56.8 56.4 61.4%
9 CD3E protein_coding 32.9
bar=donor   line=cohort median 		36.9 37.7 34.5%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 15.1
bar=donor   line=cohort median 		3.2 3.1 97.7%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 149.4
bar=donor   line=cohort median 		296.3 281.6 13.2%
12 GNLY protein_coding 23.3
bar=donor   line=cohort median 		77.5 70.7 4.9%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 126.5
bar=donor   line=cohort median 		509.6 582.1 6.0%
14 HBA1 protein_coding 605.5
bar=donor   line=cohort median 		1,931.5 1,960.7 11.7%
15 HBA2 protein_coding 370.2
bar=donor   line=cohort median 		1,068.0 1,083.5 14.2%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 6,888.7
bar=donor   line=cohort median 		7,011.1 6,938.4 47.4%
17 MT-CO2 protein_coding 4,759.0
bar=donor   line=cohort median 		5,968.9 5,810.8 22.0%
18 MT-ND1 protein_coding 3,133.1
bar=donor   line=cohort median 		3,670.4 3,718.2 30.3%
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