GSM6881272

Dataset: gse221521 • Sample: Control group RNA298 • Status: Healthy control
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Quality Control Metrics

11,593,449 Total counts Group median: 12,762,148 • 17.4%ile (↓ Low)
25,378 Detected genes Group median: 2,606 • 17.4%ile (↓ Low)
4 Mitochondrial fraction (%) Group median: 6 • 10.1%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

49.3Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.30
bar=donor   line=cohort median 		0.17 81.6%
FOXO3 Insulin/IGF-1 Signaling 19.89
bar=donor   line=cohort median 		12.92 95.1%
CETP Lipid Metabolism 0.18
bar=donor   line=cohort median 		0.40 7.0%
SIRT6 Sirtuin Family 4.63
bar=donor   line=cohort median 		3.67 85.8%
SIRT1 Sirtuin Family 3.14
bar=donor   line=cohort median 		3.48 32.4%
SIRT3 Sirtuin Family 0.76
bar=donor   line=cohort median 		1.10 8.0%
IGF1R Insulin/IGF-1 Signaling 1.92
bar=donor   line=cohort median 		4.33 17.4%
KLOTHO Anti-aging 0.08
bar=donor   line=cohort median 		0.06 56.2%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.00
bar=donor   line=cohort median 		0.07 10.4%
TERT Telomere Maintenance 0.01
bar=donor   line=cohort median 		0.01 47.9%
IRS2 Insulin/IGF-1 Signaling 136.87
bar=donor   line=cohort median 		35.28 99.7%
TP53 Tumor Suppression 2.92
bar=donor   line=cohort median 		3.83 18.9%
SHC1 Signal Transduction 8.63
bar=donor   line=cohort median 		8.77 45.9%
ACE Signal Transduction 0.65
bar=donor   line=cohort median 		0.39 85.2%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 14,799.8 98,316
2 FTL ENSG00000087086 protein_coding 5,732.4 57,885
3 MT-CO1 ENSG00000198804 protein_coding 5,320.7 95,118
4 MT-RNR2 ENSG00000210082 Mt_rRNA 4,867.8 87,981
5 MT-CO2 ENSG00000198712 protein_coding 4,688.8 37,182
6 MT-CO3 ENSG00000198938 protein_coding 4,151.7 37,736
7 MT-ND4 ENSG00000198886 protein_coding 2,909.4 46,480
8 MT-ND1 ENSG00000198888 protein_coding 2,836.5 31,438
9 H3P6 ENSG00000235655 processed_pseudogene 2,831.1 13,490
10 MT-ATP8 ENSG00000228253 protein_coding 2,636.8 6,328

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 2,253.9
bar=donor   line=cohort median 		1,535.8 1,385.4 81.6%
2 S100A9 protein_coding 14,799.8
bar=donor   line=cohort median 		10,851.3 9,235.1 81.6%
3 IL1B protein_coding 6.5
bar=donor   line=cohort median 		5.6 6.1 54.7%
4 CXCL8 protein_coding 476.9
bar=donor   line=cohort median 		220.4 207.4 87.8%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 3.0
bar=donor   line=cohort median 		1.7 2.4 62.4%
6 FCGR3B protein_coding 119.1
bar=donor   line=cohort median 		145.0 129.3 42.2%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,206.0
bar=donor   line=cohort median 		709.1 706.2 83.7%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 47.5
bar=donor   line=cohort median 		66.1 56.4 33.9%
9 CD3E protein_coding 28.2
bar=donor   line=cohort median 		37.6 37.7 21.5%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 0.5
bar=donor   line=cohort median 		3.1 3.1 0.8%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 279.3
bar=donor   line=cohort median 		302.3 281.6 49.0%
12 GNLY protein_coding 79.9
bar=donor   line=cohort median 		80.1 70.7 56.2%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 672.0
bar=donor   line=cohort median 		598.7 582.1 56.2%
14 HBA1 protein_coding 1,626.3
bar=donor   line=cohort median 		2,133.6 1,960.7 41.2%
15 HBA2 protein_coding 1,073.7
bar=donor   line=cohort median 		1,142.2 1,083.5 48.4%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 5,320.7
bar=donor   line=cohort median 		6,862.1 6,938.4 17.9%
17 MT-CO2 protein_coding 4,688.8
bar=donor   line=cohort median 		6,023.6 5,810.8 21.0%
18 MT-ND1 protein_coding 2,836.5
bar=donor   line=cohort median 		3,656.3 3,718.2 21.0%
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