GSM6881273

Dataset: gse221521 • Sample: DM group RNA3 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

10,587,540 Total counts Group median: 12,709,871 • 7.5%ile (↓ Low)
26,614 Detected genes Group median: 2,638 • 55.4%ile (≈ Median)
6 Mitochondrial fraction (%) Group median: 6 • 59.3%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

42.7Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.17 4.9%
FOXO3 Insulin/IGF-1 Signaling 15.71
bar=donor   line=cohort median 		12.92 71.8%
CETP Lipid Metabolism 0.29
bar=donor   line=cohort median 		0.40 26.2%
SIRT6 Sirtuin Family 3.16
bar=donor   line=cohort median 		3.67 22.5%
SIRT1 Sirtuin Family 5.36
bar=donor   line=cohort median 		3.48 93.0%
SIRT3 Sirtuin Family 1.41
bar=donor   line=cohort median 		1.10 88.3%
IGF1R Insulin/IGF-1 Signaling 2.98
bar=donor   line=cohort median 		4.33 32.9%
KLOTHO Anti-aging 0.04
bar=donor   line=cohort median 		0.06 35.5%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.02
bar=donor   line=cohort median 		0.07 25.7%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 42.45
bar=donor   line=cohort median 		35.28 60.9%
TP53 Tumor Suppression 4.20
bar=donor   line=cohort median 		3.83 60.4%
SHC1 Signal Transduction 7.98
bar=donor   line=cohort median 		8.77 20.0%
ACE Signal Transduction 0.28
bar=donor   line=cohort median 		0.39 30.8%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-CO1 ENSG00000198804 protein_coding 8,336.5 136,101
2 MT-CO2 ENSG00000198712 protein_coding 7,458.8 54,016
3 MT-RNR2 ENSG00000210082 Mt_rRNA 7,153.0 118,067
4 MT-CO3 ENSG00000198938 protein_coding 6,892.7 57,214
5 S100A9 ENSG00000163220 protein_coding 6,476.5 39,291
6 TMSB4XP8 ENSG00000187653 processed_pseudogene 5,709.0 8,160
7 FTL ENSG00000087086 protein_coding 5,008.8 46,190
8 MT-ND1 ENSG00000198888 protein_coding 4,546.8 46,021
9 MT-ND4 ENSG00000198886 protein_coding 4,428.6 64,612
10 MT-RNR1 ENSG00000211459 Mt_rRNA 4,274.3 43,173

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,043.4
bar=donor   line=cohort median 		1,568.6 1,385.4 26.2%
2 S100A9 protein_coding 6,476.5
bar=donor   line=cohort median 		10,144.6 9,235.1 27.2%
3 IL1B protein_coding 3.3
bar=donor   line=cohort median 		6.9 6.1 19.9%
4 CXCL8 protein_coding 221.4
bar=donor   line=cohort median 		225.8 207.4 52.6%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 0.8
bar=donor   line=cohort median 		2.2 2.4 10.1%
6 FCGR3B protein_coding 130.0
bar=donor   line=cohort median 		157.0 129.3 51.0%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,243.3
bar=donor   line=cohort median 		802.6 706.2 85.2%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 58.7
bar=donor   line=cohort median 		56.8 56.4 53.6%
9 CD3E protein_coding 46.6
bar=donor   line=cohort median 		36.9 37.7 71.8%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.2
bar=donor   line=cohort median 		3.2 3.1 51.6%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 360.8
bar=donor   line=cohort median 		296.3 281.6 70.7%
12 GNLY protein_coding 86.5
bar=donor   line=cohort median 		77.5 70.7 61.9%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 125.4
bar=donor   line=cohort median 		509.6 582.1 5.4%
14 HBA1 protein_coding 708.8
bar=donor   line=cohort median 		1,931.5 1,960.7 16.8%
15 HBA2 protein_coding 470.5
bar=donor   line=cohort median 		1,068.0 1,083.5 20.5%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 8,336.5
bar=donor   line=cohort median 		7,011.1 6,938.4 72.3%
17 MT-CO2 protein_coding 7,458.8
bar=donor   line=cohort median 		5,968.9 5,810.8 74.4%
18 MT-ND1 protein_coding 4,546.8
bar=donor   line=cohort median 		3,670.4 3,718.2 73.3%
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