GSM6881274

Dataset: gse221521 • Sample: DM group RNA302 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

13,330,079 Total counts Group median: 12,709,871 • 74.9%ile (≈ Median)
25,445 Detected genes Group median: 2,638 • 17.9%ile (↓ Low)
4 Mitochondrial fraction (%) Group median: 6 • 12.2%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

40.2Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.17 4.9%
FOXO3 Insulin/IGF-1 Signaling 17.70
bar=donor   line=cohort median 		12.92 82.1%
CETP Lipid Metabolism 0.46
bar=donor   line=cohort median 		0.40 64.0%
SIRT6 Sirtuin Family 4.05
bar=donor   line=cohort median 		3.67 69.7%
SIRT1 Sirtuin Family 2.39
bar=donor   line=cohort median 		3.48 4.4%
SIRT3 Sirtuin Family 1.06
bar=donor   line=cohort median 		1.10 42.2%
IGF1R Insulin/IGF-1 Signaling 6.01
bar=donor   line=cohort median 		4.33 78.0%
KLOTHO Anti-aging 0.03
bar=donor   line=cohort median 		0.06 24.6%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.02
bar=donor   line=cohort median 		0.07 22.5%
TERT Telomere Maintenance 0.01
bar=donor   line=cohort median 		0.01 40.7%
IRS2 Insulin/IGF-1 Signaling 73.57
bar=donor   line=cohort median 		35.28 90.9%
TP53 Tumor Suppression 2.61
bar=donor   line=cohort median 		3.83 14.8%
SHC1 Signal Transduction 7.26
bar=donor   line=cohort median 		8.77 7.0%
ACE Signal Transduction 0.15
bar=donor   line=cohort median 		0.39 8.6%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 23,396.0 178,702
2 MT-RNR2 ENSG00000210082 Mt_rRNA 7,651.2 159,004
3 FTL ENSG00000087086 protein_coding 5,884.9 68,327
4 MT-CO2 ENSG00000198712 protein_coding 4,821.0 43,957
5 MT-CO1 ENSG00000198804 protein_coding 4,243.3 87,221
6 MT-RNR1 ENSG00000211459 Mt_rRNA 4,084.6 51,943
7 MT-CO3 ENSG00000198938 protein_coding 3,905.4 40,814
8 S100A8 ENSG00000143546 protein_coding 3,827.9 63,528
9 G0S2 ENSG00000123689 protein_coding 3,430.8 40,062
10 DUSP1 ENSG00000120129 protein_coding 3,259.4 87,461

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 3,827.9
bar=donor   line=cohort median 		1,568.6 1,385.4 98.7%
2 S100A9 protein_coding 23,396.0
bar=donor   line=cohort median 		10,144.6 9,235.1 97.7%
3 IL1B protein_coding 9.0
bar=donor   line=cohort median 		6.9 6.1 71.2%
4 CXCL8 protein_coding 813.7
bar=donor   line=cohort median 		225.8 207.4 96.6%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.6
bar=donor   line=cohort median 		2.2 2.4 32.9%
6 FCGR3B protein_coding 443.2
bar=donor   line=cohort median 		157.0 129.3 97.7%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 660.1
bar=donor   line=cohort median 		802.6 706.2 44.8%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 52.2
bar=donor   line=cohort median 		56.8 56.4 45.3%
9 CD3E protein_coding 30.7
bar=donor   line=cohort median 		36.9 37.7 27.7%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.6
bar=donor   line=cohort median 		3.2 3.1 34.5%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 341.0
bar=donor   line=cohort median 		296.3 281.6 66.1%
12 GNLY protein_coding 133.0
bar=donor   line=cohort median 		77.5 70.7 86.8%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 192.0
bar=donor   line=cohort median 		509.6 582.1 13.7%
14 HBA1 protein_coding 736.7
bar=donor   line=cohort median 		1,931.5 1,960.7 17.9%
15 HBA2 protein_coding 465.3
bar=donor   line=cohort median 		1,068.0 1,083.5 19.9%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 4,243.3
bar=donor   line=cohort median 		7,011.1 6,938.4 6.0%
17 MT-CO2 protein_coding 4,821.0
bar=donor   line=cohort median 		5,968.9 5,810.8 23.1%
18 MT-ND1 protein_coding 2,202.4
bar=donor   line=cohort median 		3,670.4 3,718.2 9.1%
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