GSM6881276

Dataset: gse221521 • Sample: DR group RNA303 • Status: Diabetic retinopathy
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Quality Control Metrics

13,289,457 Total counts Group median: 12,498,211 • 72.3%ile (≈ Median)
24,927 Detected genes Group median: 27,368 • 12.7%ile (↓ Low)
6 Mitochondrial fraction (%) Group median: 6 • 53.1%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

45.2Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.02
bar=donor   line=cohort median 		0.17 10.1%
FOXO3 Insulin/IGF-1 Signaling 10.80
bar=donor   line=cohort median 		12.92 28.2%
CETP Lipid Metabolism 0.36
bar=donor   line=cohort median 		0.40 39.6%
SIRT6 Sirtuin Family 5.42
bar=donor   line=cohort median 		3.67 97.2%
SIRT1 Sirtuin Family 2.50
bar=donor   line=cohort median 		3.48 8.0%
SIRT3 Sirtuin Family 1.33
bar=donor   line=cohort median 		1.10 83.7%
IGF1R Insulin/IGF-1 Signaling 5.06
bar=donor   line=cohort median 		4.33 63.5%
KLOTHO Anti-aging 0.00
bar=donor   line=cohort median 		0.06 5.2%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.26
bar=donor   line=cohort median 		0.07 94.0%
TERT Telomere Maintenance 0.02
bar=donor   line=cohort median 		0.01 66.6%
IRS2 Insulin/IGF-1 Signaling 25.24
bar=donor   line=cohort median 		35.28 29.3%
TP53 Tumor Suppression 2.34
bar=donor   line=cohort median 		3.83 6.5%
SHC1 Signal Transduction 8.00
bar=donor   line=cohort median 		8.77 21.5%
ACE Signal Transduction 0.54
bar=donor   line=cohort median 		0.39 75.9%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 17,078.7 130,052
2 MT-RNR2 ENSG00000210082 Mt_rRNA 9,002.3 186,511
3 MT-CO2 ENSG00000198712 protein_coding 8,427.1 76,602
4 HBA1 ENSG00000206172 protein_coding 7,180.9 164,140
5 MT-CO3 ENSG00000198938 protein_coding 6,946.9 72,379
6 MT-ND3 ENSG00000198840 protein_coding 6,083.1 27,971
7 MT-CO1 ENSG00000198804 protein_coding 5,611.2 114,987
8 HBA2 ENSG00000188536 protein_coding 5,488.4 123,119
9 MT-RNR1 ENSG00000211459 Mt_rRNA 4,868.6 61,725
10 FTL ENSG00000087086 protein_coding 4,760.1 55,099

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 2,014.3
bar=donor   line=cohort median 		1,223.7 1,385.4 76.9%
2 S100A9 protein_coding 17,078.7
bar=donor   line=cohort median 		7,732.1 9,235.1 90.4%
3 IL1B protein_coding 3.2
bar=donor   line=cohort median 		4.9 6.1 18.9%
4 CXCL8 protein_coding 434.9
bar=donor   line=cohort median 		197.4 207.4 85.8%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 4.8
bar=donor   line=cohort median 		2.9 2.4 80.6%
6 FCGR3B protein_coding 219.7
bar=donor   line=cohort median 		108.9 129.3 83.7%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 269.7
bar=donor   line=cohort median 		581.4 706.2 7.0%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 76.4
bar=donor   line=cohort median 		51.6 56.4 71.8%
9 CD3E protein_coding 50.1
bar=donor   line=cohort median 		38.1 37.7 76.4%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.3
bar=donor   line=cohort median 		3.0 3.1 26.7%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 379.8
bar=donor   line=cohort median 		252.2 281.6 74.9%
12 GNLY protein_coding 120.5
bar=donor   line=cohort median 		58.9 70.7 83.2%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 1,001.3
bar=donor   line=cohort median 		585.0 582.1 71.8%
14 HBA1 protein_coding 7,180.9
bar=donor   line=cohort median 		1,960.4 1,960.7 88.9%
15 HBA2 protein_coding 5,488.4
bar=donor   line=cohort median 		1,080.5 1,083.5 94.0%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 5,611.2
bar=donor   line=cohort median 		6,740.9 6,938.4 24.1%
17 MT-CO2 protein_coding 8,427.1
bar=donor   line=cohort median 		5,693.7 5,810.8 84.2%
18 MT-ND1 protein_coding 4,505.6
bar=donor   line=cohort median 		3,876.8 3,718.2 72.3%
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