GSM6881277

Dataset: gse221521 • Sample: DR group RNA31 • Status: Diabetic retinopathy
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Quality Control Metrics

12,024,768 Total counts Group median: 12,498,211 • 28.2%ile (≈ Median)
28,058 Detected genes Group median: 27,368 • 90.4%ile (↑ High)
6 Mitochondrial fraction (%) Group median: 6 • 43.3%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

45.2Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.17 4.9%
FOXO3 Insulin/IGF-1 Signaling 12.89
bar=donor   line=cohort median 		12.92 48.5%
CETP Lipid Metabolism 0.53
bar=donor   line=cohort median 		0.40 72.8%
SIRT6 Sirtuin Family 4.82
bar=donor   line=cohort median 		3.67 89.4%
SIRT1 Sirtuin Family 3.74
bar=donor   line=cohort median 		3.48 63.5%
SIRT3 Sirtuin Family 1.26
bar=donor   line=cohort median 		1.10 69.7%
IGF1R Insulin/IGF-1 Signaling 0.49
bar=donor   line=cohort median 		4.33 3.4%
KLOTHO Anti-aging 0.16
bar=donor   line=cohort median 		0.06 90.9%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.02
bar=donor   line=cohort median 		0.07 24.6%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 35.67
bar=donor   line=cohort median 		35.28 51.0%
TP53 Tumor Suppression 4.27
bar=donor   line=cohort median 		3.83 61.9%
SHC1 Signal Transduction 8.15
bar=donor   line=cohort median 		8.77 28.2%
ACE Signal Transduction 0.11
bar=donor   line=cohort median 		0.39 2.3%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 16,667.6 114,843
2 MT-RNR2 ENSG00000210082 Mt_rRNA 9,413.6 176,474
3 MT-CO1 ENSG00000198804 protein_coding 6,182.0 114,628
4 MT-CO2 ENSG00000198712 protein_coding 6,104.6 50,210
5 MT-RNR1 ENSG00000211459 Mt_rRNA 5,244.7 60,165
6 FTL ENSG00000087086 protein_coding 5,238.8 54,869
7 MT-CO3 ENSG00000198938 protein_coding 5,158.3 48,629
8 MT-ND3 ENSG00000198840 protein_coding 3,968.7 16,512
9 MT-ND1 ENSG00000198888 protein_coding 3,419.5 39,309
10 MT-ND2 ENSG00000198763 protein_coding 3,102.8 38,878

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 2,923.6
bar=donor   line=cohort median 		1,223.7 1,385.4 94.0%
2 S100A9 protein_coding 16,667.6
bar=donor   line=cohort median 		7,732.1 9,235.1 88.3%
3 IL1B protein_coding 9.3
bar=donor   line=cohort median 		4.9 6.1 74.4%
4 CXCL8 protein_coding 320.2
bar=donor   line=cohort median 		197.4 207.4 70.7%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 6.3
bar=donor   line=cohort median 		2.9 2.4 84.7%
6 FCGR3B protein_coding 179.1
bar=donor   line=cohort median 		108.9 129.3 69.2%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,834.8
bar=donor   line=cohort median 		581.4 706.2 97.2%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 40.4
bar=donor   line=cohort median 		51.6 56.4 24.1%
9 CD3E protein_coding 22.3
bar=donor   line=cohort median 		38.1 37.7 8.5%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 4.5
bar=donor   line=cohort median 		3.0 3.1 76.9%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 276.6
bar=donor   line=cohort median 		252.2 281.6 47.9%
12 GNLY protein_coding 99.6
bar=donor   line=cohort median 		58.9 70.7 70.2%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 200.0
bar=donor   line=cohort median 		585.0 582.1 14.2%
14 HBA1 protein_coding 501.1
bar=donor   line=cohort median 		1,960.4 1,960.7 6.5%
15 HBA2 protein_coding 282.1
bar=donor   line=cohort median 		1,080.5 1,083.5 7.0%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 6,182.0
bar=donor   line=cohort median 		6,740.9 6,938.4 32.9%
17 MT-CO2 protein_coding 6,104.6
bar=donor   line=cohort median 		5,693.7 5,810.8 56.7%
18 MT-ND1 protein_coding 3,419.5
bar=donor   line=cohort median 		3,876.8 3,718.2 38.1%
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