GSM6881278

Dataset: gse221521 • Sample: Control group RNA310 • Status: Healthy control
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Quality Control Metrics

13,017,880 Total counts Group median: 12,762,148 • 63.0%ile (≈ Median)
24,961 Detected genes Group median: 2,606 • 13.2%ile (↓ Low)
12 Mitochondrial fraction (%) Group median: 6 • 96.6%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

59.0Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.59
bar=donor   line=cohort median 		0.17 98.2%
FOXO3 Insulin/IGF-1 Signaling 5.42
bar=donor   line=cohort median 		12.92 4.4%
CETP Lipid Metabolism 0.53
bar=donor   line=cohort median 		0.40 71.8%
SIRT6 Sirtuin Family 4.40
bar=donor   line=cohort median 		3.67 80.6%
SIRT1 Sirtuin Family 2.33
bar=donor   line=cohort median 		3.48 2.3%
SIRT3 Sirtuin Family 1.46
bar=donor   line=cohort median 		1.10 92.0%
IGF1R Insulin/IGF-1 Signaling 2.22
bar=donor   line=cohort median 		4.33 21.5%
KLOTHO Anti-aging 0.08
bar=donor   line=cohort median 		0.06 58.3%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.09
bar=donor   line=cohort median 		0.07 63.5%
TERT Telomere Maintenance 0.07
bar=donor   line=cohort median 		0.01 95.1%
IRS2 Insulin/IGF-1 Signaling 7.30
bar=donor   line=cohort median 		35.28 2.9%
TP53 Tumor Suppression 6.19
bar=donor   line=cohort median 		3.83 94.0%
SHC1 Signal Transduction 9.63
bar=donor   line=cohort median 		8.77 79.5%
ACE Signal Transduction 0.52
bar=donor   line=cohort median 		0.39 72.8%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 20,508.4 416,215
2 MT-RNR1 ENSG00000211459 Mt_rRNA 13,111.7 162,835
3 MT-CO2 ENSG00000198712 protein_coding 12,806.5 114,032
4 MT-CO3 ENSG00000198938 protein_coding 12,080.9 123,298
5 MT-CO1 ENSG00000198804 protein_coding 10,433.0 209,428
6 MT-ND3 ENSG00000198840 protein_coding 10,179.0 45,848
7 MT-ND1 ENSG00000198888 protein_coding 9,475.8 117,927
8 MT-ND4 ENSG00000198886 protein_coding 6,148.1 110,288
9 MT-ND2 ENSG00000198763 protein_coding 5,807.5 78,777
10 RPS28P7 ENSG00000227097 processed_pseudogene 5,772.3 15,780

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 509.3
bar=donor   line=cohort median 		1,535.8 1,385.4 7.0%
2 S100A9 protein_coding 3,193.5
bar=donor   line=cohort median 		10,851.3 9,235.1 7.0%
3 IL1B protein_coding 1.7
bar=donor   line=cohort median 		5.6 6.1 8.5%
4 CXCL8 protein_coding 19.4
bar=donor   line=cohort median 		220.4 207.4 1.8%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.3
bar=donor   line=cohort median 		1.7 2.4 24.6%
6 FCGR3B protein_coding 26.9
bar=donor   line=cohort median 		145.0 129.3 6.0%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 221.2
bar=donor   line=cohort median 		709.1 706.2 5.4%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 128.9
bar=donor   line=cohort median 		66.1 56.4 95.6%
9 CD3E protein_coding 80.2
bar=donor   line=cohort median 		37.6 37.7 95.6%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.9
bar=donor   line=cohort median 		3.1 3.1 67.1%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 754.6
bar=donor   line=cohort median 		302.3 281.6 97.7%
12 GNLY protein_coding 257.2
bar=donor   line=cohort median 		80.1 70.7 99.2%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 946.4
bar=donor   line=cohort median 		598.7 582.1 69.7%
14 HBA1 protein_coding 4,033.7
bar=donor   line=cohort median 		2,133.6 1,960.7 74.4%
15 HBA2 protein_coding 2,680.4
bar=donor   line=cohort median 		1,142.2 1,083.5 79.5%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 10,433.0
bar=donor   line=cohort median 		6,862.1 6,938.4 93.5%
17 MT-CO2 protein_coding 12,806.5
bar=donor   line=cohort median 		6,023.6 5,810.8 98.2%
18 MT-ND1 protein_coding 9,475.8
bar=donor   line=cohort median 		3,656.3 3,718.2 98.2%
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