GSM6881279

Dataset: gse221521 • Sample: DR group RNA314 • Status: Diabetic retinopathy
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Quality Control Metrics

10,573,520 Total counts Group median: 12,498,211 • 7.0%ile (↓ Low)
25,462 Detected genes Group median: 27,368 • 18.4%ile (↓ Low)
9 Mitochondrial fraction (%) Group median: 6 • 88.3%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

58.1Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.33
bar=donor   line=cohort median 		0.17 86.8%
FOXO3 Insulin/IGF-1 Signaling 10.82
bar=donor   line=cohort median 		12.92 28.8%
CETP Lipid Metabolism 0.36
bar=donor   line=cohort median 		0.40 40.2%
SIRT6 Sirtuin Family 4.23
bar=donor   line=cohort median 		3.67 75.9%
SIRT1 Sirtuin Family 3.04
bar=donor   line=cohort median 		3.48 28.2%
SIRT3 Sirtuin Family 1.68
bar=donor   line=cohort median 		1.10 98.2%
IGF1R Insulin/IGF-1 Signaling 3.68
bar=donor   line=cohort median 		4.33 42.8%
KLOTHO Anti-aging 0.10
bar=donor   line=cohort median 		0.06 71.2%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.09
bar=donor   line=cohort median 		0.07 65.5%
TERT Telomere Maintenance 0.03
bar=donor   line=cohort median 		0.01 78.0%
IRS2 Insulin/IGF-1 Signaling 28.32
bar=donor   line=cohort median 		35.28 38.1%
TP53 Tumor Suppression 4.63
bar=donor   line=cohort median 		3.83 70.7%
SHC1 Signal Transduction 8.56
bar=donor   line=cohort median 		8.77 42.8%
ACE Signal Transduction 0.42
bar=donor   line=cohort median 		0.39 55.2%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 13,058.9 215,264
2 MT-CO3 ENSG00000198938 protein_coding 9,945.8 82,447
3 MT-CO2 ENSG00000198712 protein_coding 9,917.9 71,729
4 MT-CO1 ENSG00000198804 protein_coding 9,488.2 154,699
5 MT-RNR1 ENSG00000211459 Mt_rRNA 9,392.7 94,745
6 S100A9 ENSG00000163220 protein_coding 7,147.2 43,302
7 MT-ND3 ENSG00000198840 protein_coding 6,731.3 24,626
8 MT-ND1 ENSG00000198888 protein_coding 6,066.8 61,325
9 FTL ENSG00000087086 protein_coding 5,166.6 47,582
10 MT-ND4 ENSG00000198886 protein_coding 4,942.9 72,019

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,018.6
bar=donor   line=cohort median 		1,223.7 1,385.4 23.1%
2 S100A9 protein_coding 7,147.2
bar=donor   line=cohort median 		7,732.1 9,235.1 32.4%
3 IL1B protein_coding 3.0
bar=donor   line=cohort median 		4.9 6.1 16.8%
4 CXCL8 protein_coding 318.9
bar=donor   line=cohort median 		197.4 207.4 69.2%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.5
bar=donor   line=cohort median 		2.9 2.4 30.8%
6 FCGR3B protein_coding 107.0
bar=donor   line=cohort median 		108.9 129.3 37.6%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 839.5
bar=donor   line=cohort median 		581.4 706.2 61.9%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 100.6
bar=donor   line=cohort median 		51.6 56.4 88.3%
9 CD3E protein_coding 77.0
bar=donor   line=cohort median 		38.1 37.7 94.0%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.5
bar=donor   line=cohort median 		3.0 3.1 61.9%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 527.8
bar=donor   line=cohort median 		252.2 281.6 89.9%
12 GNLY protein_coding 116.7
bar=donor   line=cohort median 		58.9 70.7 81.1%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 1,139.7
bar=donor   line=cohort median 		585.0 582.1 74.9%
14 HBA1 protein_coding 4,941.6
bar=donor   line=cohort median 		1,960.4 1,960.7 78.0%
15 HBA2 protein_coding 3,059.9
bar=donor   line=cohort median 		1,080.5 1,083.5 81.6%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 9,488.2
bar=donor   line=cohort median 		6,740.9 6,938.4 89.4%
17 MT-CO2 protein_coding 9,917.9
bar=donor   line=cohort median 		5,693.7 5,810.8 92.0%
18 MT-ND1 protein_coding 6,066.8
bar=donor   line=cohort median 		3,876.8 3,718.2 88.3%
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