GSM6881280

Dataset: gse221521 • Sample: Control group RNA315 • Status: Healthy control
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Quality Control Metrics

9,813,698 Total counts Group median: 12,762,148 • 2.8%ile (↓ Low)
24,718 Detected genes Group median: 2,606 • 10.1%ile (↓ Low)
7 Mitochondrial fraction (%) Group median: 6 • 71.2%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

54.9Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.16
bar=donor   line=cohort median 		0.17 49.5%
FOXO3 Insulin/IGF-1 Signaling 8.18
bar=donor   line=cohort median 		12.92 14.3%
CETP Lipid Metabolism 0.55
bar=donor   line=cohort median 		0.40 76.4%
SIRT6 Sirtuin Family 2.09
bar=donor   line=cohort median 		3.67 3.4%
SIRT1 Sirtuin Family 5.12
bar=donor   line=cohort median 		3.48 90.9%
SIRT3 Sirtuin Family 1.28
bar=donor   line=cohort median 		1.10 73.8%
IGF1R Insulin/IGF-1 Signaling 2.96
bar=donor   line=cohort median 		4.33 32.4%
KLOTHO Anti-aging 0.02
bar=donor   line=cohort median 		0.06 18.4%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.14
bar=donor   line=cohort median 		0.07 82.1%
TERT Telomere Maintenance 0.03
bar=donor   line=cohort median 		0.01 79.0%
IRS2 Insulin/IGF-1 Signaling 7.93
bar=donor   line=cohort median 		35.28 4.9%
TP53 Tumor Suppression 6.14
bar=donor   line=cohort median 		3.83 93.5%
SHC1 Signal Transduction 9.07
bar=donor   line=cohort median 		8.77 60.9%
ACE Signal Transduction 0.99
bar=donor   line=cohort median 		0.39 96.1%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-CO1 ENSG00000198804 protein_coding 12,118.3 183,383
2 MT-RNR2 ENSG00000210082 Mt_rRNA 10,904.6 166,836
3 RPS28P7 ENSG00000227097 processed_pseudogene 6,990.7 14,407
4 HBA1 ENSG00000206172 protein_coding 5,666.6 95,650
5 MT-CO3 ENSG00000198938 protein_coding 5,402.3 41,565
6 MT-CO2 ENSG00000198712 protein_coding 5,316.4 35,687
7 EEF1A1P5 ENSG00000196205 processed_pseudogene 5,084.0 69,301
8 RPL13AP5 ENSG00000236552 processed_pseudogene 5,022.2 30,163
9 TMSB4XP8 ENSG00000187653 processed_pseudogene 4,533.3 6,006
10 MT-ND4 ENSG00000198886 protein_coding 4,309.9 58,284

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 97.4
bar=donor   line=cohort median 		1,535.8 1,385.4 0.3%
2 S100A9 protein_coding 387.9
bar=donor   line=cohort median 		10,851.3 9,235.1 0.8%
3 IL1B protein_coding 0.8
bar=donor   line=cohort median 		5.6 6.1 4.4%
4 CXCL8 protein_coding 9.4
bar=donor   line=cohort median 		220.4 207.4 0.8%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 0.2
bar=donor   line=cohort median 		1.7 2.4 1.8%
6 FCGR3B protein_coding 2.0
bar=donor   line=cohort median 		145.0 129.3 0.3%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 290.4
bar=donor   line=cohort median 		709.1 706.2 11.1%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 127.0
bar=donor   line=cohort median 		66.1 56.4 95.1%
9 CD3E protein_coding 79.0
bar=donor   line=cohort median 		37.6 37.7 95.1%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 5.0
bar=donor   line=cohort median 		3.1 3.1 81.6%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 329.6
bar=donor   line=cohort median 		302.3 281.6 64.5%
12 GNLY protein_coding 105.9
bar=donor   line=cohort median 		80.1 70.7 74.4%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 950.3
bar=donor   line=cohort median 		598.7 582.1 70.2%
14 HBA1 protein_coding 5,666.6
bar=donor   line=cohort median 		2,133.6 1,960.7 82.1%
15 HBA2 protein_coding 1,237.9
bar=donor   line=cohort median 		1,142.2 1,083.5 59.3%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 12,118.3
bar=donor   line=cohort median 		6,862.1 6,938.4 96.1%
17 MT-CO2 protein_coding 5,316.4
bar=donor   line=cohort median 		6,023.6 5,810.8 35.5%
18 MT-ND1 protein_coding 3,594.7
bar=donor   line=cohort median 		3,656.3 3,718.2 43.8%
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