GSM6881283

Dataset: gse221521 • Sample: DM group RNA319 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

13,022,363 Total counts Group median: 12,709,871 • 63.5%ile (≈ Median)
25,881 Detected genes Group median: 2,638 • 30.3%ile (≈ Median)
9 Mitochondrial fraction (%) Group median: 6 • 87.3%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

49.2Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.31
bar=donor   line=cohort median 		0.17 83.2%
FOXO3 Insulin/IGF-1 Signaling 7.33
bar=donor   line=cohort median 		12.92 10.6%
CETP Lipid Metabolism 0.56
bar=donor   line=cohort median 		0.40 78.0%
SIRT6 Sirtuin Family 4.15
bar=donor   line=cohort median 		3.67 74.4%
SIRT1 Sirtuin Family 2.91
bar=donor   line=cohort median 		3.48 23.6%
SIRT3 Sirtuin Family 1.33
bar=donor   line=cohort median 		1.10 84.7%
IGF1R Insulin/IGF-1 Signaling 0.57
bar=donor   line=cohort median 		4.33 6.0%
KLOTHO Anti-aging 0.01
bar=donor   line=cohort median 		0.06 13.2%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.12
bar=donor   line=cohort median 		0.07 79.5%
TERT Telomere Maintenance 0.01
bar=donor   line=cohort median 		0.01 42.2%
IRS2 Insulin/IGF-1 Signaling 34.15
bar=donor   line=cohort median 		35.28 49.0%
TP53 Tumor Suppression 3.56
bar=donor   line=cohort median 		3.83 40.2%
SHC1 Signal Transduction 7.99
bar=donor   line=cohort median 		8.77 21.0%
ACE Signal Transduction 0.63
bar=donor   line=cohort median 		0.39 84.7%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-CO2 ENSG00000198712 protein_coding 11,595.9 103,288
2 MT-CO3 ENSG00000198938 protein_coding 11,474.1 117,145
3 MT-RNR2 ENSG00000210082 Mt_rRNA 10,883.1 220,947
4 S100A9 ENSG00000163220 protein_coding 10,122.3 75,531
5 MT-CO1 ENSG00000198804 protein_coding 9,714.0 195,061
6 MT-RNR1 ENSG00000211459 Mt_rRNA 7,439.7 92,426
7 MT-ND1 ENSG00000198888 protein_coding 6,763.6 84,202
8 FTL ENSG00000087086 protein_coding 6,091.2 69,089
9 MT-ND3 ENSG00000198840 protein_coding 5,820.4 26,225
10 RPS28P7 ENSG00000227097 processed_pseudogene 5,412.7 14,802

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,710.1
bar=donor   line=cohort median 		1,568.6 1,385.4 63.0%
2 S100A9 protein_coding 10,122.3
bar=donor   line=cohort median 		10,144.6 9,235.1 57.8%
3 IL1B protein_coding 4.5
bar=donor   line=cohort median 		6.9 6.1 33.4%
4 CXCL8 protein_coding 183.3
bar=donor   line=cohort median 		225.8 207.4 41.7%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 3.5
bar=donor   line=cohort median 		2.2 2.4 72.3%
6 FCGR3B protein_coding 67.9
bar=donor   line=cohort median 		157.0 129.3 15.3%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,561.3
bar=donor   line=cohort median 		802.6 706.2 91.5%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 95.3
bar=donor   line=cohort median 		56.8 56.4 86.3%
9 CD3E protein_coding 69.3
bar=donor   line=cohort median 		36.9 37.7 89.9%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.0
bar=donor   line=cohort median 		3.2 3.1 46.4%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 486.3
bar=donor   line=cohort median 		296.3 281.6 86.8%
12 GNLY protein_coding 182.8
bar=donor   line=cohort median 		77.5 70.7 96.1%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 791.7
bar=donor   line=cohort median 		509.6 582.1 63.5%
14 HBA1 protein_coding 5,264.0
bar=donor   line=cohort median 		1,931.5 1,960.7 80.1%
15 HBA2 protein_coding 3,020.3
bar=donor   line=cohort median 		1,068.0 1,083.5 81.1%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 9,714.0
bar=donor   line=cohort median 		7,011.1 6,938.4 90.4%
17 MT-CO2 protein_coding 11,595.9
bar=donor   line=cohort median 		5,968.9 5,810.8 96.1%
18 MT-ND1 protein_coding 6,763.6
bar=donor   line=cohort median 		3,670.4 3,718.2 94.0%
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