GSM6881284

Dataset: gse221521 • Sample: DR group RNA32 • Status: Diabetic retinopathy
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Quality Control Metrics

10,056,143 Total counts Group median: 12,498,211 • 3.9%ile (↓ Low)
25,765 Detected genes Group median: 27,368 • 25.6%ile (≈ Median)
4 Mitochondrial fraction (%) Group median: 6 • 9.6%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

44.4Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.11
bar=donor   line=cohort median 		0.17 33.4%
FOXO3 Insulin/IGF-1 Signaling 18.95
bar=donor   line=cohort median 		12.92 91.5%
CETP Lipid Metabolism 0.14
bar=donor   line=cohort median 		0.40 2.9%
SIRT6 Sirtuin Family 2.67
bar=donor   line=cohort median 		3.67 9.6%
SIRT1 Sirtuin Family 3.52
bar=donor   line=cohort median 		3.48 54.2%
SIRT3 Sirtuin Family 0.65
bar=donor   line=cohort median 		1.10 3.4%
IGF1R Insulin/IGF-1 Signaling 2.90
bar=donor   line=cohort median 		4.33 31.9%
KLOTHO Anti-aging 0.14
bar=donor   line=cohort median 		0.06 84.2%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.10
bar=donor   line=cohort median 		0.07 70.7%
TERT Telomere Maintenance 0.02
bar=donor   line=cohort median 		0.01 62.4%
IRS2 Insulin/IGF-1 Signaling 49.15
bar=donor   line=cohort median 		35.28 70.7%
TP53 Tumor Suppression 3.11
bar=donor   line=cohort median 		3.83 24.1%
SHC1 Signal Transduction 6.82
bar=donor   line=cohort median 		8.77 5.4%
ACE Signal Transduction 0.52
bar=donor   line=cohort median 		0.39 73.3%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 10,761.7 62,011
2 MT-RNR2 ENSG00000210082 Mt_rRNA 5,669.5 88,884
3 MT-CO1 ENSG00000198804 protein_coding 4,963.4 76,965
4 TMSB4XP8 ENSG00000187653 processed_pseudogene 4,807.1 6,526
5 FTL ENSG00000087086 protein_coding 4,588.0 40,186
6 MT-CO2 ENSG00000198712 protein_coding 3,753.3 25,817
7 MT-CO3 ENSG00000198938 protein_coding 3,075.6 24,248
8 MT-ND1 ENSG00000198888 protein_coding 3,012.0 28,956
9 H3P6 ENSG00000235655 processed_pseudogene 2,798.6 11,567
10 MT-RNR1 ENSG00000211459 Mt_rRNA 2,754.5 26,425

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,733.3
bar=donor   line=cohort median 		1,223.7 1,385.4 65.0%
2 S100A9 protein_coding 10,761.7
bar=donor   line=cohort median 		7,732.1 9,235.1 60.9%
3 IL1B protein_coding 20.0
bar=donor   line=cohort median 		4.9 6.1 95.1%
4 CXCL8 protein_coding 427.2
bar=donor   line=cohort median 		197.4 207.4 84.2%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.9
bar=donor   line=cohort median 		2.9 2.4 40.7%
6 FCGR3B protein_coding 223.3
bar=donor   line=cohort median 		108.9 129.3 84.7%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 664.8
bar=donor   line=cohort median 		581.4 706.2 45.9%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 14.1
bar=donor   line=cohort median 		51.6 56.4 0.3%
9 CD3E protein_coding 12.8
bar=donor   line=cohort median 		38.1 37.7 1.3%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 4.9
bar=donor   line=cohort median 		3.0 3.1 81.1%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 84.9
bar=donor   line=cohort median 		252.2 281.6 2.3%
12 GNLY protein_coding 30.3
bar=donor   line=cohort median 		58.9 70.7 8.5%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 112.3
bar=donor   line=cohort median 		585.0 582.1 3.9%
14 HBA1 protein_coding 545.3
bar=donor   line=cohort median 		1,960.4 1,960.7 8.5%
15 HBA2 protein_coding 166.4
bar=donor   line=cohort median 		1,080.5 1,083.5 2.8%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 4,963.4
bar=donor   line=cohort median 		6,740.9 6,938.4 12.7%
17 MT-CO2 protein_coding 3,753.3
bar=donor   line=cohort median 		5,693.7 5,810.8 8.5%
18 MT-ND1 protein_coding 3,012.0
bar=donor   line=cohort median 		3,876.8 3,718.2 25.6%
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