GSM6881285

Dataset: gse221521 • Sample: Control group RNA325 • Status: Healthy control
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Quality Control Metrics

12,091,827 Total counts Group median: 12,762,148 • 30.8%ile (≈ Median)
23,425 Detected genes Group median: 2,606 • 4.4%ile (↓ Low)
7 Mitochondrial fraction (%) Group median: 6 • 68.7%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

38.1Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.42
bar=donor   line=cohort median 		0.17 96.1%
FOXO3 Insulin/IGF-1 Signaling 10.13
bar=donor   line=cohort median 		12.92 22.5%
CETP Lipid Metabolism 0.33
bar=donor   line=cohort median 		0.40 34.5%
SIRT6 Sirtuin Family 5.78
bar=donor   line=cohort median 		3.67 98.7%
SIRT1 Sirtuin Family 1.98
bar=donor   line=cohort median 		3.48 1.8%
SIRT3 Sirtuin Family 1.01
bar=donor   line=cohort median 		1.10 32.9%
IGF1R Insulin/IGF-1 Signaling 0.48
bar=donor   line=cohort median 		4.33 2.9%
KLOTHO Anti-aging 0.00
bar=donor   line=cohort median 		0.06 5.2%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.05
bar=donor   line=cohort median 		0.07 41.7%
TERT Telomere Maintenance 0.04
bar=donor   line=cohort median 		0.01 86.3%
IRS2 Insulin/IGF-1 Signaling 27.66
bar=donor   line=cohort median 		35.28 36.0%
TP53 Tumor Suppression 2.49
bar=donor   line=cohort median 		3.83 10.1%
SHC1 Signal Transduction 7.81
bar=donor   line=cohort median 		8.77 15.8%
ACE Signal Transduction 0.32
bar=donor   line=cohort median 		0.39 38.6%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 20,071.8 139,070
2 MT-RNR2 ENSG00000210082 Mt_rRNA 11,926.5 224,829
3 MT-CO2 ENSG00000198712 protein_coding 10,446.4 86,400
4 MT-CO3 ENSG00000198938 protein_coding 9,336.5 88,510
5 FTL ENSG00000087086 protein_coding 8,667.7 91,288
6 MT-RNR1 ENSG00000211459 Mt_rRNA 7,506.8 86,595
7 MT-ND3 ENSG00000198840 protein_coding 6,484.3 27,129
8 MT-CO1 ENSG00000198804 protein_coding 5,482.1 102,217
9 HBA1 ENSG00000206172 protein_coding 5,415.3 112,627
10 RPS28P7 ENSG00000227097 processed_pseudogene 5,302.7 13,465

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 2,647.3
bar=donor   line=cohort median 		1,535.8 1,385.4 90.9%
2 S100A9 protein_coding 20,071.8
bar=donor   line=cohort median 		10,851.3 9,235.1 93.5%
3 IL1B protein_coding 8.1
bar=donor   line=cohort median 		5.6 6.1 67.1%
4 CXCL8 protein_coding 699.9
bar=donor   line=cohort median 		220.4 207.4 95.1%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 0.8
bar=donor   line=cohort median 		1.7 2.4 9.6%
6 FCGR3B protein_coding 201.5
bar=donor   line=cohort median 		145.0 129.3 76.4%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 280.7
bar=donor   line=cohort median 		709.1 706.2 8.5%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 113.7
bar=donor   line=cohort median 		66.1 56.4 91.5%
9 CD3E protein_coding 80.6
bar=donor   line=cohort median 		37.6 37.7 96.1%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 1.1
bar=donor   line=cohort median 		3.1 3.1 3.9%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 417.4
bar=donor   line=cohort median 		302.3 281.6 79.5%
12 GNLY protein_coding 161.4
bar=donor   line=cohort median 		80.1 70.7 91.5%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 1,165.7
bar=donor   line=cohort median 		598.7 582.1 75.9%
14 HBA1 protein_coding 5,415.3
bar=donor   line=cohort median 		2,133.6 1,960.7 81.6%
15 HBA2 protein_coding 3,336.3
bar=donor   line=cohort median 		1,142.2 1,083.5 84.2%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 5,482.1
bar=donor   line=cohort median 		6,862.1 6,938.4 21.0%
17 MT-CO2 protein_coding 10,446.4
bar=donor   line=cohort median 		6,023.6 5,810.8 94.0%
18 MT-ND1 protein_coding 4,215.5
bar=donor   line=cohort median 		3,656.3 3,718.2 65.5%
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