GSM6881286

Dataset: gse221521 • Sample: DM group RNA328 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

12,567,869 Total counts Group median: 12,709,871 • 49.0%ile (≈ Median)
26,717 Detected genes Group median: 2,638 • 58.8%ile (≈ Median)
7 Mitochondrial fraction (%) Group median: 6 • 64.5%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

47.9Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.32
bar=donor   line=cohort median 		0.17 85.2%
FOXO3 Insulin/IGF-1 Signaling 17.36
bar=donor   line=cohort median 		12.92 80.6%
CETP Lipid Metabolism 0.53
bar=donor   line=cohort median 		0.40 72.3%
SIRT6 Sirtuin Family 3.18
bar=donor   line=cohort median 		3.67 23.6%
SIRT1 Sirtuin Family 3.56
bar=donor   line=cohort median 		3.48 56.7%
SIRT3 Sirtuin Family 1.10
bar=donor   line=cohort median 		1.10 50.5%
IGF1R Insulin/IGF-1 Signaling 3.82
bar=donor   line=cohort median 		4.33 44.8%
KLOTHO Anti-aging 0.00
bar=donor   line=cohort median 		0.06 5.2%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.13
bar=donor   line=cohort median 		0.07 81.6%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 49.37
bar=donor   line=cohort median 		35.28 71.2%
TP53 Tumor Suppression 3.09
bar=donor   line=cohort median 		3.83 23.1%
SHC1 Signal Transduction 8.41
bar=donor   line=cohort median 		8.77 37.1%
ACE Signal Transduction 0.23
bar=donor   line=cohort median 		0.39 20.0%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 8,792.8 172,280
2 S100A9 ENSG00000163220 protein_coding 8,697.5 62,634
3 MT-CO1 ENSG00000198804 protein_coding 7,932.2 153,724
4 MT-CO2 ENSG00000198712 protein_coding 7,346.4 63,153
5 MT-CO3 ENSG00000198938 protein_coding 7,057.3 69,537
6 MT-RNR1 ENSG00000211459 Mt_rRNA 4,911.2 58,884
7 HBA1 ENSG00000206172 protein_coding 4,775.0 103,219
8 FTL ENSG00000087086 protein_coding 4,641.4 50,808
9 MT-ND4 ENSG00000198886 protein_coding 4,338.9 75,144
10 MT-ND1 ENSG00000198888 protein_coding 4,198.8 50,448

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,312.2
bar=donor   line=cohort median 		1,568.6 1,385.4 44.3%
2 S100A9 protein_coding 8,697.5
bar=donor   line=cohort median 		10,144.6 9,235.1 46.9%
3 IL1B protein_coding 7.4
bar=donor   line=cohort median 		6.9 6.1 63.5%
4 CXCL8 protein_coding 424.0
bar=donor   line=cohort median 		225.8 207.4 83.7%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.4
bar=donor   line=cohort median 		2.2 2.4 28.8%
6 FCGR3B protein_coding 67.9
bar=donor   line=cohort median 		157.0 129.3 15.8%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 284.4
bar=donor   line=cohort median 		802.6 706.2 10.1%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 80.0
bar=donor   line=cohort median 		56.8 56.4 76.4%
9 CD3E protein_coding 59.5
bar=donor   line=cohort median 		36.9 37.7 87.3%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.3
bar=donor   line=cohort median 		3.2 3.1 54.7%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 371.5
bar=donor   line=cohort median 		296.3 281.6 72.8%
12 GNLY protein_coding 85.1
bar=donor   line=cohort median 		77.5 70.7 61.4%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 1,068.5
bar=donor   line=cohort median 		509.6 582.1 73.3%
14 HBA1 protein_coding 4,775.0
bar=donor   line=cohort median 		1,931.5 1,960.7 77.5%
15 HBA2 protein_coding 2,100.0
bar=donor   line=cohort median 		1,068.0 1,083.5 73.3%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 7,932.2
bar=donor   line=cohort median 		7,011.1 6,938.4 65.5%
17 MT-CO2 protein_coding 7,346.4
bar=donor   line=cohort median 		5,968.9 5,810.8 72.8%
18 MT-ND1 protein_coding 4,198.8
bar=donor   line=cohort median 		3,670.4 3,718.2 64.5%
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