GSM6881287

Dataset: gse221521 • Sample: Control group RNA330 • Status: Healthy control
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Quality Control Metrics

14,652,694 Total counts Group median: 12,762,148 • 89.9%ile (↑ High)
26,048 Detected genes Group median: 2,606 • 35.0%ile (≈ Median)
10 Mitochondrial fraction (%) Group median: 6 • 93.0%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

46.2Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.17 4.9%
FOXO3 Insulin/IGF-1 Signaling 8.86
bar=donor   line=cohort median 		12.92 15.8%
CETP Lipid Metabolism 0.32
bar=donor   line=cohort median 		0.40 32.9%
SIRT6 Sirtuin Family 2.85
bar=donor   line=cohort median 		3.67 12.7%
SIRT1 Sirtuin Family 3.61
bar=donor   line=cohort median 		3.48 59.3%
SIRT3 Sirtuin Family 1.26
bar=donor   line=cohort median 		1.10 72.8%
IGF1R Insulin/IGF-1 Signaling 0.46
bar=donor   line=cohort median 		4.33 1.8%
KLOTHO Anti-aging 0.05
bar=donor   line=cohort median 		0.06 39.6%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.25
bar=donor   line=cohort median 		0.07 93.5%
TERT Telomere Maintenance 0.03
bar=donor   line=cohort median 		0.01 76.9%
IRS2 Insulin/IGF-1 Signaling 13.18
bar=donor   line=cohort median 		35.28 8.0%
TP53 Tumor Suppression 4.83
bar=donor   line=cohort median 		3.83 74.4%
SHC1 Signal Transduction 9.58
bar=donor   line=cohort median 		8.77 77.5%
ACE Signal Transduction 0.53
bar=donor   line=cohort median 		0.39 74.4%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-CO1 ENSG00000198804 protein_coding 12,679.5 286,486
2 MT-CO2 ENSG00000198712 protein_coding 12,260.1 122,876
3 MT-ATP6 ENSG00000198899 protein_coding 10,368.1 103,458
4 MT-RNR2 ENSG00000210082 Mt_rRNA 9,841.1 224,806
5 MT-CO3 ENSG00000198938 protein_coding 8,630.3 99,142
6 MT-ND4 ENSG00000198886 protein_coding 7,645.8 154,379
7 HBA1 ENSG00000206172 protein_coding 7,542.9 190,100
8 MT-ND1 ENSG00000198888 protein_coding 7,031.9 98,502
9 RPL13AP5 ENSG00000236552 processed_pseudogene 5,452.3 48,893
10 RPS28P7 ENSG00000227097 processed_pseudogene 4,818.9 14,828

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 566.3
bar=donor   line=cohort median 		1,535.8 1,385.4 8.5%
2 S100A9 protein_coding 3,493.3
bar=donor   line=cohort median 		10,851.3 9,235.1 10.1%
3 IL1B protein_coding 1.9
bar=donor   line=cohort median 		5.6 6.1 9.1%
4 CXCL8 protein_coding 201.7
bar=donor   line=cohort median 		220.4 207.4 48.4%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.7
bar=donor   line=cohort median 		1.7 2.4 33.4%
6 FCGR3B protein_coding 55.3
bar=donor   line=cohort median 		145.0 129.3 12.2%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 409.5
bar=donor   line=cohort median 		709.1 706.2 18.4%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 124.9
bar=donor   line=cohort median 		66.1 56.4 94.0%
9 CD3E protein_coding 130.1
bar=donor   line=cohort median 		37.6 37.7 99.7%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.0
bar=donor   line=cohort median 		3.1 3.1 44.8%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 411.7
bar=donor   line=cohort median 		302.3 281.6 78.0%
12 GNLY protein_coding 179.4
bar=donor   line=cohort median 		80.1 70.7 95.6%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 1,162.2
bar=donor   line=cohort median 		598.7 582.1 75.4%
14 HBA1 protein_coding 7,542.9
bar=donor   line=cohort median 		2,133.6 1,960.7 89.9%
15 HBA2 protein_coding 2,506.0
bar=donor   line=cohort median 		1,142.2 1,083.5 77.5%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 12,679.5
bar=donor   line=cohort median 		6,862.1 6,938.4 97.2%
17 MT-CO2 protein_coding 12,260.1
bar=donor   line=cohort median 		6,023.6 5,810.8 97.7%
18 MT-ND1 protein_coding 7,031.9
bar=donor   line=cohort median 		3,656.3 3,718.2 94.6%
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