GSM6881289

Dataset: gse221521 • Sample: DM group RNA331 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

14,329,768 Total counts Group median: 12,709,871 • 86.3%ile (↑ High)
27,327 Detected genes Group median: 2,638 • 73.3%ile (≈ Median)
8 Mitochondrial fraction (%) Group median: 6 • 84.7%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

52.6Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.19
bar=donor   line=cohort median 		0.17 56.7%
FOXO3 Insulin/IGF-1 Signaling 7.35
bar=donor   line=cohort median 		12.92 11.1%
CETP Lipid Metabolism 0.58
bar=donor   line=cohort median 		0.40 80.6%
SIRT6 Sirtuin Family 3.31
bar=donor   line=cohort median 		3.67 28.8%
SIRT1 Sirtuin Family 3.35
bar=donor   line=cohort median 		3.48 40.7%
SIRT3 Sirtuin Family 1.23
bar=donor   line=cohort median 		1.10 65.5%
IGF1R Insulin/IGF-1 Signaling 3.41
bar=donor   line=cohort median 		4.33 38.1%
KLOTHO Anti-aging 0.00
bar=donor   line=cohort median 		0.06 5.2%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.29
bar=donor   line=cohort median 		0.07 96.1%
TERT Telomere Maintenance 0.03
bar=donor   line=cohort median 		0.01 77.5%
IRS2 Insulin/IGF-1 Signaling 15.25
bar=donor   line=cohort median 		35.28 9.1%
TP53 Tumor Suppression 4.46
bar=donor   line=cohort median 		3.83 66.1%
SHC1 Signal Transduction 9.54
bar=donor   line=cohort median 		8.77 76.4%
ACE Signal Transduction 0.72
bar=donor   line=cohort median 		0.39 88.9%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 HBA1 ENSG00000206172 protein_coding 17,332.6 427,201
2 MT-RNR2 ENSG00000210082 Mt_rRNA 13,409.5 299,569
3 MT-CO2 ENSG00000198712 protein_coding 9,508.9 93,202
4 HBA2 ENSG00000188536 protein_coding 9,227.4 223,199
5 MT-RNR1 ENSG00000211459 Mt_rRNA 8,845.3 120,921
6 MT-CO3 ENSG00000198938 protein_coding 7,899.8 88,751
7 MT-CO1 ENSG00000198804 protein_coding 7,420.7 163,972
8 AC005912.1 ENSG00000227081 processed_pseudogene 6,322.0 23,101
9 MT-ND1 ENSG00000198888 protein_coding 5,627.0 77,086
10 RPS28P7 ENSG00000227097 processed_pseudogene 5,478.4 16,486

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 623.7
bar=donor   line=cohort median 		1,568.6 1,385.4 9.6%
2 S100A9 protein_coding 3,202.4
bar=donor   line=cohort median 		10,144.6 9,235.1 7.5%
3 IL1B protein_coding 2.6
bar=donor   line=cohort median 		6.9 6.1 13.2%
4 CXCL8 protein_coding 45.1
bar=donor   line=cohort median 		225.8 207.4 7.5%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 0.5
bar=donor   line=cohort median 		2.2 2.4 6.5%
6 FCGR3B protein_coding 26.4
bar=donor   line=cohort median 		157.0 129.3 5.4%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 268.6
bar=donor   line=cohort median 		802.6 706.2 6.5%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 104.1
bar=donor   line=cohort median 		56.8 56.4 88.9%
9 CD3E protein_coding 64.4
bar=donor   line=cohort median 		36.9 37.7 88.3%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 1.8
bar=donor   line=cohort median 		3.2 3.1 13.7%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 731.0
bar=donor   line=cohort median 		296.3 281.6 97.2%
12 GNLY protein_coding 177.9
bar=donor   line=cohort median 		77.5 70.7 95.1%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 4,461.5
bar=donor   line=cohort median 		509.6 582.1 97.7%
14 HBA1 protein_coding 17,332.6
bar=donor   line=cohort median 		1,931.5 1,960.7 99.2%
15 HBA2 protein_coding 9,227.4
bar=donor   line=cohort median 		1,068.0 1,083.5 98.7%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 7,420.7
bar=donor   line=cohort median 		7,011.1 6,938.4 58.3%
17 MT-CO2 protein_coding 9,508.9
bar=donor   line=cohort median 		5,968.9 5,810.8 89.9%
18 MT-ND1 protein_coding 5,627.0
bar=donor   line=cohort median 		3,670.4 3,718.2 85.8%
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