GSM6881290

Dataset: gse221521 • Sample: DM group RNA334 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

14,489,540 Total counts Group median: 12,709,871 • 88.3%ile (↑ High)
26,608 Detected genes Group median: 2,638 • 54.1%ile (≈ Median)
9 Mitochondrial fraction (%) Group median: 6 • 90.9%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

43.3Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.46
bar=donor   line=cohort median 		0.17 96.6%
FOXO3 Insulin/IGF-1 Signaling 7.76
bar=donor   line=cohort median 		12.92 12.7%
CETP Lipid Metabolism 0.55
bar=donor   line=cohort median 		0.40 77.5%
SIRT6 Sirtuin Family 4.00
bar=donor   line=cohort median 		3.67 65.5%
SIRT1 Sirtuin Family 2.96
bar=donor   line=cohort median 		3.48 25.1%
SIRT3 Sirtuin Family 1.47
bar=donor   line=cohort median 		1.10 92.5%
IGF1R Insulin/IGF-1 Signaling 0.37
bar=donor   line=cohort median 		4.33 0.3%
KLOTHO Anti-aging 0.02
bar=donor   line=cohort median 		0.06 20.0%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.00
bar=donor   line=cohort median 		0.07 10.4%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 15.29
bar=donor   line=cohort median 		35.28 9.6%
TP53 Tumor Suppression 4.05
bar=donor   line=cohort median 		3.83 58.3%
SHC1 Signal Transduction 8.97
bar=donor   line=cohort median 		8.77 58.3%
ACE Signal Transduction 0.43
bar=donor   line=cohort median 		0.39 55.7%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 15,295.2 345,507
2 MT-CO2 ENSG00000198712 protein_coding 10,352.0 102,597
3 MT-RNR1 ENSG00000211459 Mt_rRNA 10,067.5 139,163
4 MT-CO3 ENSG00000198938 protein_coding 9,787.1 111,180
5 HBA1 ENSG00000206172 protein_coding 9,567.5 238,442
6 MT-CO1 ENSG00000198804 protein_coding 9,088.5 203,064
7 MT-ND3 ENSG00000198840 protein_coding 7,681.8 38,512
8 HBB ENSG00000244734 protein_coding 7,133.5 287,653
9 HBA2 ENSG00000188536 protein_coding 6,223.6 152,219
10 AC005912.1 ENSG00000227081 processed_pseudogene 6,144.5 22,703

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,110.5
bar=donor   line=cohort median 		1,568.6 1,385.4 31.9%
2 S100A9 protein_coding 5,860.8
bar=donor   line=cohort median 		10,144.6 9,235.1 19.4%
3 IL1B protein_coding 2.4
bar=donor   line=cohort median 		6.9 6.1 11.7%
4 CXCL8 protein_coding 164.1
bar=donor   line=cohort median 		225.8 207.4 35.5%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.2
bar=donor   line=cohort median 		2.2 2.4 22.0%
6 FCGR3B protein_coding 77.9
bar=donor   line=cohort median 		157.0 129.3 22.5%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 207.1
bar=donor   line=cohort median 		802.6 706.2 4.4%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 114.0
bar=donor   line=cohort median 		56.8 56.4 92.0%
9 CD3E protein_coding 65.8
bar=donor   line=cohort median 		36.9 37.7 88.9%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 1.0
bar=donor   line=cohort median 		3.2 3.1 2.8%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 832.9
bar=donor   line=cohort median 		296.3 281.6 99.7%
12 GNLY protein_coding 213.0
bar=donor   line=cohort median 		77.5 70.7 98.2%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 7,133.5
bar=donor   line=cohort median 		509.6 582.1 99.2%
14 HBA1 protein_coding 9,567.5
bar=donor   line=cohort median 		1,931.5 1,960.7 92.5%
15 HBA2 protein_coding 6,223.6
bar=donor   line=cohort median 		1,068.0 1,083.5 95.6%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 9,088.5
bar=donor   line=cohort median 		7,011.1 6,938.4 84.2%
17 MT-CO2 protein_coding 10,352.0
bar=donor   line=cohort median 		5,968.9 5,810.8 93.5%
18 MT-ND1 protein_coding 5,593.1
bar=donor   line=cohort median 		3,670.4 3,718.2 84.7%
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