GSM6881291

Dataset: gse221521 • Sample: DR group RNA335 • Status: Diabetic retinopathy
◂ Prev All Donors Next ▸

Quality Control Metrics

11,095,615 Total counts Group median: 12,498,211 • 10.6%ile (↓ Low)
26,285 Detected genes Group median: 27,368 • 42.7%ile (≈ Median)
9 Mitochondrial fraction (%) Group median: 6 • 91.5%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

53.2Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.41
bar=donor   line=cohort median 		0.17 94.6%
FOXO3 Insulin/IGF-1 Signaling 7.10
bar=donor   line=cohort median 		12.92 8.6%
CETP Lipid Metabolism 0.87
bar=donor   line=cohort median 		0.40 94.6%
SIRT6 Sirtuin Family 3.94
bar=donor   line=cohort median 		3.67 61.9%
SIRT1 Sirtuin Family 2.84
bar=donor   line=cohort median 		3.48 20.5%
SIRT3 Sirtuin Family 1.67
bar=donor   line=cohort median 		1.10 97.7%
IGF1R Insulin/IGF-1 Signaling 2.53
bar=donor   line=cohort median 		4.33 27.7%
KLOTHO Anti-aging 0.01
bar=donor   line=cohort median 		0.06 17.9%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.07
bar=donor   line=cohort median 		0.07 52.1%
TERT Telomere Maintenance 0.01
bar=donor   line=cohort median 		0.01 49.5%
IRS2 Insulin/IGF-1 Signaling 17.38
bar=donor   line=cohort median 		35.28 13.2%
TP53 Tumor Suppression 4.00
bar=donor   line=cohort median 		3.83 56.7%
SHC1 Signal Transduction 9.09
bar=donor   line=cohort median 		8.77 61.9%
ACE Signal Transduction 0.89
bar=donor   line=cohort median 		0.39 93.0%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 HBA1 ENSG00000206172 protein_coding 24,352.1 464,746
2 MT-RNR2 ENSG00000210082 Mt_rRNA 15,544.7 268,893
3 HBA2 ENSG00000188536 protein_coding 12,622.0 236,402
4 MT-RNR1 ENSG00000211459 Mt_rRNA 10,674.5 112,992
5 MT-CO2 ENSG00000198712 protein_coding 9,944.4 75,472
6 MT-CO3 ENSG00000198938 protein_coding 8,729.7 75,939
7 MT-CO1 ENSG00000198804 protein_coding 8,696.3 148,788
8 HBB ENSG00000244734 protein_coding 6,306.4 194,737
9 MT-ND1 ENSG00000198888 protein_coding 6,157.1 65,311
10 MT-ND3 ENSG00000198840 protein_coding 5,347.1 20,528

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 433.6
bar=donor   line=cohort median 		1,223.7 1,385.4 4.9%
2 S100A9 protein_coding 2,294.7
bar=donor   line=cohort median 		7,732.1 9,235.1 4.4%
3 IL1B protein_coding 0.4
bar=donor   line=cohort median 		4.9 6.1 1.3%
4 CXCL8 protein_coding 29.8
bar=donor   line=cohort median 		197.4 207.4 5.4%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.5
bar=donor   line=cohort median 		2.9 2.4 29.8%
6 FCGR3B protein_coding 24.7
bar=donor   line=cohort median 		108.9 129.3 4.9%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 173.3
bar=donor   line=cohort median 		581.4 706.2 1.8%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 90.1
bar=donor   line=cohort median 		51.6 56.4 84.2%
9 CD3E protein_coding 71.8
bar=donor   line=cohort median 		38.1 37.7 91.5%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 4.2
bar=donor   line=cohort median 		3.0 3.1 74.4%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 618.2
bar=donor   line=cohort median 		252.2 281.6 94.6%
12 GNLY protein_coding 205.6
bar=donor   line=cohort median 		58.9 70.7 97.2%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 6,306.4
bar=donor   line=cohort median 		585.0 582.1 98.7%
14 HBA1 protein_coding 24,352.1
bar=donor   line=cohort median 		1,960.4 1,960.7 99.7%
15 HBA2 protein_coding 12,622.0
bar=donor   line=cohort median 		1,080.5 1,083.5 99.7%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 8,696.3
bar=donor   line=cohort median 		6,740.9 6,938.4 80.6%
17 MT-CO2 protein_coding 9,944.4
bar=donor   line=cohort median 		5,693.7 5,810.8 92.5%
18 MT-ND1 protein_coding 6,157.1
bar=donor   line=cohort median 		3,876.8 3,718.2 89.9%
◂ Previous Donor Back to Donor List Next Donor ▸