GSM6881292

Dataset: gse221521 • Sample: DM group RNA336 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

12,738,864 Total counts Group median: 12,709,871 • 54.1%ile (≈ Median)
26,068 Detected genes Group median: 2,638 • 36.0%ile (≈ Median)
7 Mitochondrial fraction (%) Group median: 6 • 69.2%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

60.2Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.08
bar=donor   line=cohort median 		0.17 24.6%
FOXO3 Insulin/IGF-1 Signaling 13.63
bar=donor   line=cohort median 		12.92 55.2%
CETP Lipid Metabolism 0.43
bar=donor   line=cohort median 		0.40 57.3%
SIRT6 Sirtuin Family 4.09
bar=donor   line=cohort median 		3.67 71.2%
SIRT1 Sirtuin Family 3.14
bar=donor   line=cohort median 		3.48 33.4%
SIRT3 Sirtuin Family 1.26
bar=donor   line=cohort median 		1.10 70.7%
IGF1R Insulin/IGF-1 Signaling 6.15
bar=donor   line=cohort median 		4.33 79.5%
KLOTHO Anti-aging 0.06
bar=donor   line=cohort median 		0.06 43.8%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.11
bar=donor   line=cohort median 		0.07 73.8%
TERT Telomere Maintenance 0.05
bar=donor   line=cohort median 		0.01 89.4%
IRS2 Insulin/IGF-1 Signaling 36.30
bar=donor   line=cohort median 		35.28 52.6%
TP53 Tumor Suppression 5.14
bar=donor   line=cohort median 		3.83 80.6%
SHC1 Signal Transduction 8.76
bar=donor   line=cohort median 		8.77 49.5%
ACE Signal Transduction 0.51
bar=donor   line=cohort median 		0.39 72.3%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 11,499.9 228,386
2 S100A9 ENSG00000163220 protein_coding 10,166.9 74,212
3 HBA1 ENSG00000206172 protein_coding 9,090.2 199,175
4 MT-RNR1 ENSG00000211459 Mt_rRNA 7,417.9 90,149
5 MT-CO3 ENSG00000198938 protein_coding 7,175.7 71,666
6 MT-CO2 ENSG00000198712 protein_coding 7,049.2 61,422
7 MT-CO1 ENSG00000198804 protein_coding 6,353.8 124,810
8 HBA2 ENSG00000188536 protein_coding 5,616.8 120,780
9 MT-ND1 ENSG00000198888 protein_coding 5,159.2 62,830
10 FTL ENSG00000087086 protein_coding 5,140.9 57,041

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,596.5
bar=donor   line=cohort median 		1,568.6 1,385.4 57.3%
2 S100A9 protein_coding 10,166.9
bar=donor   line=cohort median 		10,144.6 9,235.1 58.8%
3 IL1B protein_coding 6.6
bar=donor   line=cohort median 		6.9 6.1 56.2%
4 CXCL8 protein_coding 198.7
bar=donor   line=cohort median 		225.8 207.4 46.9%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 0.9
bar=donor   line=cohort median 		2.2 2.4 12.7%
6 FCGR3B protein_coding 398.9
bar=donor   line=cohort median 		157.0 129.3 96.1%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 183.3
bar=donor   line=cohort median 		802.6 706.2 2.3%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 82.9
bar=donor   line=cohort median 		56.8 56.4 78.5%
9 CD3E protein_coding 57.5
bar=donor   line=cohort median 		36.9 37.7 85.8%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.0
bar=donor   line=cohort median 		3.2 3.1 46.9%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 402.6
bar=donor   line=cohort median 		296.3 281.6 76.9%
12 GNLY protein_coding 58.9
bar=donor   line=cohort median 		77.5 70.7 36.0%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 2,163.3
bar=donor   line=cohort median 		509.6 582.1 93.0%
14 HBA1 protein_coding 9,090.2
bar=donor   line=cohort median 		1,931.5 1,960.7 90.9%
15 HBA2 protein_coding 5,616.8
bar=donor   line=cohort median 		1,068.0 1,083.5 94.6%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 6,353.8
bar=donor   line=cohort median 		7,011.1 6,938.4 38.6%
17 MT-CO2 protein_coding 7,049.2
bar=donor   line=cohort median 		5,968.9 5,810.8 69.7%
18 MT-ND1 protein_coding 5,159.2
bar=donor   line=cohort median 		3,670.4 3,718.2 80.1%
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