GSM6881293

Dataset: gse221521 • Sample: Control group RNA338 • Status: Healthy control
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Quality Control Metrics

13,106,933 Total counts Group median: 12,762,148 • 67.1%ile (≈ Median)
25,972 Detected genes Group median: 2,606 • 32.9%ile (≈ Median)
9 Mitochondrial fraction (%) Group median: 6 • 87.8%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

45.6Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.34
bar=donor   line=cohort median 		0.17 89.4%
FOXO3 Insulin/IGF-1 Signaling 6.88
bar=donor   line=cohort median 		12.92 7.5%
CETP Lipid Metabolism 0.59
bar=donor   line=cohort median 		0.40 82.1%
SIRT6 Sirtuin Family 3.12
bar=donor   line=cohort median 		3.67 22.0%
SIRT1 Sirtuin Family 4.15
bar=donor   line=cohort median 		3.48 74.9%
SIRT3 Sirtuin Family 1.29
bar=donor   line=cohort median 		1.10 78.5%
IGF1R Insulin/IGF-1 Signaling 3.20
bar=donor   line=cohort median 		4.33 36.0%
KLOTHO Anti-aging 0.03
bar=donor   line=cohort median 		0.06 27.2%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.00
bar=donor   line=cohort median 		0.07 10.4%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 14.89
bar=donor   line=cohort median 		35.28 8.6%
TP53 Tumor Suppression 3.78
bar=donor   line=cohort median 		3.83 47.4%
SHC1 Signal Transduction 9.38
bar=donor   line=cohort median 		8.77 69.7%
ACE Signal Transduction 0.47
bar=donor   line=cohort median 		0.39 63.0%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 11,200.1 228,859
2 MT-CO3 ENSG00000198938 protein_coding 9,996.7 102,724
3 MT-CO1 ENSG00000198804 protein_coding 9,987.2 201,851
4 MT-CO2 ENSG00000198712 protein_coding 8,753.9 78,480
5 HBA1 ENSG00000206172 protein_coding 7,757.1 174,876
6 MT-ND3 ENSG00000198840 protein_coding 7,473.4 33,892
7 MT-RNR1 ENSG00000211459 Mt_rRNA 7,358.1 92,006
8 RPS28P7 ENSG00000227097 processed_pseudogene 6,841.5 18,831
9 MT-ND1 ENSG00000198888 protein_coding 6,568.6 82,306
10 MT-ND4 ENSG00000198886 protein_coding 5,752.7 103,901

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 384.5
bar=donor   line=cohort median 		1,535.8 1,385.4 3.4%
2 S100A9 protein_coding 2,086.3
bar=donor   line=cohort median 		10,851.3 9,235.1 3.4%
3 IL1B protein_coding 0.7
bar=donor   line=cohort median 		5.6 6.1 3.9%
4 CXCL8 protein_coding 22.3
bar=donor   line=cohort median 		220.4 207.4 2.8%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 0.9
bar=donor   line=cohort median 		1.7 2.4 14.8%
6 FCGR3B protein_coding 11.7
bar=donor   line=cohort median 		145.0 129.3 2.3%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 190.7
bar=donor   line=cohort median 		709.1 706.2 3.4%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 121.7
bar=donor   line=cohort median 		66.1 56.4 93.0%
9 CD3E protein_coding 76.3
bar=donor   line=cohort median 		37.6 37.7 93.0%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.0
bar=donor   line=cohort median 		3.1 3.1 18.4%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 754.9
bar=donor   line=cohort median 		302.3 281.6 98.2%
12 GNLY protein_coding 167.5
bar=donor   line=cohort median 		80.1 70.7 92.5%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 1,828.8
bar=donor   line=cohort median 		598.7 582.1 89.9%
14 HBA1 protein_coding 7,757.1
bar=donor   line=cohort median 		2,133.6 1,960.7 90.4%
15 HBA2 protein_coding 5,125.4
bar=donor   line=cohort median 		1,142.2 1,083.5 92.5%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 9,987.2
bar=donor   line=cohort median 		6,862.1 6,938.4 92.5%
17 MT-CO2 protein_coding 8,753.9
bar=donor   line=cohort median 		6,023.6 5,810.8 84.7%
18 MT-ND1 protein_coding 6,568.6
bar=donor   line=cohort median 		3,656.3 3,718.2 92.5%
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