GSM6881296

Dataset: gse221521 • Sample: Control group RNA345 • Status: Healthy control
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Quality Control Metrics

13,726,098 Total counts Group median: 12,762,148 • 81.1%ile (↑ High)
28,866 Detected genes Group median: 2,606 • 97.2%ile (↑ High)
5 Mitochondrial fraction (%) Group median: 6 • 25.6%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

55.4Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.14
bar=donor   line=cohort median 		0.17 43.3%
FOXO3 Insulin/IGF-1 Signaling 15.44
bar=donor   line=cohort median 		12.92 68.1%
CETP Lipid Metabolism 0.34
bar=donor   line=cohort median 		0.40 37.1%
SIRT6 Sirtuin Family 3.34
bar=donor   line=cohort median 		3.67 30.3%
SIRT1 Sirtuin Family 4.31
bar=donor   line=cohort median 		3.48 77.5%
SIRT3 Sirtuin Family 1.13
bar=donor   line=cohort median 		1.10 54.7%
IGF1R Insulin/IGF-1 Signaling 5.69
bar=donor   line=cohort median 		4.33 74.4%
KLOTHO Anti-aging 0.10
bar=donor   line=cohort median 		0.06 69.7%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.18
bar=donor   line=cohort median 		0.07 86.3%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 49.86
bar=donor   line=cohort median 		35.28 72.8%
TP53 Tumor Suppression 4.01
bar=donor   line=cohort median 		3.83 57.8%
SHC1 Signal Transduction 8.86
bar=donor   line=cohort median 		8.77 53.1%
ACE Signal Transduction 0.32
bar=donor   line=cohort median 		0.39 39.1%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 7,465.2 58,714
2 MT-RNR2 ENSG00000210082 Mt_rRNA 7,174.7 153,532
3 MT-CO1 ENSG00000198804 protein_coding 5,646.7 119,516
4 MT-CO2 ENSG00000198712 protein_coding 3,856.8 36,210
5 MT-ND1 ENSG00000198888 protein_coding 3,717.3 48,779
6 MT-CO3 ENSG00000198938 protein_coding 3,685.6 39,662
7 MT-ND4 ENSG00000198886 protein_coding 3,623.2 68,532
8 MT-ATP8 ENSG00000228253 protein_coding 3,492.1 9,922
9 MT-ND2 ENSG00000198763 protein_coding 3,435.7 49,140
10 MT-ND4L ENSG00000212907 protein_coding 3,298.5 13,447

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,662.9
bar=donor   line=cohort median 		1,535.8 1,385.4 59.8%
2 S100A9 protein_coding 7,465.2
bar=donor   line=cohort median 		10,851.3 9,235.1 36.0%
3 IL1B protein_coding 8.0
bar=donor   line=cohort median 		5.6 6.1 66.6%
4 CXCL8 protein_coding 329.0
bar=donor   line=cohort median 		220.4 207.4 73.3%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 2.5
bar=donor   line=cohort median 		1.7 2.4 55.2%
6 FCGR3B protein_coding 85.6
bar=donor   line=cohort median 		145.0 129.3 26.2%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 535.8
bar=donor   line=cohort median 		709.1 706.2 32.9%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 67.1
bar=donor   line=cohort median 		66.1 56.4 65.0%
9 CD3E protein_coding 39.0
bar=donor   line=cohort median 		37.6 37.7 53.6%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 5.5
bar=donor   line=cohort median 		3.1 3.1 86.3%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 375.7
bar=donor   line=cohort median 		302.3 281.6 74.4%
12 GNLY protein_coding 112.7
bar=donor   line=cohort median 		80.1 70.7 77.5%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 234.8
bar=donor   line=cohort median 		598.7 582.1 18.9%
14 HBA1 protein_coding 858.4
bar=donor   line=cohort median 		2,133.6 1,960.7 21.5%
15 HBA2 protein_coding 564.7
bar=donor   line=cohort median 		1,142.2 1,083.5 27.2%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 5,646.7
bar=donor   line=cohort median 		6,862.1 6,938.4 25.1%
17 MT-CO2 protein_coding 3,856.8
bar=donor   line=cohort median 		6,023.6 5,810.8 10.1%
18 MT-ND1 protein_coding 3,717.3
bar=donor   line=cohort median 		3,656.3 3,718.2 49.5%
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