GSM6881297

Dataset: gse221521 • Sample: DM group RNA35 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

13,506,866 Total counts Group median: 12,709,871 • 78.0%ile (↑ High)
26,595 Detected genes Group median: 2,638 • 53.6%ile (≈ Median)
4 Mitochondrial fraction (%) Group median: 6 • 13.7%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

55.7Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.18
bar=donor   line=cohort median 		0.17 53.6%
FOXO3 Insulin/IGF-1 Signaling 11.38
bar=donor   line=cohort median 		12.92 35.0%
CETP Lipid Metabolism 0.30
bar=donor   line=cohort median 		0.40 28.2%
SIRT6 Sirtuin Family 3.78
bar=donor   line=cohort median 		3.67 55.7%
SIRT1 Sirtuin Family 5.01
bar=donor   line=cohort median 		3.48 88.9%
SIRT3 Sirtuin Family 1.16
bar=donor   line=cohort median 		1.10 59.3%
IGF1R Insulin/IGF-1 Signaling 3.32
bar=donor   line=cohort median 		4.33 37.1%
KLOTHO Anti-aging 0.07
bar=donor   line=cohort median 		0.06 51.6%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.10
bar=donor   line=cohort median 		0.07 72.8%
TERT Telomere Maintenance 0.02
bar=donor   line=cohort median 		0.01 53.6%
IRS2 Insulin/IGF-1 Signaling 29.86
bar=donor   line=cohort median 		35.28 40.7%
TP53 Tumor Suppression 5.37
bar=donor   line=cohort median 		3.83 82.6%
SHC1 Signal Transduction 9.28
bar=donor   line=cohort median 		8.77 66.1%
ACE Signal Transduction 0.46
bar=donor   line=cohort median 		0.39 61.4%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 11,479.8 88,847
2 MT-CO1 ENSG00000198804 protein_coding 6,476.9 134,899
3 TMSB4XP8 ENSG00000187653 processed_pseudogene 5,095.9 9,292
4 MT-CO3 ENSG00000198938 protein_coding 4,927.3 52,177
5 MT-RNR2 ENSG00000210082 Mt_rRNA 4,818.1 101,456
6 MT-CO2 ENSG00000198712 protein_coding 4,718.2 43,590
7 FTL ENSG00000087086 protein_coding 4,328.9 50,927
8 MT-ND4 ENSG00000198886 protein_coding 2,893.8 53,860
9 EEF1A1P5 ENSG00000196205 processed_pseudogene 2,810.0 52,719
10 MT-ND1 ENSG00000198888 protein_coding 2,614.8 33,764

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,407.6
bar=donor   line=cohort median 		1,568.6 1,385.4 51.0%
2 S100A9 protein_coding 11,479.8
bar=donor   line=cohort median 		10,144.6 9,235.1 65.0%
3 IL1B protein_coding 15.9
bar=donor   line=cohort median 		6.9 6.1 91.5%
4 CXCL8 protein_coding 284.6
bar=donor   line=cohort median 		225.8 207.4 63.0%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 3.0
bar=donor   line=cohort median 		2.2 2.4 64.5%
6 FCGR3B protein_coding 173.8
bar=donor   line=cohort median 		157.0 129.3 67.1%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 2,034.7
bar=donor   line=cohort median 		802.6 706.2 98.2%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 49.7
bar=donor   line=cohort median 		56.8 56.4 40.7%
9 CD3E protein_coding 34.1
bar=donor   line=cohort median 		36.9 37.7 39.6%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.5
bar=donor   line=cohort median 		3.2 3.1 62.4%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 221.4
bar=donor   line=cohort median 		296.3 281.6 29.8%
12 GNLY protein_coding 61.2
bar=donor   line=cohort median 		77.5 70.7 38.1%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 460.8
bar=donor   line=cohort median 		509.6 582.1 40.7%
14 HBA1 protein_coding 2,062.3
bar=donor   line=cohort median 		1,931.5 1,960.7 52.1%
15 HBA2 protein_coding 1,890.7
bar=donor   line=cohort median 		1,068.0 1,083.5 69.2%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 6,476.9
bar=donor   line=cohort median 		7,011.1 6,938.4 40.2%
17 MT-CO2 protein_coding 4,718.2
bar=donor   line=cohort median 		5,968.9 5,810.8 21.5%
18 MT-ND1 protein_coding 2,614.8
bar=donor   line=cohort median 		3,670.4 3,718.2 17.9%
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