GSM6881298

Dataset: gse221521 • Sample: DM group RNA358 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

10,086,289 Total counts Group median: 12,709,871 • 4.9%ile (↓ Low)
26,386 Detected genes Group median: 2,638 • 45.3%ile (≈ Median)
7 Mitochondrial fraction (%) Group median: 6 • 78.0%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

54.2Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.03
bar=donor   line=cohort median 		0.17 13.2%
FOXO3 Insulin/IGF-1 Signaling 12.87
bar=donor   line=cohort median 		12.92 47.9%
CETP Lipid Metabolism 0.65
bar=donor   line=cohort median 		0.40 86.3%
SIRT6 Sirtuin Family 3.45
bar=donor   line=cohort median 		3.67 37.1%
SIRT1 Sirtuin Family 4.05
bar=donor   line=cohort median 		3.48 71.8%
SIRT3 Sirtuin Family 1.01
bar=donor   line=cohort median 		1.10 33.9%
IGF1R Insulin/IGF-1 Signaling 5.55
bar=donor   line=cohort median 		4.33 71.2%
KLOTHO Anti-aging 0.10
bar=donor   line=cohort median 		0.06 73.3%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.02
bar=donor   line=cohort median 		0.07 26.2%
TERT Telomere Maintenance 0.01
bar=donor   line=cohort median 		0.01 50.5%
IRS2 Insulin/IGF-1 Signaling 25.59
bar=donor   line=cohort median 		35.28 32.4%
TP53 Tumor Suppression 3.26
bar=donor   line=cohort median 		3.83 30.8%
SHC1 Signal Transduction 10.46
bar=donor   line=cohort median 		8.77 92.0%
ACE Signal Transduction 1.13
bar=donor   line=cohort median 		0.39 98.2%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 9,676.7 152,162
2 MT-CO1 ENSG00000198804 protein_coding 8,866.1 137,895
3 MT-CO2 ENSG00000198712 protein_coding 7,758.5 53,526
4 S100A9 ENSG00000163220 protein_coding 7,210.0 41,670
5 MT-ATP6 ENSG00000198899 protein_coding 6,961.1 47,814
6 MT-CO3 ENSG00000198938 protein_coding 5,675.6 44,881
7 MT-ATP8 ENSG00000228253 protein_coding 5,637.8 11,771
8 MT-RNR1 ENSG00000211459 Mt_rRNA 5,114.5 49,213
9 MT-ND1 ENSG00000198888 protein_coding 4,257.6 41,054
10 MT-ND4 ENSG00000198886 protein_coding 4,228.7 58,774

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,208.7
bar=donor   line=cohort median 		1,568.6 1,385.4 37.0%
2 S100A9 protein_coding 7,210.0
bar=donor   line=cohort median 		10,144.6 9,235.1 33.4%
3 IL1B protein_coding 10.2
bar=donor   line=cohort median 		6.9 6.1 77.5%
4 CXCL8 protein_coding 98.0
bar=donor   line=cohort median 		225.8 207.4 18.4%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.6
bar=donor   line=cohort median 		2.2 2.4 31.9%
6 FCGR3B protein_coding 97.1
bar=donor   line=cohort median 		157.0 129.3 32.4%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,071.6
bar=donor   line=cohort median 		802.6 706.2 76.4%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 59.9
bar=donor   line=cohort median 		56.8 56.4 55.7%
9 CD3E protein_coding 38.3
bar=donor   line=cohort median 		36.9 37.7 52.1%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 4.3
bar=donor   line=cohort median 		3.2 3.1 75.4%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 251.3
bar=donor   line=cohort median 		296.3 281.6 41.2%
12 GNLY protein_coding 69.2
bar=donor   line=cohort median 		77.5 70.7 46.9%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 239.6
bar=donor   line=cohort median 		509.6 582.1 19.4%
14 HBA1 protein_coding 601.3
bar=donor   line=cohort median 		1,931.5 1,960.7 10.6%
15 HBA2 protein_coding 324.7
bar=donor   line=cohort median 		1,068.0 1,083.5 12.2%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 8,866.1
bar=donor   line=cohort median 		7,011.1 6,938.4 82.6%
17 MT-CO2 protein_coding 7,758.5
bar=donor   line=cohort median 		5,968.9 5,810.8 75.9%
18 MT-ND1 protein_coding 4,257.6
bar=donor   line=cohort median 		3,670.4 3,718.2 67.1%
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