GSM6881299

Dataset: gse221521 • Sample: Control group RNA364 • Status: Healthy control
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Quality Control Metrics

11,098,269 Total counts Group median: 12,762,148 • 11.1%ile (↓ Low)
27,088 Detected genes Group median: 2,606 • 69.2%ile (≈ Median)
6 Mitochondrial fraction (%) Group median: 6 • 49.5%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

53.0Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.10
bar=donor   line=cohort median 		0.17 30.3%
FOXO3 Insulin/IGF-1 Signaling 13.22
bar=donor   line=cohort median 		12.92 52.1%
CETP Lipid Metabolism 0.57
bar=donor   line=cohort median 		0.40 80.1%
SIRT6 Sirtuin Family 3.22
bar=donor   line=cohort median 		3.67 24.6%
SIRT1 Sirtuin Family 4.37
bar=donor   line=cohort median 		3.48 79.5%
SIRT3 Sirtuin Family 1.07
bar=donor   line=cohort median 		1.10 43.8%
IGF1R Insulin/IGF-1 Signaling 5.43
bar=donor   line=cohort median 		4.33 68.7%
KLOTHO Anti-aging 0.20
bar=donor   line=cohort median 		0.06 95.6%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.09
bar=donor   line=cohort median 		0.07 62.4%
TERT Telomere Maintenance 0.01
bar=donor   line=cohort median 		0.01 49.0%
IRS2 Insulin/IGF-1 Signaling 31.40
bar=donor   line=cohort median 		35.28 42.8%
TP53 Tumor Suppression 3.60
bar=donor   line=cohort median 		3.83 40.7%
SHC1 Signal Transduction 8.71
bar=donor   line=cohort median 		8.77 46.9%
ACE Signal Transduction 0.27
bar=donor   line=cohort median 		0.39 30.3%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 11,622.3 73,910
2 MT-RNR2 ENSG00000210082 Mt_rRNA 8,536.1 147,694
3 MT-CO1 ENSG00000198804 protein_coding 7,164.9 122,616
4 MT-CO2 ENSG00000198712 protein_coding 6,467.2 49,094
5 MT-CO3 ENSG00000198938 protein_coding 5,315.3 46,249
6 MT-ATP8 ENSG00000228253 protein_coding 5,115.9 11,753
7 FTL ENSG00000087086 protein_coding 4,314.0 41,702
8 MT-RNR1 ENSG00000211459 Mt_rRNA 3,962.3 41,952
9 MT-ND4 ENSG00000198886 protein_coding 3,904.0 59,706
10 MT-ND4L ENSG00000212907 protein_coding 3,660.6 12,066

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 2,329.8
bar=donor   line=cohort median 		1,535.8 1,385.4 83.7%
2 S100A9 protein_coding 11,622.3
bar=donor   line=cohort median 		10,851.3 9,235.1 66.1%
3 IL1B protein_coding 37.0
bar=donor   line=cohort median 		5.6 6.1 99.7%
4 CXCL8 protein_coding 215.4
bar=donor   line=cohort median 		220.4 207.4 52.1%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 15.2
bar=donor   line=cohort median 		1.7 2.4 98.2%
6 FCGR3B protein_coding 181.5
bar=donor   line=cohort median 		145.0 129.3 70.2%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,845.8
bar=donor   line=cohort median 		709.1 706.2 97.7%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 34.5
bar=donor   line=cohort median 		66.1 56.4 14.2%
9 CD3E protein_coding 28.5
bar=donor   line=cohort median 		37.6 37.7 22.0%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.0
bar=donor   line=cohort median 		3.1 3.1 45.9%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 232.7
bar=donor   line=cohort median 		302.3 281.6 33.9%
12 GNLY protein_coding 82.9
bar=donor   line=cohort median 		80.1 70.7 59.3%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 245.2
bar=donor   line=cohort median 		598.7 582.1 20.5%
14 HBA1 protein_coding 929.6
bar=donor   line=cohort median 		2,133.6 1,960.7 24.1%
15 HBA2 protein_coding 507.7
bar=donor   line=cohort median 		1,142.2 1,083.5 22.5%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 7,164.9
bar=donor   line=cohort median 		6,862.1 6,938.4 54.1%
17 MT-CO2 protein_coding 6,467.2
bar=donor   line=cohort median 		6,023.6 5,810.8 63.5%
18 MT-ND1 protein_coding 3,606.7
bar=donor   line=cohort median 		3,656.3 3,718.2 45.3%
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