GSM6881301

Dataset: gse221521 • Sample: DM group RNA365 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

10,083,069 Total counts Group median: 12,709,871 • 4.4%ile (↓ Low)
25,935 Detected genes Group median: 2,638 • 31.3%ile (≈ Median)
6 Mitochondrial fraction (%) Group median: 6 • 57.8%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

54.2Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.08
bar=donor   line=cohort median 		0.17 21.5%
FOXO3 Insulin/IGF-1 Signaling 13.93
bar=donor   line=cohort median 		12.92 56.7%
CETP Lipid Metabolism 0.68
bar=donor   line=cohort median 		0.40 88.3%
SIRT6 Sirtuin Family 3.28
bar=donor   line=cohort median 		3.67 27.7%
SIRT1 Sirtuin Family 3.77
bar=donor   line=cohort median 		3.48 64.5%
SIRT3 Sirtuin Family 0.94
bar=donor   line=cohort median 		1.10 22.5%
IGF1R Insulin/IGF-1 Signaling 7.34
bar=donor   line=cohort median 		4.33 92.0%
KLOTHO Anti-aging 0.13
bar=donor   line=cohort median 		0.06 83.7%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.00
bar=donor   line=cohort median 		0.07 10.4%
TERT Telomere Maintenance 0.02
bar=donor   line=cohort median 		0.01 61.9%
IRS2 Insulin/IGF-1 Signaling 37.46
bar=donor   line=cohort median 		35.28 54.7%
TP53 Tumor Suppression 4.60
bar=donor   line=cohort median 		3.83 69.7%
SHC1 Signal Transduction 9.54
bar=donor   line=cohort median 		8.77 75.9%
ACE Signal Transduction 0.30
bar=donor   line=cohort median 		0.39 34.5%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 10,113.4 58,431
2 MT-RNR2 ENSG00000210082 Mt_rRNA 9,999.5 157,187
3 MT-CO1 ENSG00000198804 protein_coding 7,278.9 113,173
4 MT-CO3 ENSG00000198938 protein_coding 5,887.2 46,539
5 MT-CO2 ENSG00000198712 protein_coding 5,634.3 38,859
6 MT-ATP8 ENSG00000228253 protein_coding 5,206.0 10,866
7 MT-ND3 ENSG00000198840 protein_coding 4,429.1 15,452
8 FTL ENSG00000087086 protein_coding 4,292.1 37,695
9 MT-ND4 ENSG00000198886 protein_coding 3,995.4 55,514
10 MT-RNR1 ENSG00000211459 Mt_rRNA 3,972.8 38,215

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,716.8
bar=donor   line=cohort median 		1,568.6 1,385.4 64.0%
2 S100A9 protein_coding 10,113.4
bar=donor   line=cohort median 		10,144.6 9,235.1 57.3%
3 IL1B protein_coding 12.1
bar=donor   line=cohort median 		6.9 6.1 83.7%
4 CXCL8 protein_coding 233.0
bar=donor   line=cohort median 		225.8 207.4 54.1%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 2.0
bar=donor   line=cohort median 		2.2 2.4 45.3%
6 FCGR3B protein_coding 129.4
bar=donor   line=cohort median 		157.0 129.3 50.5%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,055.8
bar=donor   line=cohort median 		802.6 706.2 74.9%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 72.9
bar=donor   line=cohort median 		56.8 56.4 69.7%
9 CD3E protein_coding 38.2
bar=donor   line=cohort median 		36.9 37.7 51.6%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.7
bar=donor   line=cohort median 		3.2 3.1 37.0%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 353.5
bar=donor   line=cohort median 		296.3 281.6 69.7%
12 GNLY protein_coding 70.0
bar=donor   line=cohort median 		77.5 70.7 47.9%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 113.9
bar=donor   line=cohort median 		509.6 582.1 4.4%
14 HBA1 protein_coding 596.8
bar=donor   line=cohort median 		1,931.5 1,960.7 10.1%
15 HBA2 protein_coding 322.2
bar=donor   line=cohort median 		1,068.0 1,083.5 11.7%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 7,278.9
bar=donor   line=cohort median 		7,011.1 6,938.4 55.7%
17 MT-CO2 protein_coding 5,634.3
bar=donor   line=cohort median 		5,968.9 5,810.8 44.8%
18 MT-ND1 protein_coding 3,620.2
bar=donor   line=cohort median 		3,670.4 3,718.2 45.9%
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