GSM6881302

Dataset: gse221521 • Sample: DM group RNA368 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

13,108,435 Total counts Group median: 12,709,871 • 67.6%ile (≈ Median)
26,149 Detected genes Group median: 2,638 • 38.6%ile (≈ Median)
6 Mitochondrial fraction (%) Group median: 6 • 37.0%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

45.5Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.14
bar=donor   line=cohort median 		0.17 45.3%
FOXO3 Insulin/IGF-1 Signaling 10.42
bar=donor   line=cohort median 		12.92 24.6%
CETP Lipid Metabolism 0.50
bar=donor   line=cohort median 		0.40 69.7%
SIRT6 Sirtuin Family 5.27
bar=donor   line=cohort median 		3.67 95.6%
SIRT1 Sirtuin Family 3.29
bar=donor   line=cohort median 		3.48 39.1%
SIRT3 Sirtuin Family 1.26
bar=donor   line=cohort median 		1.10 71.2%
IGF1R Insulin/IGF-1 Signaling 2.39
bar=donor   line=cohort median 		4.33 24.6%
KLOTHO Anti-aging 0.00
bar=donor   line=cohort median 		0.06 5.2%
APOC3 Lipid Metabolism 0.05
bar=donor   line=cohort median 		0.00 97.7%
IL6 Inflammation 0.08
bar=donor   line=cohort median 		0.07 55.2%
TERT Telomere Maintenance 0.02
bar=donor   line=cohort median 		0.01 54.7%
IRS2 Insulin/IGF-1 Signaling 16.02
bar=donor   line=cohort median 		35.28 10.6%
TP53 Tumor Suppression 3.87
bar=donor   line=cohort median 		3.83 51.6%
SHC1 Signal Transduction 8.12
bar=donor   line=cohort median 		8.77 26.7%
ACE Signal Transduction 0.17
bar=donor   line=cohort median 		0.39 10.6%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 22,216.6 166,872
2 MT-RNR2 ENSG00000210082 Mt_rRNA 9,168.7 187,371
3 MT-RNR1 ENSG00000211459 Mt_rRNA 6,324.5 79,091
4 FTL ENSG00000087086 protein_coding 6,174.6 70,498
5 MT-CO2 ENSG00000198712 protein_coding 6,086.7 54,574
6 MT-ATP6 ENSG00000198899 protein_coding 5,544.5 49,495
7 MT-CO1 ENSG00000198804 protein_coding 4,759.1 96,197
8 MT-CO3 ENSG00000198938 protein_coding 4,657.7 47,867
9 TMSB4XP8 ENSG00000187653 processed_pseudogene 4,115.0 7,282
10 MT-ND3 ENSG00000198840 protein_coding 3,917.3 17,767

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 2,395.3
bar=donor   line=cohort median 		1,568.6 1,385.4 86.3%
2 S100A9 protein_coding 22,216.6
bar=donor   line=cohort median 		10,144.6 9,235.1 96.1%
3 IL1B protein_coding 25.5
bar=donor   line=cohort median 		6.9 6.1 98.7%
4 CXCL8 protein_coding 404.2
bar=donor   line=cohort median 		225.8 207.4 81.6%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 0.8
bar=donor   line=cohort median 		2.2 2.4 11.7%
6 FCGR3B protein_coding 401.4
bar=donor   line=cohort median 		157.0 129.3 96.6%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,354.4
bar=donor   line=cohort median 		802.6 706.2 87.3%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 84.9
bar=donor   line=cohort median 		56.8 56.4 81.1%
9 CD3E protein_coding 43.6
bar=donor   line=cohort median 		36.9 37.7 65.5%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.1
bar=donor   line=cohort median 		3.2 3.1 20.5%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 316.5
bar=donor   line=cohort median 		296.3 281.6 60.4%
12 GNLY protein_coding 67.3
bar=donor   line=cohort median 		77.5 70.7 42.7%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 138.9
bar=donor   line=cohort median 		509.6 582.1 7.5%
14 HBA1 protein_coding 401.6
bar=donor   line=cohort median 		1,931.5 1,960.7 3.4%
15 HBA2 protein_coding 305.8
bar=donor   line=cohort median 		1,068.0 1,083.5 10.1%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 4,759.1
bar=donor   line=cohort median 		7,011.1 6,938.4 10.6%
17 MT-CO2 protein_coding 6,086.7
bar=donor   line=cohort median 		5,968.9 5,810.8 55.2%
18 MT-ND1 protein_coding 2,495.2
bar=donor   line=cohort median 		3,670.4 3,718.2 13.2%
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