GSM6881303

Dataset: gse221521 • Sample: DM group RNA37 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

12,498,993 Total counts Group median: 12,709,871 • 45.9%ile (≈ Median)
27,232 Detected genes Group median: 2,638 • 71.2%ile (≈ Median)
4 Mitochondrial fraction (%) Group median: 6 • 8.0%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

49.4Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.11
bar=donor   line=cohort median 		0.17 33.9%
FOXO3 Insulin/IGF-1 Signaling 13.02
bar=donor   line=cohort median 		12.92 50.5%
CETP Lipid Metabolism 0.26
bar=donor   line=cohort median 		0.40 20.0%
SIRT6 Sirtuin Family 2.90
bar=donor   line=cohort median 		3.67 15.3%
SIRT1 Sirtuin Family 4.72
bar=donor   line=cohort median 		3.48 84.7%
SIRT3 Sirtuin Family 0.99
bar=donor   line=cohort median 		1.10 30.8%
IGF1R Insulin/IGF-1 Signaling 5.02
bar=donor   line=cohort median 		4.33 61.9%
KLOTHO Anti-aging 0.06
bar=donor   line=cohort median 		0.06 46.4%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.11
bar=donor   line=cohort median 		0.07 75.9%
TERT Telomere Maintenance 0.05
bar=donor   line=cohort median 		0.01 89.9%
IRS2 Insulin/IGF-1 Signaling 32.77
bar=donor   line=cohort median 		35.28 45.3%
TP53 Tumor Suppression 4.50
bar=donor   line=cohort median 		3.83 67.6%
SHC1 Signal Transduction 9.04
bar=donor   line=cohort median 		8.77 59.8%
ACE Signal Transduction 0.17
bar=donor   line=cohort median 		0.39 10.1%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 10,850.3 77,709
2 MT-CO1 ENSG00000198804 protein_coding 6,210.9 119,706
3 MT-RNR2 ENSG00000210082 Mt_rRNA 4,728.6 92,142
4 TMSB4XP8 ENSG00000187653 processed_pseudogene 4,499.9 7,593
5 FTL ENSG00000087086 protein_coding 4,303.8 46,854
6 MT-CO2 ENSG00000198712 protein_coding 3,609.9 30,862
7 MT-CO3 ENSG00000198938 protein_coding 3,256.9 31,915
8 H3P6 ENSG00000235655 processed_pseudogene 2,420.0 12,432
9 MT-ND1 ENSG00000198888 protein_coding 2,388.7 28,543
10 MT-ND4 ENSG00000198886 protein_coding 2,364.4 40,724

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,243.5
bar=donor   line=cohort median 		1,568.6 1,385.4 40.7%
2 S100A9 protein_coding 10,850.3
bar=donor   line=cohort median 		10,144.6 9,235.1 61.4%
3 IL1B protein_coding 21.6
bar=donor   line=cohort median 		6.9 6.1 96.6%
4 CXCL8 protein_coding 117.5
bar=donor   line=cohort median 		225.8 207.4 23.6%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 2.4
bar=donor   line=cohort median 		2.2 2.4 51.6%
6 FCGR3B protein_coding 102.9
bar=donor   line=cohort median 		157.0 129.3 35.5%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,194.1
bar=donor   line=cohort median 		802.6 706.2 81.6%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 18.1
bar=donor   line=cohort median 		56.8 56.4 1.8%
9 CD3E protein_coding 27.3
bar=donor   line=cohort median 		36.9 37.7 19.9%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.2
bar=donor   line=cohort median 		3.2 3.1 23.6%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 347.1
bar=donor   line=cohort median 		296.3 281.6 68.1%
12 GNLY protein_coding 96.7
bar=donor   line=cohort median 		77.5 70.7 66.6%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 501.1
bar=donor   line=cohort median 		509.6 582.1 45.9%
14 HBA1 protein_coding 1,016.1
bar=donor   line=cohort median 		1,931.5 1,960.7 26.7%
15 HBA2 protein_coding 912.7
bar=donor   line=cohort median 		1,068.0 1,083.5 43.3%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 6,210.9
bar=donor   line=cohort median 		7,011.1 6,938.4 35.0%
17 MT-CO2 protein_coding 3,609.9
bar=donor   line=cohort median 		5,968.9 5,810.8 7.0%
18 MT-ND1 protein_coding 2,388.7
bar=donor   line=cohort median 		3,670.4 3,718.2 11.7%
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