GSM6881304

Dataset: gse221521 • Sample: DR group RNA379 • Status: Diabetic retinopathy
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Quality Control Metrics

8,987,164 Total counts Group median: 12,498,211 • 0.8%ile (↓ Low)
25,675 Detected genes Group median: 27,368 • 24.1%ile (↓ Low)
6 Mitochondrial fraction (%) Group median: 6 • 45.3%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

49.4Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.21
bar=donor   line=cohort median 		0.17 63.5%
FOXO3 Insulin/IGF-1 Signaling 13.80
bar=donor   line=cohort median 		12.92 55.7%
CETP Lipid Metabolism 0.60
bar=donor   line=cohort median 		0.40 82.6%
SIRT6 Sirtuin Family 3.73
bar=donor   line=cohort median 		3.67 53.6%
SIRT1 Sirtuin Family 4.07
bar=donor   line=cohort median 		3.48 72.3%
SIRT3 Sirtuin Family 0.90
bar=donor   line=cohort median 		1.10 19.4%
IGF1R Insulin/IGF-1 Signaling 2.37
bar=donor   line=cohort median 		4.33 24.1%
KLOTHO Anti-aging 0.02
bar=donor   line=cohort median 		0.06 19.4%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.11
bar=donor   line=cohort median 		0.07 75.4%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 39.96
bar=donor   line=cohort median 		35.28 57.8%
TP53 Tumor Suppression 3.68
bar=donor   line=cohort median 		3.83 44.8%
SHC1 Signal Transduction 9.34
bar=donor   line=cohort median 		8.77 68.7%
ACE Signal Transduction 0.31
bar=donor   line=cohort median 		0.39 36.0%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 9,482.4 48,831
2 MT-RNR2 ENSG00000210082 Mt_rRNA 7,789.5 109,138
3 MT-CO1 ENSG00000198804 protein_coding 6,984.3 96,790
4 MT-CO2 ENSG00000198712 protein_coding 6,248.8 38,413
5 MT-ATP8 ENSG00000228253 protein_coding 5,211.9 9,696
6 MT-CO3 ENSG00000198938 protein_coding 4,962.6 34,966
7 MT-RNR1 ENSG00000211459 Mt_rRNA 4,125.6 35,372
8 FTL ENSG00000087086 protein_coding 3,924.1 30,717
9 MT-ND3 ENSG00000198840 protein_coding 3,670.3 11,413
10 MT-ND4L ENSG00000212907 protein_coding 3,589.5 9,581

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,260.9
bar=donor   line=cohort median 		1,223.7 1,385.4 41.7%
2 S100A9 protein_coding 9,482.4
bar=donor   line=cohort median 		7,732.1 9,235.1 51.0%
3 IL1B protein_coding 7.4
bar=donor   line=cohort median 		4.9 6.1 63.0%
4 CXCL8 protein_coding 91.2
bar=donor   line=cohort median 		197.4 207.4 17.9%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 0.9
bar=donor   line=cohort median 		2.9 2.4 12.2%
6 FCGR3B protein_coding 264.9
bar=donor   line=cohort median 		108.9 129.3 91.5%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,139.2
bar=donor   line=cohort median 		581.4 706.2 79.5%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 82.7
bar=donor   line=cohort median 		51.6 56.4 77.5%
9 CD3E protein_coding 48.3
bar=donor   line=cohort median 		38.1 37.7 74.4%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 1.6
bar=donor   line=cohort median 		3.0 3.1 8.5%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 414.5
bar=donor   line=cohort median 		252.2 281.6 78.5%
12 GNLY protein_coding 58.9
bar=donor   line=cohort median 		58.9 70.7 35.5%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 84.7
bar=donor   line=cohort median 		585.0 582.1 3.4%
14 HBA1 protein_coding 238.6
bar=donor   line=cohort median 		1,960.4 1,960.7 1.3%
15 HBA2 protein_coding 121.0
bar=donor   line=cohort median 		1,080.5 1,083.5 1.3%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 6,984.3
bar=donor   line=cohort median 		6,740.9 6,938.4 51.0%
17 MT-CO2 protein_coding 6,248.8
bar=donor   line=cohort median 		5,693.7 5,810.8 60.9%
18 MT-ND1 protein_coding 3,281.8
bar=donor   line=cohort median 		3,876.8 3,718.2 32.9%
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