GSM6881305

Dataset: gse221521 • Sample: DM group RNA38 • Status: Diabetes mellitus without diabetic retinopathy
◂ Prev All Donors Next ▸

Quality Control Metrics

13,438,724 Total counts Group median: 12,709,871 • 76.4%ile (↑ High)
25,608 Detected genes Group median: 2,638 • 22.0%ile (↓ Low)
3 Mitochondrial fraction (%) Group median: 6 • 1.3%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

34.0Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.16
bar=donor   line=cohort median 		0.17 47.4%
FOXO3 Insulin/IGF-1 Signaling 12.75
bar=donor   line=cohort median 		12.92 45.9%
CETP Lipid Metabolism 0.61
bar=donor   line=cohort median 		0.40 83.7%
SIRT6 Sirtuin Family 2.86
bar=donor   line=cohort median 		3.67 13.2%
SIRT1 Sirtuin Family 2.40
bar=donor   line=cohort median 		3.48 4.9%
SIRT3 Sirtuin Family 0.63
bar=donor   line=cohort median 		1.10 2.3%
IGF1R Insulin/IGF-1 Signaling 7.47
bar=donor   line=cohort median 		4.33 93.5%
KLOTHO Anti-aging 0.06
bar=donor   line=cohort median 		0.06 42.2%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.01
bar=donor   line=cohort median 		0.07 22.0%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 45.70
bar=donor   line=cohort median 		35.28 65.0%
TP53 Tumor Suppression 2.61
bar=donor   line=cohort median 		3.83 13.7%
SHC1 Signal Transduction 6.58
bar=donor   line=cohort median 		8.77 2.9%
ACE Signal Transduction 0.15
bar=donor   line=cohort median 		0.39 6.5%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 23,408.7 180,256
2 MT-RNR2 ENSG00000210082 Mt_rRNA 4,938.1 103,458
3 S100A8 ENSG00000143546 protein_coding 4,056.1 67,864
4 H3P6 ENSG00000235655 processed_pseudogene 3,863.6 21,340
5 TMSB4XP8 ENSG00000187653 processed_pseudogene 3,793.3 6,882
6 MT-CO1 ENSG00000198804 protein_coding 3,667.5 75,999
7 FTL ENSG00000087086 protein_coding 3,341.5 39,113
8 MT-CO3 ENSG00000198938 protein_coding 2,872.9 30,269
9 DUSP1 ENSG00000120129 protein_coding 2,781.9 75,257
10 MT-RNR1 ENSG00000211459 Mt_rRNA 2,493.7 31,970

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 4,056.1
bar=donor   line=cohort median 		1,568.6 1,385.4 99.2%
2 S100A9 protein_coding 23,408.7
bar=donor   line=cohort median 		10,144.6 9,235.1 98.2%
3 IL1B protein_coding 12.5
bar=donor   line=cohort median 		6.9 6.1 84.7%
4 CXCL8 protein_coding 85.9
bar=donor   line=cohort median 		225.8 207.4 15.3%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.5
bar=donor   line=cohort median 		2.2 2.4 30.3%
6 FCGR3B protein_coding 544.4
bar=donor   line=cohort median 		157.0 129.3 99.2%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,513.0
bar=donor   line=cohort median 		802.6 706.2 89.9%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 18.3
bar=donor   line=cohort median 		56.8 56.4 2.3%
9 CD3E protein_coding 13.9
bar=donor   line=cohort median 		36.9 37.7 2.3%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 1.9
bar=donor   line=cohort median 		3.2 3.1 15.3%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 56.0
bar=donor   line=cohort median 		296.3 281.6 1.3%
12 GNLY protein_coding 5.2
bar=donor   line=cohort median 		77.5 70.7 0.3%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 640.1
bar=donor   line=cohort median 		509.6 582.1 55.2%
14 HBA1 protein_coding 895.7
bar=donor   line=cohort median 		1,931.5 1,960.7 23.1%
15 HBA2 protein_coding 644.3
bar=donor   line=cohort median 		1,068.0 1,083.5 30.3%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 3,667.5
bar=donor   line=cohort median 		7,011.1 6,938.4 3.4%
17 MT-CO2 protein_coding 2,428.1
bar=donor   line=cohort median 		5,968.9 5,810.8 2.8%
18 MT-ND1 protein_coding 2,052.0
bar=donor   line=cohort median 		3,670.4 3,718.2 7.5%
◂ Previous Donor Back to Donor List Next Donor ▸