GSM6881308

Dataset: gse221521 • Sample: DR group RNA385 • Status: Diabetic retinopathy
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Quality Control Metrics

18,854,783 Total counts Group median: 12,498,211 • 98.7%ile (↑ High)
28,661 Detected genes Group median: 27,368 • 95.6%ile (↑ High)
5 Mitochondrial fraction (%) Group median: 6 • 18.9%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

46.2Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.17
bar=donor   line=cohort median 		0.17 51.6%
FOXO3 Insulin/IGF-1 Signaling 19.29
bar=donor   line=cohort median 		12.92 93.0%
CETP Lipid Metabolism 0.35
bar=donor   line=cohort median 		0.40 38.6%
SIRT6 Sirtuin Family 3.85
bar=donor   line=cohort median 		3.67 58.8%
SIRT1 Sirtuin Family 2.90
bar=donor   line=cohort median 		3.48 22.5%
SIRT3 Sirtuin Family 0.88
bar=donor   line=cohort median 		1.10 16.3%
IGF1R Insulin/IGF-1 Signaling 2.89
bar=donor   line=cohort median 		4.33 31.4%
KLOTHO Anti-aging 0.02
bar=donor   line=cohort median 		0.06 21.0%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.07
bar=donor   line=cohort median 		0.07 53.1%
TERT Telomere Maintenance 0.02
bar=donor   line=cohort median 		0.01 57.8%
IRS2 Insulin/IGF-1 Signaling 70.92
bar=donor   line=cohort median 		35.28 89.9%
TP53 Tumor Suppression 3.07
bar=donor   line=cohort median 		3.83 22.5%
SHC1 Signal Transduction 10.03
bar=donor   line=cohort median 		8.77 85.8%
ACE Signal Transduction 0.09
bar=donor   line=cohort median 		0.39 1.8%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 10,974.2 118,563
2 MT-RNR2 ENSG00000210082 Mt_rRNA 6,026.6 177,151
3 MT-CO2 ENSG00000198712 protein_coding 5,359.5 69,120
4 MT-ATP8 ENSG00000228253 protein_coding 5,008.8 19,549
5 MT-ATP6 ENSG00000198899 protein_coding 4,824.0 61,941
6 MT-CO1 ENSG00000198804 protein_coding 4,807.3 139,769
7 FTL ENSG00000087086 protein_coding 4,686.3 76,961
8 MT-CO3 ENSG00000198938 protein_coding 3,392.5 50,149
9 MT-ND4 ENSG00000198886 protein_coding 3,172.1 82,417
10 MT-RNR1 ENSG00000211459 Mt_rRNA 2,848.1 51,230

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,902.2
bar=donor   line=cohort median 		1,223.7 1,385.4 72.8%
2 S100A9 protein_coding 10,974.2
bar=donor   line=cohort median 		7,732.1 9,235.1 63.0%
3 IL1B protein_coding 4.3
bar=donor   line=cohort median 		4.9 6.1 30.3%
4 CXCL8 protein_coding 123.2
bar=donor   line=cohort median 		197.4 207.4 25.6%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 2.0
bar=donor   line=cohort median 		2.9 2.4 43.3%
6 FCGR3B protein_coding 114.7
bar=donor   line=cohort median 		108.9 129.3 39.1%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,525.5
bar=donor   line=cohort median 		581.4 706.2 90.4%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 48.6
bar=donor   line=cohort median 		51.6 56.4 36.0%
9 CD3E protein_coding 29.5
bar=donor   line=cohort median 		38.1 37.7 24.6%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.8
bar=donor   line=cohort median 		3.0 3.1 41.2%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 385.2
bar=donor   line=cohort median 		252.2 281.6 75.4%
12 GNLY protein_coding 108.9
bar=donor   line=cohort median 		58.9 70.7 76.4%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 535.1
bar=donor   line=cohort median 		585.0 582.1 47.9%
14 HBA1 protein_coding 1,215.8
bar=donor   line=cohort median 		1,960.4 1,960.7 34.5%
15 HBA2 protein_coding 733.7
bar=donor   line=cohort median 		1,080.5 1,083.5 33.9%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 4,807.3
bar=donor   line=cohort median 		6,740.9 6,938.4 11.1%
17 MT-CO2 protein_coding 5,359.5
bar=donor   line=cohort median 		5,693.7 5,810.8 37.6%
18 MT-ND1 protein_coding 2,543.2
bar=donor   line=cohort median 		3,876.8 3,718.2 14.8%
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