GSM6881309

Dataset: gse221521 • Sample: DM group RNA386 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

11,341,770 Total counts Group median: 12,709,871 • 14.2%ile (↓ Low)
26,719 Detected genes Group median: 2,638 • 59.3%ile (≈ Median)
6 Mitochondrial fraction (%) Group median: 6 • 58.8%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

48.6Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.30
bar=donor   line=cohort median 		0.17 82.6%
FOXO3 Insulin/IGF-1 Signaling 9.94
bar=donor   line=cohort median 		12.92 20.5%
CETP Lipid Metabolism 0.85
bar=donor   line=cohort median 		0.40 93.5%
SIRT6 Sirtuin Family 4.62
bar=donor   line=cohort median 		3.67 85.2%
SIRT1 Sirtuin Family 2.99
bar=donor   line=cohort median 		3.48 25.7%
SIRT3 Sirtuin Family 1.12
bar=donor   line=cohort median 		1.10 54.2%
IGF1R Insulin/IGF-1 Signaling 0.56
bar=donor   line=cohort median 		4.33 4.4%
KLOTHO Anti-aging 0.07
bar=donor   line=cohort median 		0.06 51.0%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.05
bar=donor   line=cohort median 		0.07 43.3%
TERT Telomere Maintenance 0.06
bar=donor   line=cohort median 		0.01 92.0%
IRS2 Insulin/IGF-1 Signaling 24.62
bar=donor   line=cohort median 		35.28 26.7%
TP53 Tumor Suppression 4.23
bar=donor   line=cohort median 		3.83 60.9%
SHC1 Signal Transduction 7.92
bar=donor   line=cohort median 		8.77 17.9%
ACE Signal Transduction 0.24
bar=donor   line=cohort median 		0.39 23.1%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 16,532.0 107,439
2 MT-RNR2 ENSG00000210082 Mt_rRNA 9,068.7 160,352
3 AC005912.1 ENSG00000227081 processed_pseudogene 8,257.5 23,882
4 MT-CO1 ENSG00000198804 protein_coding 7,789.7 136,234
5 MT-CO3 ENSG00000198938 protein_coding 7,466.6 66,393
6 HBA1 ENSG00000206172 protein_coding 7,364.1 143,658
7 MT-CO2 ENSG00000198712 protein_coding 7,051.8 54,706
8 MT-ND3 ENSG00000198840 protein_coding 5,681.1 22,294
9 MT-RNR1 ENSG00000211459 Mt_rRNA 5,235.1 56,644
10 FTL ENSG00000087086 protein_coding 4,975.4 49,150

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 3,151.6
bar=donor   line=cohort median 		1,568.6 1,385.4 95.6%
2 S100A9 protein_coding 16,532.0
bar=donor   line=cohort median 		10,144.6 9,235.1 87.3%
3 IL1B protein_coding 3.0
bar=donor   line=cohort median 		6.9 6.1 17.4%
4 CXCL8 protein_coding 172.1
bar=donor   line=cohort median 		225.8 207.4 36.5%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 2.0
bar=donor   line=cohort median 		2.2 2.4 43.8%
6 FCGR3B protein_coding 89.8
bar=donor   line=cohort median 		157.0 129.3 28.2%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,168.3
bar=donor   line=cohort median 		802.6 706.2 80.6%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 89.1
bar=donor   line=cohort median 		56.8 56.4 83.7%
9 CD3E protein_coding 48.8
bar=donor   line=cohort median 		36.9 37.7 75.4%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.4
bar=donor   line=cohort median 		3.2 3.1 28.8%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 341.3
bar=donor   line=cohort median 		296.3 281.6 66.6%
12 GNLY protein_coding 77.1
bar=donor   line=cohort median 		77.5 70.7 54.1%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 1,589.0
bar=donor   line=cohort median 		509.6 582.1 86.3%
14 HBA1 protein_coding 7,364.1
bar=donor   line=cohort median 		1,931.5 1,960.7 89.4%
15 HBA2 protein_coding 4,603.8
bar=donor   line=cohort median 		1,068.0 1,083.5 90.9%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 7,789.7
bar=donor   line=cohort median 		7,011.1 6,938.4 63.0%
17 MT-CO2 protein_coding 7,051.8
bar=donor   line=cohort median 		5,968.9 5,810.8 70.2%
18 MT-ND1 protein_coding 3,203.8
bar=donor   line=cohort median 		3,670.4 3,718.2 32.4%
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