GSM6881310

Dataset: gse221521 • Sample: DR group RNA39 • Status: Diabetic retinopathy
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Quality Control Metrics

12,119,917 Total counts Group median: 12,498,211 • 32.4%ile (≈ Median)
26,698 Detected genes Group median: 27,368 • 57.3%ile (≈ Median)
5 Mitochondrial fraction (%) Group median: 6 • 20.5%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

48.3Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.04
bar=donor   line=cohort median 		0.17 16.3%
FOXO3 Insulin/IGF-1 Signaling 16.00
bar=donor   line=cohort median 		12.92 73.3%
CETP Lipid Metabolism 0.62
bar=donor   line=cohort median 		0.40 84.2%
SIRT6 Sirtuin Family 2.90
bar=donor   line=cohort median 		3.67 15.8%
SIRT1 Sirtuin Family 4.66
bar=donor   line=cohort median 		3.48 84.2%
SIRT3 Sirtuin Family 0.71
bar=donor   line=cohort median 		1.10 6.0%
IGF1R Insulin/IGF-1 Signaling 6.55
bar=donor   line=cohort median 		4.33 82.6%
KLOTHO Anti-aging 0.06
bar=donor   line=cohort median 		0.06 48.5%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.03
bar=donor   line=cohort median 		0.07 31.9%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 63.57
bar=donor   line=cohort median 		35.28 84.7%
TP53 Tumor Suppression 3.99
bar=donor   line=cohort median 		3.83 56.2%
SHC1 Signal Transduction 8.02
bar=donor   line=cohort median 		8.77 22.0%
ACE Signal Transduction 0.39
bar=donor   line=cohort median 		0.39 51.0%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 9,427.5 65,471
2 MT-CO1 ENSG00000198804 protein_coding 6,740.9 125,980
3 MT-RNR2 ENSG00000210082 Mt_rRNA 6,738.7 127,327
4 TMSB4XP8 ENSG00000187653 processed_pseudogene 5,323.3 8,710
5 MT-CO2 ENSG00000198712 protein_coding 4,621.0 38,308
6 MT-CO3 ENSG00000198938 protein_coding 4,476.5 42,536
7 FTL ENSG00000087086 protein_coding 4,168.2 44,001
8 MT-RNR1 ENSG00000211459 Mt_rRNA 3,462.1 40,030
9 MT-ND1 ENSG00000198888 protein_coding 3,179.7 36,842
10 MT-ND4 ENSG00000198886 protein_coding 2,978.8 49,749

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,314.5
bar=donor   line=cohort median 		1,223.7 1,385.4 44.8%
2 S100A9 protein_coding 9,427.5
bar=donor   line=cohort median 		7,732.1 9,235.1 50.5%
3 IL1B protein_coding 13.7
bar=donor   line=cohort median 		4.9 6.1 89.9%
4 CXCL8 protein_coding 173.8
bar=donor   line=cohort median 		197.4 207.4 38.1%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 2.1
bar=donor   line=cohort median 		2.9 2.4 46.4%
6 FCGR3B protein_coding 202.9
bar=donor   line=cohort median 		108.9 129.3 76.9%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 920.0
bar=donor   line=cohort median 		581.4 706.2 68.1%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 45.5
bar=donor   line=cohort median 		51.6 56.4 31.9%
9 CD3E protein_coding 40.2
bar=donor   line=cohort median 		38.1 37.7 57.3%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.7
bar=donor   line=cohort median 		3.0 3.1 37.6%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 325.1
bar=donor   line=cohort median 		252.2 281.6 63.5%
12 GNLY protein_coding 140.6
bar=donor   line=cohort median 		58.9 70.7 89.4%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 444.5
bar=donor   line=cohort median 		585.0 582.1 38.6%
14 HBA1 protein_coding 881.6
bar=donor   line=cohort median 		1,960.4 1,960.7 22.5%
15 HBA2 protein_coding 758.4
bar=donor   line=cohort median 		1,080.5 1,083.5 36.0%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 6,740.9
bar=donor   line=cohort median 		6,740.9 6,938.4 44.8%
17 MT-CO2 protein_coding 4,621.0
bar=donor   line=cohort median 		5,693.7 5,810.8 18.9%
18 MT-ND1 protein_coding 3,179.7
bar=donor   line=cohort median 		3,876.8 3,718.2 31.3%
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