GSM6881311

Dataset: gse221521 • Sample: DM group RNA392 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

10,917,107 Total counts Group median: 12,709,871 • 8.5%ile (↓ Low)
26,594 Detected genes Group median: 2,638 • 53.1%ile (≈ Median)
6 Mitochondrial fraction (%) Group median: 6 • 46.9%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

48.6Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.02
bar=donor   line=cohort median 		0.17 12.7%
FOXO3 Insulin/IGF-1 Signaling 14.48
bar=donor   line=cohort median 		12.92 60.9%
CETP Lipid Metabolism 0.39
bar=donor   line=cohort median 		0.40 46.9%
SIRT6 Sirtuin Family 4.02
bar=donor   line=cohort median 		3.67 67.1%
SIRT1 Sirtuin Family 3.45
bar=donor   line=cohort median 		3.48 46.4%
SIRT3 Sirtuin Family 0.99
bar=donor   line=cohort median 		1.10 29.8%
IGF1R Insulin/IGF-1 Signaling 1.19
bar=donor   line=cohort median 		4.33 11.7%
KLOTHO Anti-aging 0.11
bar=donor   line=cohort median 		0.06 78.0%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.06
bar=donor   line=cohort median 		0.07 44.8%
TERT Telomere Maintenance 0.01
bar=donor   line=cohort median 		0.01 50.0%
IRS2 Insulin/IGF-1 Signaling 35.28
bar=donor   line=cohort median 		35.28 50.0%
TP53 Tumor Suppression 4.36
bar=donor   line=cohort median 		3.83 64.5%
SHC1 Signal Transduction 9.44
bar=donor   line=cohort median 		8.77 72.3%
ACE Signal Transduction 0.35
bar=donor   line=cohort median 		0.39 44.8%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 13,096.8 81,927
2 MT-RNR2 ENSG00000210082 Mt_rRNA 9,159.6 155,895
3 MT-CO1 ENSG00000198804 protein_coding 6,936.1 116,763
4 MT-CO2 ENSG00000198712 protein_coding 6,484.0 48,418
5 FTL ENSG00000087086 protein_coding 4,899.9 46,592
6 MT-CO3 ENSG00000198938 protein_coding 4,702.8 40,251
7 MT-RNR1 ENSG00000211459 Mt_rRNA 4,494.3 46,808
8 MT-ATP8 ENSG00000228253 protein_coding 4,376.9 9,891
9 MT-ND3 ENSG00000198840 protein_coding 3,713.0 14,025
10 MT-ND4 ENSG00000198886 protein_coding 3,440.8 51,762

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 2,295.3
bar=donor   line=cohort median 		1,568.6 1,385.4 82.1%
2 S100A9 protein_coding 13,096.8
bar=donor   line=cohort median 		10,144.6 9,235.1 76.4%
3 IL1B protein_coding 6.5
bar=donor   line=cohort median 		6.9 6.1 55.7%
4 CXCL8 protein_coding 246.9
bar=donor   line=cohort median 		225.8 207.4 57.3%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.4
bar=donor   line=cohort median 		2.2 2.4 27.2%
6 FCGR3B protein_coding 91.7
bar=donor   line=cohort median 		157.0 129.3 29.8%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 680.0
bar=donor   line=cohort median 		802.6 706.2 46.4%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 32.1
bar=donor   line=cohort median 		56.8 56.4 11.1%
9 CD3E protein_coding 17.6
bar=donor   line=cohort median 		36.9 37.7 3.9%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.7
bar=donor   line=cohort median 		3.2 3.1 38.6%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 309.2
bar=donor   line=cohort median 		296.3 281.6 58.8%
12 GNLY protein_coding 64.6
bar=donor   line=cohort median 		77.5 70.7 40.2%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 428.4
bar=donor   line=cohort median 		509.6 582.1 38.1%
14 HBA1 protein_coding 2,051.9
bar=donor   line=cohort median 		1,931.5 1,960.7 51.0%
15 HBA2 protein_coding 1,010.6
bar=donor   line=cohort median 		1,068.0 1,083.5 45.3%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 6,936.1
bar=donor   line=cohort median 		7,011.1 6,938.4 49.5%
17 MT-CO2 protein_coding 6,484.0
bar=donor   line=cohort median 		5,968.9 5,810.8 64.0%
18 MT-ND1 protein_coding 3,105.8
bar=donor   line=cohort median 		3,670.4 3,718.2 28.8%
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