GSM6881313

Dataset: gse221521 • Sample: Control group RNA396 • Status: Healthy control
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Quality Control Metrics

11,676,436 Total counts Group median: 12,762,148 • 19.9%ile (↓ Low)
25,993 Detected genes Group median: 2,606 • 33.4%ile (≈ Median)
7 Mitochondrial fraction (%) Group median: 6 • 62.4%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

49.9Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.18
bar=donor   line=cohort median 		0.17 55.2%
FOXO3 Insulin/IGF-1 Signaling 17.82
bar=donor   line=cohort median 		12.92 83.2%
CETP Lipid Metabolism 0.42
bar=donor   line=cohort median 		0.40 56.7%
SIRT6 Sirtuin Family 3.39
bar=donor   line=cohort median 		3.67 33.9%
SIRT1 Sirtuin Family 2.99
bar=donor   line=cohort median 		3.48 27.2%
SIRT3 Sirtuin Family 1.24
bar=donor   line=cohort median 		1.10 66.6%
IGF1R Insulin/IGF-1 Signaling 1.54
bar=donor   line=cohort median 		4.33 12.2%
KLOTHO Anti-aging 0.09
bar=donor   line=cohort median 		0.06 66.6%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.05
bar=donor   line=cohort median 		0.07 42.8%
TERT Telomere Maintenance 0.01
bar=donor   line=cohort median 		0.01 47.4%
IRS2 Insulin/IGF-1 Signaling 78.94
bar=donor   line=cohort median 		35.28 93.5%
TP53 Tumor Suppression 2.50
bar=donor   line=cohort median 		3.83 11.1%
SHC1 Signal Transduction 8.02
bar=donor   line=cohort median 		8.77 22.5%
ACE Signal Transduction 0.59
bar=donor   line=cohort median 		0.39 80.6%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 17,795.4 119,062
2 MT-RNR2 ENSG00000210082 Mt_rRNA 10,481.9 190,808
3 MT-CO1 ENSG00000198804 protein_coding 7,543.2 135,816
4 MT-CO2 ENSG00000198712 protein_coding 5,980.5 47,764
5 MT-CO3 ENSG00000198938 protein_coding 5,575.2 51,037
6 MT-RNR1 ENSG00000211459 Mt_rRNA 5,408.0 60,242
7 FTL ENSG00000087086 protein_coding 5,188.4 52,767
8 MT-ATP8 ENSG00000228253 protein_coding 5,174.1 12,506
9 MT-ND3 ENSG00000198840 protein_coding 4,156.9 16,794
10 MT-ND4 ENSG00000198886 protein_coding 4,156.0 66,870

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 3,152.9
bar=donor   line=cohort median 		1,535.8 1,385.4 96.1%
2 S100A9 protein_coding 17,795.4
bar=donor   line=cohort median 		10,851.3 9,235.1 90.9%
3 IL1B protein_coding 3.8
bar=donor   line=cohort median 		5.6 6.1 25.6%
4 CXCL8 protein_coding 176.9
bar=donor   line=cohort median 		220.4 207.4 40.2%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 0.7
bar=donor   line=cohort median 		1.7 2.4 9.1%
6 FCGR3B protein_coding 129.0
bar=donor   line=cohort median 		145.0 129.3 49.5%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,084.2
bar=donor   line=cohort median 		709.1 706.2 77.5%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 61.1
bar=donor   line=cohort median 		66.1 56.4 57.8%
9 CD3E protein_coding 31.4
bar=donor   line=cohort median 		37.6 37.7 29.8%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 1.7
bar=donor   line=cohort median 		3.1 3.1 10.1%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 242.8
bar=donor   line=cohort median 		302.3 281.6 36.0%
12 GNLY protein_coding 53.2
bar=donor   line=cohort median 		80.1 70.7 30.3%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 68.6
bar=donor   line=cohort median 		598.7 582.1 2.3%
14 HBA1 protein_coding 422.5
bar=donor   line=cohort median 		2,133.6 1,960.7 3.9%
15 HBA2 protein_coding 201.1
bar=donor   line=cohort median 		1,142.2 1,083.5 4.9%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 7,543.2
bar=donor   line=cohort median 		6,862.1 6,938.4 59.3%
17 MT-CO2 protein_coding 5,980.5
bar=donor   line=cohort median 		6,023.6 5,810.8 52.1%
18 MT-ND1 protein_coding 3,575.8
bar=donor   line=cohort median 		3,656.3 3,718.2 42.7%
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