GSM6881314

Dataset: gse221521 • Sample: Control group RNA400 • Status: Healthy control
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Quality Control Metrics

11,991,527 Total counts Group median: 12,762,148 • 25.6%ile (≈ Median)
26,290 Detected genes Group median: 2,606 • 43.3%ile (≈ Median)
5 Mitochondrial fraction (%) Group median: 6 • 24.1%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

48.7Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.35
bar=donor   line=cohort median 		0.17 90.9%
FOXO3 Insulin/IGF-1 Signaling 17.51
bar=donor   line=cohort median 		12.92 81.6%
CETP Lipid Metabolism 0.16
bar=donor   line=cohort median 		0.40 4.4%
SIRT6 Sirtuin Family 4.14
bar=donor   line=cohort median 		3.67 73.3%
SIRT1 Sirtuin Family 2.47
bar=donor   line=cohort median 		3.48 7.5%
SIRT3 Sirtuin Family 0.97
bar=donor   line=cohort median 		1.10 27.7%
IGF1R Insulin/IGF-1 Signaling 3.43
bar=donor   line=cohort median 		4.33 39.1%
KLOTHO Anti-aging 0.00
bar=donor   line=cohort median 		0.06 5.2%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.22
bar=donor   line=cohort median 		0.07 90.4%
TERT Telomere Maintenance 0.03
bar=donor   line=cohort median 		0.01 71.8%
IRS2 Insulin/IGF-1 Signaling 45.69
bar=donor   line=cohort median 		35.28 64.5%
TP53 Tumor Suppression 2.50
bar=donor   line=cohort median 		3.83 10.6%
SHC1 Signal Transduction 9.44
bar=donor   line=cohort median 		8.77 72.8%
ACE Signal Transduction 0.34
bar=donor   line=cohort median 		0.39 41.7%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 14,399.2 98,939
2 MT-RNR2 ENSG00000210082 Mt_rRNA 7,645.1 142,924
3 FTL ENSG00000087086 protein_coding 6,341.9 66,239
4 MT-CO2 ENSG00000198712 protein_coding 5,745.0 47,122
5 MT-CO1 ENSG00000198804 protein_coding 4,715.7 87,197
6 MT-ATP6 ENSG00000198899 protein_coding 4,522.9 36,935
7 MT-ATP8 ENSG00000228253 protein_coding 3,977.0 9,872
8 MT-RNR1 ENSG00000211459 Mt_rRNA 3,970.4 45,421
9 MT-CO3 ENSG00000198938 protein_coding 3,639.9 34,220
10 EEF1A1P5 ENSG00000196205 processed_pseudogene 2,912.2 48,506

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 2,548.0
bar=donor   line=cohort median 		1,535.8 1,385.4 87.8%
2 S100A9 protein_coding 14,399.2
bar=donor   line=cohort median 		10,851.3 9,235.1 80.1%
3 IL1B protein_coding 6.6
bar=donor   line=cohort median 		5.6 6.1 57.3%
4 CXCL8 protein_coding 436.3
bar=donor   line=cohort median 		220.4 207.4 86.3%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 2.5
bar=donor   line=cohort median 		1.7 2.4 52.1%
6 FCGR3B protein_coding 173.4
bar=donor   line=cohort median 		145.0 129.3 66.6%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,347.2
bar=donor   line=cohort median 		709.1 706.2 86.8%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 39.2
bar=donor   line=cohort median 		66.1 56.4 21.0%
9 CD3E protein_coding 23.3
bar=donor   line=cohort median 		37.6 37.7 10.6%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.4
bar=donor   line=cohort median 		3.1 3.1 32.4%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 246.1
bar=donor   line=cohort median 		302.3 281.6 38.6%
12 GNLY protein_coding 46.1
bar=donor   line=cohort median 		80.1 70.7 23.1%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 615.3
bar=donor   line=cohort median 		598.7 582.1 52.6%
14 HBA1 protein_coding 2,602.4
bar=donor   line=cohort median 		2,133.6 1,960.7 61.9%
15 HBA2 protein_coding 1,047.1
bar=donor   line=cohort median 		1,142.2 1,083.5 46.9%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 4,715.7
bar=donor   line=cohort median 		6,862.1 6,938.4 9.1%
17 MT-CO2 protein_coding 5,745.0
bar=donor   line=cohort median 		6,023.6 5,810.8 48.4%
18 MT-ND1 protein_coding 2,609.5
bar=donor   line=cohort median 		3,656.3 3,718.2 15.8%
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