GSM6881315

Dataset: gse221521 • Sample: DM group RNA409 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

11,247,766 Total counts Group median: 12,709,871 • 13.2%ile (↓ Low)
26,976 Detected genes Group median: 2,638 • 65.0%ile (≈ Median)
6 Mitochondrial fraction (%) Group median: 6 • 49.0%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

54.0Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.24
bar=donor   line=cohort median 		0.17 71.2%
FOXO3 Insulin/IGF-1 Signaling 11.98
bar=donor   line=cohort median 		12.92 39.6%
CETP Lipid Metabolism 0.57
bar=donor   line=cohort median 		0.40 79.0%
SIRT6 Sirtuin Family 3.61
bar=donor   line=cohort median 		3.67 44.8%
SIRT1 Sirtuin Family 3.87
bar=donor   line=cohort median 		3.48 67.1%
SIRT3 Sirtuin Family 1.28
bar=donor   line=cohort median 		1.10 75.9%
IGF1R Insulin/IGF-1 Signaling 5.15
bar=donor   line=cohort median 		4.33 64.5%
KLOTHO Anti-aging 0.07
bar=donor   line=cohort median 		0.06 52.1%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.05
bar=donor   line=cohort median 		0.07 44.3%
TERT Telomere Maintenance 0.03
bar=donor   line=cohort median 		0.01 75.4%
IRS2 Insulin/IGF-1 Signaling 21.32
bar=donor   line=cohort median 		35.28 20.0%
TP53 Tumor Suppression 4.52
bar=donor   line=cohort median 		3.83 68.1%
SHC1 Signal Transduction 8.76
bar=donor   line=cohort median 		8.77 49.0%
ACE Signal Transduction 0.17
bar=donor   line=cohort median 		0.39 11.1%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 10,660.3 68,705
2 MT-RNR2 ENSG00000210082 Mt_rRNA 9,038.2 158,488
3 MT-CO1 ENSG00000198804 protein_coding 6,689.3 116,020
4 MT-CO2 ENSG00000198712 protein_coding 5,714.1 43,961
5 MT-ND3 ENSG00000198840 protein_coding 5,262.2 20,479
6 MT-CO3 ENSG00000198938 protein_coding 4,902.9 43,235
7 MT-RNR1 ENSG00000211459 Mt_rRNA 4,803.0 51,538
8 FTL ENSG00000087086 protein_coding 4,018.9 39,372
9 AC005912.1 ENSG00000227081 processed_pseudogene 3,999.4 11,471
10 MT-ATP8 ENSG00000228253 protein_coding 3,983.6 9,275

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,687.9
bar=donor   line=cohort median 		1,568.6 1,385.4 60.9%
2 S100A9 protein_coding 10,660.3
bar=donor   line=cohort median 		10,144.6 9,235.1 60.4%
3 IL1B protein_coding 11.7
bar=donor   line=cohort median 		6.9 6.1 82.6%
4 CXCL8 protein_coding 384.4
bar=donor   line=cohort median 		225.8 207.4 78.5%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 8.1
bar=donor   line=cohort median 		2.2 2.4 90.9%
6 FCGR3B protein_coding 128.0
bar=donor   line=cohort median 		157.0 129.3 48.4%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 607.9
bar=donor   line=cohort median 		802.6 706.2 40.7%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 55.2
bar=donor   line=cohort median 		56.8 56.4 47.4%
9 CD3E protein_coding 29.3
bar=donor   line=cohort median 		36.9 37.7 24.1%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 5.2
bar=donor   line=cohort median 		3.2 3.1 84.2%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 136.7
bar=donor   line=cohort median 		296.3 281.6 9.6%
12 GNLY protein_coding 34.8
bar=donor   line=cohort median 		77.5 70.7 11.7%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 910.9
bar=donor   line=cohort median 		509.6 582.1 68.7%
14 HBA1 protein_coding 3,732.0
bar=donor   line=cohort median 		1,931.5 1,960.7 71.2%
15 HBA2 protein_coding 1,796.4
bar=donor   line=cohort median 		1,068.0 1,083.5 68.1%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 6,689.3
bar=donor   line=cohort median 		7,011.1 6,938.4 43.8%
17 MT-CO2 protein_coding 5,714.1
bar=donor   line=cohort median 		5,968.9 5,810.8 47.4%
18 MT-ND1 protein_coding 3,297.8
bar=donor   line=cohort median 		3,670.4 3,718.2 33.4%
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