GSM6881316

Dataset: gse221521 • Sample: DM group RNA41 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

13,323,590 Total counts Group median: 12,709,871 • 74.4%ile (≈ Median)
22,579 Detected genes Group median: 2,638 • 2.8%ile (↓ Low)
7 Mitochondrial fraction (%) Group median: 6 • 65.5%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

34.8Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.04
bar=donor   line=cohort median 		0.17 15.3%
FOXO3 Insulin/IGF-1 Signaling 11.27
bar=donor   line=cohort median 		12.92 33.4%
CETP Lipid Metabolism 0.51
bar=donor   line=cohort median 		0.40 70.2%
SIRT6 Sirtuin Family 5.08
bar=donor   line=cohort median 		3.67 93.5%
SIRT1 Sirtuin Family 2.35
bar=donor   line=cohort median 		3.48 3.4%
SIRT3 Sirtuin Family 0.58
bar=donor   line=cohort median 		1.10 1.3%
IGF1R Insulin/IGF-1 Signaling 0.58
bar=donor   line=cohort median 		4.33 6.5%
KLOTHO Anti-aging 0.17
bar=donor   line=cohort median 		0.06 92.5%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.00
bar=donor   line=cohort median 		0.07 10.4%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 22.85
bar=donor   line=cohort median 		35.28 22.0%
TP53 Tumor Suppression 2.94
bar=donor   line=cohort median 		3.83 20.5%
SHC1 Signal Transduction 9.29
bar=donor   line=cohort median 		8.77 67.1%
ACE Signal Transduction 0.21
bar=donor   line=cohort median 		0.39 18.9%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 27,281.3 208,277
2 MT-RNR2 ENSG00000210082 Mt_rRNA 15,090.4 313,450
3 FTL ENSG00000087086 protein_coding 8,601.8 99,822
4 MT-RNR1 ENSG00000211459 Mt_rRNA 8,422.2 107,052
5 MT-CO2 ENSG00000198712 protein_coding 6,510.0 59,328
6 MT-CO1 ENSG00000198804 protein_coding 5,576.3 114,565
7 MT-CO3 ENSG00000198938 protein_coding 5,239.9 54,734
8 HBA1 ENSG00000206172 protein_coding 4,556.5 104,420
9 MT-ND1 ENSG00000198888 protein_coding 4,056.2 51,665
10 MT-ND3 ENSG00000198840 protein_coding 3,145.8 14,502

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 2,807.6
bar=donor   line=cohort median 		1,568.6 1,385.4 92.5%
2 S100A9 protein_coding 27,281.3
bar=donor   line=cohort median 		10,144.6 9,235.1 99.2%
3 IL1B protein_coding 2.8
bar=donor   line=cohort median 		6.9 6.1 14.2%
4 CXCL8 protein_coding 127.1
bar=donor   line=cohort median 		225.8 207.4 26.7%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 10.4
bar=donor   line=cohort median 		2.2 2.4 95.6%
6 FCGR3B protein_coding 208.5
bar=donor   line=cohort median 		157.0 129.3 78.5%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,816.1
bar=donor   line=cohort median 		802.6 706.2 96.6%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 51.1
bar=donor   line=cohort median 		56.8 56.4 42.7%
9 CD3E protein_coding 29.2
bar=donor   line=cohort median 		36.9 37.7 23.1%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 1.4
bar=donor   line=cohort median 		3.2 3.1 7.5%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 244.6
bar=donor   line=cohort median 		296.3 281.6 37.0%
12 GNLY protein_coding 50.6
bar=donor   line=cohort median 		77.5 70.7 27.7%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 553.9
bar=donor   line=cohort median 		509.6 582.1 48.4%
14 HBA1 protein_coding 4,556.5
bar=donor   line=cohort median 		1,931.5 1,960.7 75.9%
15 HBA2 protein_coding 2,505.3
bar=donor   line=cohort median 		1,068.0 1,083.5 76.9%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 5,576.3
bar=donor   line=cohort median 		7,011.1 6,938.4 23.1%
17 MT-CO2 protein_coding 6,510.0
bar=donor   line=cohort median 		5,968.9 5,810.8 64.5%
18 MT-ND1 protein_coding 4,056.2
bar=donor   line=cohort median 		3,670.4 3,718.2 60.4%
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