GSM6881317

Dataset: gse221521 • Sample: DM group RNA418 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

12,694,219 Total counts Group median: 12,709,871 • 52.6%ile (≈ Median)
26,710 Detected genes Group median: 2,638 • 57.8%ile (≈ Median)
6 Mitochondrial fraction (%) Group median: 6 • 44.8%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

48.4Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.17
bar=donor   line=cohort median 		0.17 50.5%
FOXO3 Insulin/IGF-1 Signaling 9.85
bar=donor   line=cohort median 		12.92 20.0%
CETP Lipid Metabolism 0.43
bar=donor   line=cohort median 		0.40 58.8%
SIRT6 Sirtuin Family 3.70
bar=donor   line=cohort median 		3.67 51.0%
SIRT1 Sirtuin Family 3.34
bar=donor   line=cohort median 		3.48 40.2%
SIRT3 Sirtuin Family 1.08
bar=donor   line=cohort median 		1.10 47.9%
IGF1R Insulin/IGF-1 Signaling 4.86
bar=donor   line=cohort median 		4.33 59.3%
KLOTHO Anti-aging 0.13
bar=donor   line=cohort median 		0.06 83.2%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.00
bar=donor   line=cohort median 		0.07 10.4%
TERT Telomere Maintenance 0.03
bar=donor   line=cohort median 		0.01 68.1%
IRS2 Insulin/IGF-1 Signaling 24.42
bar=donor   line=cohort median 		35.28 25.7%
TP53 Tumor Suppression 4.78
bar=donor   line=cohort median 		3.83 73.3%
SHC1 Signal Transduction 8.30
bar=donor   line=cohort median 		8.77 33.4%
ACE Signal Transduction 0.43
bar=donor   line=cohort median 		0.39 56.2%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 14,091.1 102,496
2 MT-RNR2 ENSG00000210082 Mt_rRNA 7,347.3 145,406
3 MT-CO1 ENSG00000198804 protein_coding 6,938.4 135,815
4 MT-CO3 ENSG00000198938 protein_coding 6,271.0 62,411
5 FTL ENSG00000087086 protein_coding 5,173.1 57,197
6 MT-CO2 ENSG00000198712 protein_coding 5,111.1 44,379
7 MT-ND3 ENSG00000198840 protein_coding 4,371.8 19,202
8 MT-RNR1 ENSG00000211459 Mt_rRNA 4,143.5 50,179
9 MT-ND4 ENSG00000198886 protein_coding 3,883.1 67,926
10 MT-ND1 ENSG00000198888 protein_coding 3,874.0 47,014

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,842.0
bar=donor   line=cohort median 		1,568.6 1,385.4 70.2%
2 S100A9 protein_coding 14,091.1
bar=donor   line=cohort median 		10,144.6 9,235.1 78.5%
3 IL1B protein_coding 24.7
bar=donor   line=cohort median 		6.9 6.1 98.2%
4 CXCL8 protein_coding 144.6
bar=donor   line=cohort median 		225.8 207.4 30.3%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 8.2
bar=donor   line=cohort median 		2.2 2.4 91.5%
6 FCGR3B protein_coding 239.5
bar=donor   line=cohort median 		157.0 129.3 86.8%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 651.1
bar=donor   line=cohort median 		802.6 706.2 44.3%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 66.5
bar=donor   line=cohort median 		56.8 56.4 64.0%
9 CD3E protein_coding 41.1
bar=donor   line=cohort median 		36.9 37.7 60.4%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 4.7
bar=donor   line=cohort median 		3.2 3.1 78.5%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 190.1
bar=donor   line=cohort median 		296.3 281.6 22.5%
12 GNLY protein_coding 42.7
bar=donor   line=cohort median 		77.5 70.7 19.4%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 201.0
bar=donor   line=cohort median 		509.6 582.1 14.8%
14 HBA1 protein_coding 1,030.8
bar=donor   line=cohort median 		1,931.5 1,960.7 27.7%
15 HBA2 protein_coding 620.5
bar=donor   line=cohort median 		1,068.0 1,083.5 29.8%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 6,938.4
bar=donor   line=cohort median 		7,011.1 6,938.4 50.0%
17 MT-CO2 protein_coding 5,111.1
bar=donor   line=cohort median 		5,968.9 5,810.8 30.8%
18 MT-ND1 protein_coding 3,874.0
bar=donor   line=cohort median 		3,670.4 3,718.2 54.7%
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