GSM6881318

Dataset: gse221521 • Sample: Control group RNA419 • Status: Healthy control
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Quality Control Metrics

12,019,048 Total counts Group median: 12,762,148 • 27.7%ile (≈ Median)
26,996 Detected genes Group median: 2,606 • 65.5%ile (≈ Median)
6 Mitochondrial fraction (%) Group median: 6 • 51.6%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

49.4Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.20
bar=donor   line=cohort median 		0.17 60.4%
FOXO3 Insulin/IGF-1 Signaling 12.47
bar=donor   line=cohort median 		12.92 42.8%
CETP Lipid Metabolism 0.47
bar=donor   line=cohort median 		0.40 66.1%
SIRT6 Sirtuin Family 3.87
bar=donor   line=cohort median 		3.67 59.8%
SIRT1 Sirtuin Family 3.98
bar=donor   line=cohort median 		3.48 69.2%
SIRT3 Sirtuin Family 0.85
bar=donor   line=cohort median 		1.10 11.7%
IGF1R Insulin/IGF-1 Signaling 4.34
bar=donor   line=cohort median 		4.33 50.5%
KLOTHO Anti-aging 0.09
bar=donor   line=cohort median 		0.06 64.5%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.00
bar=donor   line=cohort median 		0.07 10.4%
TERT Telomere Maintenance 0.05
bar=donor   line=cohort median 		0.01 90.9%
IRS2 Insulin/IGF-1 Signaling 29.98
bar=donor   line=cohort median 		35.28 41.2%
TP53 Tumor Suppression 3.96
bar=donor   line=cohort median 		3.83 54.2%
SHC1 Signal Transduction 9.03
bar=donor   line=cohort median 		8.77 59.3%
ACE Signal Transduction 0.19
bar=donor   line=cohort median 		0.39 12.2%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 12,438.8 85,665
2 MT-RNR2 ENSG00000210082 Mt_rRNA 9,413.3 176,384
3 MT-CO2 ENSG00000198712 protein_coding 6,180.9 50,813
4 MT-CO1 ENSG00000198804 protein_coding 5,659.3 104,885
5 MT-ATP6 ENSG00000198899 protein_coding 5,552.9 45,450
6 MT-RNR1 ENSG00000211459 Mt_rRNA 4,930.4 56,533
7 AC005912.1 ENSG00000227081 processed_pseudogene 4,779.7 14,649
8 MT-CO3 ENSG00000198938 protein_coding 4,593.7 43,286
9 FTL ENSG00000087086 protein_coding 4,488.4 46,987
10 MT-ATP8 ENSG00000228253 protein_coding 4,400.0 10,947

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 2,589.8
bar=donor   line=cohort median 		1,535.8 1,385.4 88.9%
2 S100A9 protein_coding 12,438.8
bar=donor   line=cohort median 		10,851.3 9,235.1 72.3%
3 IL1B protein_coding 19.1
bar=donor   line=cohort median 		5.6 6.1 94.6%
4 CXCL8 protein_coding 162.8
bar=donor   line=cohort median 		220.4 207.4 34.5%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 6.7
bar=donor   line=cohort median 		1.7 2.4 85.8%
6 FCGR3B protein_coding 206.0
bar=donor   line=cohort median 		145.0 129.3 77.5%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 650.3
bar=donor   line=cohort median 		709.1 706.2 43.8%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 74.6
bar=donor   line=cohort median 		66.1 56.4 70.7%
9 CD3E protein_coding 37.4
bar=donor   line=cohort median 		37.6 37.7 49.5%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.8
bar=donor   line=cohort median 		3.1 3.1 40.2%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 427.4
bar=donor   line=cohort median 		302.3 281.6 81.1%
12 GNLY protein_coding 104.1
bar=donor   line=cohort median 		80.1 70.7 72.3%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 528.9
bar=donor   line=cohort median 		598.7 582.1 47.4%
14 HBA1 protein_coding 1,820.9
bar=donor   line=cohort median 		2,133.6 1,960.7 46.9%
15 HBA2 protein_coding 1,257.9
bar=donor   line=cohort median 		1,142.2 1,083.5 60.4%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 5,659.3
bar=donor   line=cohort median 		6,862.1 6,938.4 25.6%
17 MT-CO2 protein_coding 6,180.9
bar=donor   line=cohort median 		6,023.6 5,810.8 58.3%
18 MT-ND1 protein_coding 2,981.1
bar=donor   line=cohort median 		3,656.3 3,718.2 24.1%
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