GSM6881320

Dataset: gse221521 • Sample: Control group RNA425 • Status: Healthy control
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Quality Control Metrics

9,545,494 Total counts Group median: 12,762,148 • 1.8%ile (↓ Low)
25,936 Detected genes Group median: 2,606 • 31.9%ile (≈ Median)
5 Mitochondrial fraction (%) Group median: 6 • 21.5%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

47.5Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.22
bar=donor   line=cohort median 		0.17 68.1%
FOXO3 Insulin/IGF-1 Signaling 11.20
bar=donor   line=cohort median 		12.92 32.4%
CETP Lipid Metabolism 0.37
bar=donor   line=cohort median 		0.40 43.3%
SIRT6 Sirtuin Family 4.01
bar=donor   line=cohort median 		3.67 66.6%
SIRT1 Sirtuin Family 4.80
bar=donor   line=cohort median 		3.48 86.8%
SIRT3 Sirtuin Family 0.95
bar=donor   line=cohort median 		1.10 24.6%
IGF1R Insulin/IGF-1 Signaling 4.87
bar=donor   line=cohort median 		4.33 59.8%
KLOTHO Anti-aging 0.00
bar=donor   line=cohort median 		0.06 5.2%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.04
bar=donor   line=cohort median 		0.07 36.0%
TERT Telomere Maintenance 0.03
bar=donor   line=cohort median 		0.01 80.1%
IRS2 Insulin/IGF-1 Signaling 16.27
bar=donor   line=cohort median 		35.28 11.7%
TP53 Tumor Suppression 3.15
bar=donor   line=cohort median 		3.83 25.7%
SHC1 Signal Transduction 10.09
bar=donor   line=cohort median 		8.77 87.8%
ACE Signal Transduction 0.30
bar=donor   line=cohort median 		0.39 35.5%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 7,246.1 39,633
2 MT-RNR2 ENSG00000210082 Mt_rRNA 6,916.5 102,927
3 MT-CO1 ENSG00000198804 protein_coding 5,459.8 80,364
4 MT-CO2 ENSG00000198712 protein_coding 4,961.9 32,397
5 FTL ENSG00000087086 protein_coding 3,934.4 32,711
6 MT-ATP8 ENSG00000228253 protein_coding 3,785.1 7,479
7 MT-RNR1 ENSG00000211459 Mt_rRNA 3,740.2 34,060
8 MT-CO3 ENSG00000198938 protein_coding 3,722.5 27,858
9 MT-ND4L ENSG00000212907 protein_coding 3,140.0 8,902
10 MT-ND4 ENSG00000198886 protein_coding 2,999.3 39,452

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,168.9
bar=donor   line=cohort median 		1,535.8 1,385.4 35.0%
2 S100A9 protein_coding 7,246.1
bar=donor   line=cohort median 		10,851.3 9,235.1 34.5%
3 IL1B protein_coding 8.8
bar=donor   line=cohort median 		5.6 6.1 70.2%
4 CXCL8 protein_coding 101.9
bar=donor   line=cohort median 		220.4 207.4 20.5%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 2.4
bar=donor   line=cohort median 		1.7 2.4 51.0%
6 FCGR3B protein_coding 150.1
bar=donor   line=cohort median 		145.0 129.3 58.3%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 706.6
bar=donor   line=cohort median 		709.1 706.2 50.5%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 48.0
bar=donor   line=cohort median 		66.1 56.4 35.5%
9 CD3E protein_coding 23.1
bar=donor   line=cohort median 		37.6 37.7 10.1%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 7.8
bar=donor   line=cohort median 		3.1 3.1 92.5%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 178.3
bar=donor   line=cohort median 		302.3 281.6 20.5%
12 GNLY protein_coding 50.0
bar=donor   line=cohort median 		80.1 70.7 26.7%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 749.8
bar=donor   line=cohort median 		598.7 582.1 60.9%
14 HBA1 protein_coding 2,352.4
bar=donor   line=cohort median 		2,133.6 1,960.7 59.3%
15 HBA2 protein_coding 1,083.5
bar=donor   line=cohort median 		1,142.2 1,083.5 50.0%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 5,459.8
bar=donor   line=cohort median 		6,862.1 6,938.4 20.5%
17 MT-CO2 protein_coding 4,961.9
bar=donor   line=cohort median 		6,023.6 5,810.8 26.2%
18 MT-ND1 protein_coding 2,694.9
bar=donor   line=cohort median 		3,656.3 3,718.2 18.9%
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