GSM6881321

Dataset: gse221521 • Sample: DR group RNA431 • Status: Diabetic retinopathy
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Quality Control Metrics

9,068,724 Total counts Group median: 12,498,211 • 1.3%ile (↓ Low)
25,837 Detected genes Group median: 27,368 • 28.2%ile (≈ Median)
6 Mitochondrial fraction (%) Group median: 6 • 35.5%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

55.3Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.35
bar=donor   line=cohort median 		0.17 89.9%
FOXO3 Insulin/IGF-1 Signaling 19.05
bar=donor   line=cohort median 		12.92 92.5%
CETP Lipid Metabolism 0.29
bar=donor   line=cohort median 		0.40 24.6%
SIRT6 Sirtuin Family 4.53
bar=donor   line=cohort median 		3.67 83.2%
SIRT1 Sirtuin Family 3.48
bar=donor   line=cohort median 		3.48 50.5%
SIRT3 Sirtuin Family 1.15
bar=donor   line=cohort median 		1.10 56.7%
IGF1R Insulin/IGF-1 Signaling 6.79
bar=donor   line=cohort median 		4.33 86.3%
KLOTHO Anti-aging 0.00
bar=donor   line=cohort median 		0.06 5.2%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.00
bar=donor   line=cohort median 		0.07 10.4%
TERT Telomere Maintenance 0.04
bar=donor   line=cohort median 		0.01 81.6%
IRS2 Insulin/IGF-1 Signaling 63.33
bar=donor   line=cohort median 		35.28 83.7%
TP53 Tumor Suppression 2.12
bar=donor   line=cohort median 		3.83 2.9%
SHC1 Signal Transduction 8.75
bar=donor   line=cohort median 		8.77 47.9%
ACE Signal Transduction 0.49
bar=donor   line=cohort median 		0.39 65.5%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 15,937.3 82,816
2 MT-RNR2 ENSG00000210082 Mt_rRNA 8,834.2 124,899
3 MT-CO2 ENSG00000198712 protein_coding 6,289.9 39,016
4 MT-CO3 ENSG00000198938 protein_coding 5,586.6 39,720
5 FTL ENSG00000087086 protein_coding 5,346.0 42,227
6 MT-RNR1 ENSG00000211459 Mt_rRNA 5,306.1 45,906
7 MT-CO1 ENSG00000198804 protein_coding 4,415.3 61,744
8 MT-ND3 ENSG00000198840 protein_coding 4,147.8 13,015
9 MT-ND1 ENSG00000198888 protein_coding 3,876.8 33,611
10 AC005912.1 ENSG00000227081 processed_pseudogene 3,875.4 8,962

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 2,485.6
bar=donor   line=cohort median 		1,223.7 1,385.4 87.3%
2 S100A9 protein_coding 15,937.3
bar=donor   line=cohort median 		7,732.1 9,235.1 86.3%
3 IL1B protein_coding 4.3
bar=donor   line=cohort median 		4.9 6.1 31.3%
4 CXCL8 protein_coding 319.5
bar=donor   line=cohort median 		197.4 207.4 69.7%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 0.6
bar=donor   line=cohort median 		2.9 2.4 7.0%
6 FCGR3B protein_coding 157.8
bar=donor   line=cohort median 		108.9 129.3 60.9%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 527.4
bar=donor   line=cohort median 		581.4 706.2 31.9%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 83.8
bar=donor   line=cohort median 		51.6 56.4 80.1%
9 CD3E protein_coding 43.6
bar=donor   line=cohort median 		38.1 37.7 66.1%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.0
bar=donor   line=cohort median 		3.0 3.1 17.4%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 371.1
bar=donor   line=cohort median 		252.2 281.6 72.3%
12 GNLY protein_coding 108.1
bar=donor   line=cohort median 		58.9 70.7 75.9%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 772.9
bar=donor   line=cohort median 		585.0 582.1 62.4%
14 HBA1 protein_coding 2,816.4
bar=donor   line=cohort median 		1,960.4 1,960.7 63.5%
15 HBA2 protein_coding 1,577.5
bar=donor   line=cohort median 		1,080.5 1,083.5 64.0%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 4,415.3
bar=donor   line=cohort median 		6,740.9 6,938.4 7.5%
17 MT-CO2 protein_coding 6,289.9
bar=donor   line=cohort median 		5,693.7 5,810.8 61.9%
18 MT-ND1 protein_coding 3,876.8
bar=donor   line=cohort median 		3,876.8 3,718.2 55.2%
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