GSM6881322

Dataset: gse221521 • Sample: Control group RNA437 • Status: Healthy control
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Quality Control Metrics

9,624,615 Total counts Group median: 12,762,148 • 2.3%ile (↓ Low)
25,567 Detected genes Group median: 2,606 • 20.5%ile (↓ Low)
12 Mitochondrial fraction (%) Group median: 6 • 96.1%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

44.1Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.11
bar=donor   line=cohort median 		0.17 35.5%
FOXO3 Insulin/IGF-1 Signaling 10.60
bar=donor   line=cohort median 		12.92 25.7%
CETP Lipid Metabolism 0.47
bar=donor   line=cohort median 		0.40 65.0%
SIRT6 Sirtuin Family 3.72
bar=donor   line=cohort median 		3.67 52.1%
SIRT1 Sirtuin Family 3.10
bar=donor   line=cohort median 		3.48 31.4%
SIRT3 Sirtuin Family 1.31
bar=donor   line=cohort median 		1.10 81.1%
IGF1R Insulin/IGF-1 Signaling 1.70
bar=donor   line=cohort median 		4.33 14.8%
KLOTHO Anti-aging 0.02
bar=donor   line=cohort median 		0.06 18.9%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.15
bar=donor   line=cohort median 		0.07 83.2%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 56.05
bar=donor   line=cohort median 		35.28 76.9%
TP53 Tumor Suppression 3.39
bar=donor   line=cohort median 		3.83 32.9%
SHC1 Signal Transduction 8.50
bar=donor   line=cohort median 		8.77 40.7%
ACE Signal Transduction 0.31
bar=donor   line=cohort median 		0.39 36.5%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 22,832.9 342,602
2 MT-RNR1 ENSG00000211459 Mt_rRNA 17,210.0 158,020
3 HBA1 ENSG00000206172 protein_coding 11,259.2 186,389
4 MT-CO2 ENSG00000198712 protein_coding 11,011.3 72,490
5 MT-CO3 ENSG00000198938 protein_coding 9,168.4 69,182
6 MT-CO1 ENSG00000198804 protein_coding 8,339.3 123,765
7 MT-ND3 ENSG00000198840 protein_coding 7,873.6 26,220
8 MT-ND1 ENSG00000198888 protein_coding 6,729.4 61,918
9 MT-ND2 ENSG00000198763 protein_coding 5,530.7 55,467
10 AC005912.1 ENSG00000227081 processed_pseudogene 5,473.3 13,433

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 859.7
bar=donor   line=cohort median 		1,535.8 1,385.4 16.3%
2 S100A9 protein_coding 4,992.5
bar=donor   line=cohort median 		10,851.3 9,235.1 15.8%
3 IL1B protein_coding 0.9
bar=donor   line=cohort median 		5.6 6.1 6.0%
4 CXCL8 protein_coding 86.4
bar=donor   line=cohort median 		220.4 207.4 15.8%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 0.5
bar=donor   line=cohort median 		1.7 2.4 6.0%
6 FCGR3B protein_coding 69.4
bar=donor   line=cohort median 		145.0 129.3 18.4%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 151.1
bar=donor   line=cohort median 		709.1 706.2 0.8%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 84.5
bar=donor   line=cohort median 		66.1 56.4 80.6%
9 CD3E protein_coding 52.3
bar=donor   line=cohort median 		37.6 37.7 79.5%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 1.8
bar=donor   line=cohort median 		3.1 3.1 14.8%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 815.4
bar=donor   line=cohort median 		302.3 281.6 99.2%
12 GNLY protein_coding 280.8
bar=donor   line=cohort median 		80.1 70.7 99.7%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 2,071.8
bar=donor   line=cohort median 		598.7 582.1 92.5%
14 HBA1 protein_coding 11,259.2
bar=donor   line=cohort median 		2,133.6 1,960.7 95.6%
15 HBA2 protein_coding 5,356.0
bar=donor   line=cohort median 		1,142.2 1,083.5 93.5%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 8,339.3
bar=donor   line=cohort median 		6,862.1 6,938.4 72.8%
17 MT-CO2 protein_coding 11,011.3
bar=donor   line=cohort median 		6,023.6 5,810.8 95.6%
18 MT-ND1 protein_coding 6,729.4
bar=donor   line=cohort median 		3,656.3 3,718.2 93.0%
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