GSM6881323

Dataset: gse221521 • Sample: DR group RNA44 • Status: Diabetic retinopathy
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Quality Control Metrics

12,434,829 Total counts Group median: 12,498,211 • 42.2%ile (≈ Median)
25,616 Detected genes Group median: 27,368 • 23.1%ile (↓ Low)
9 Mitochondrial fraction (%) Group median: 6 • 90.4%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

51.3Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.13
bar=donor   line=cohort median 		0.17 40.7%
FOXO3 Insulin/IGF-1 Signaling 14.72
bar=donor   line=cohort median 		12.92 62.4%
CETP Lipid Metabolism 0.99
bar=donor   line=cohort median 		0.40 97.7%
SIRT6 Sirtuin Family 3.11
bar=donor   line=cohort median 		3.67 21.5%
SIRT1 Sirtuin Family 3.85
bar=donor   line=cohort median 		3.48 66.6%
SIRT3 Sirtuin Family 1.15
bar=donor   line=cohort median 		1.10 58.3%
IGF1R Insulin/IGF-1 Signaling 5.43
bar=donor   line=cohort median 		4.33 68.1%
KLOTHO Anti-aging 0.06
bar=donor   line=cohort median 		0.06 47.4%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.00
bar=donor   line=cohort median 		0.07 10.4%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 63.15
bar=donor   line=cohort median 		35.28 83.2%
TP53 Tumor Suppression 3.87
bar=donor   line=cohort median 		3.83 51.0%
SHC1 Signal Transduction 8.84
bar=donor   line=cohort median 		8.77 52.6%
ACE Signal Transduction 0.34
bar=donor   line=cohort median 		0.39 42.8%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 14,554.3 282,149
2 MT-RNR1 ENSG00000211459 Mt_rRNA 10,831.1 128,487
3 HBA1 ENSG00000206172 protein_coding 10,194.3 218,035
4 MT-CO1 ENSG00000198804 protein_coding 8,976.8 172,126
5 MT-CO3 ENSG00000198938 protein_coding 8,968.6 87,434
6 MT-CO2 ENSG00000198712 protein_coding 8,831.0 75,111
7 TMSB4XP8 ENSG00000187653 processed_pseudogene 8,538.7 14,334
8 S100A9 ENSG00000163220 protein_coding 7,770.2 55,364
9 HBA2 ENSG00000188536 protein_coding 7,056.9 148,125
10 MT-ND1 ENSG00000198888 protein_coding 6,421.8 76,341

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,399.4
bar=donor   line=cohort median 		1,223.7 1,385.4 50.5%
2 S100A9 protein_coding 7,770.2
bar=donor   line=cohort median 		7,732.1 9,235.1 38.6%
3 IL1B protein_coding 2.2
bar=donor   line=cohort median 		4.9 6.1 10.1%
4 CXCL8 protein_coding 150.9
bar=donor   line=cohort median 		197.4 207.4 31.9%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 16.8
bar=donor   line=cohort median 		2.9 2.4 98.7%
6 FCGR3B protein_coding 125.4
bar=donor   line=cohort median 		108.9 129.3 46.4%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 504.9
bar=donor   line=cohort median 		581.4 706.2 28.2%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 100.1
bar=donor   line=cohort median 		51.6 56.4 87.3%
9 CD3E protein_coding 70.7
bar=donor   line=cohort median 		38.1 37.7 90.9%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.2
bar=donor   line=cohort median 		3.0 3.1 25.1%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 429.4
bar=donor   line=cohort median 		252.2 281.6 81.6%
12 GNLY protein_coding 80.8
bar=donor   line=cohort median 		58.9 70.7 57.8%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 3,316.4
bar=donor   line=cohort median 		585.0 582.1 97.2%
14 HBA1 protein_coding 10,194.3
bar=donor   line=cohort median 		1,960.4 1,960.7 93.5%
15 HBA2 protein_coding 7,056.9
bar=donor   line=cohort median 		1,080.5 1,083.5 96.1%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 8,976.8
bar=donor   line=cohort median 		6,740.9 6,938.4 83.2%
17 MT-CO2 protein_coding 8,831.0
bar=donor   line=cohort median 		5,693.7 5,810.8 85.2%
18 MT-ND1 protein_coding 6,421.8
bar=donor   line=cohort median 		3,876.8 3,718.2 92.0%
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