GSM6881324

Dataset: gse221521 • Sample: Control group RNA441 • Status: Healthy control
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Quality Control Metrics

12,898,543 Total counts Group median: 12,762,148 • 61.4%ile (≈ Median)
24,738 Detected genes Group median: 2,606 • 10.6%ile (↓ Low)
12 Mitochondrial fraction (%) Group median: 6 • 97.2%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

45.0Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.53
bar=donor   line=cohort median 		0.17 97.7%
FOXO3 Insulin/IGF-1 Signaling 4.60
bar=donor   line=cohort median 		12.92 3.4%
CETP Lipid Metabolism 0.95
bar=donor   line=cohort median 		0.40 96.6%
SIRT6 Sirtuin Family 3.29
bar=donor   line=cohort median 		3.67 28.2%
SIRT1 Sirtuin Family 2.50
bar=donor   line=cohort median 		3.48 8.6%
SIRT3 Sirtuin Family 1.64
bar=donor   line=cohort median 		1.10 96.6%
IGF1R Insulin/IGF-1 Signaling 1.57
bar=donor   line=cohort median 		4.33 13.2%
KLOTHO Anti-aging 0.00
bar=donor   line=cohort median 		0.06 5.2%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.23
bar=donor   line=cohort median 		0.07 92.0%
TERT Telomere Maintenance 0.02
bar=donor   line=cohort median 		0.01 55.7%
IRS2 Insulin/IGF-1 Signaling 7.65
bar=donor   line=cohort median 		35.28 3.9%
TP53 Tumor Suppression 3.67
bar=donor   line=cohort median 		3.83 44.3%
SHC1 Signal Transduction 7.49
bar=donor   line=cohort median 		8.77 10.1%
ACE Signal Transduction 0.51
bar=donor   line=cohort median 		0.39 71.8%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 23,181.5 466,153
2 MT-RNR1 ENSG00000211459 Mt_rRNA 16,423.1 202,090
3 MT-CO2 ENSG00000198712 protein_coding 12,098.1 106,737
4 MT-CO3 ENSG00000198938 protein_coding 11,945.0 120,793
5 MT-ND1 ENSG00000198888 protein_coding 9,919.1 122,312
6 HBA1 ENSG00000206172 protein_coding 9,313.5 206,625
7 MT-CO1 ENSG00000198804 protein_coding 8,561.9 170,293
8 RPS28P7 ENSG00000227097 processed_pseudogene 7,570.8 20,507
9 MT-ND3 ENSG00000198840 protein_coding 7,422.3 33,125
10 MT-ND2 ENSG00000198763 protein_coding 5,976.4 80,324

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 395.2
bar=donor   line=cohort median 		1,535.8 1,385.4 4.4%
2 S100A9 protein_coding 2,193.2
bar=donor   line=cohort median 		10,851.3 9,235.1 3.9%
3 IL1B protein_coding 0.2
bar=donor   line=cohort median 		5.6 6.1 0.8%
4 CXCL8 protein_coding 26.8
bar=donor   line=cohort median 		220.4 207.4 4.4%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 0.5
bar=donor   line=cohort median 		1.7 2.4 5.4%
6 FCGR3B protein_coding 9.4
bar=donor   line=cohort median 		145.0 129.3 1.3%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 75.5
bar=donor   line=cohort median 		709.1 706.2 0.3%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 137.9
bar=donor   line=cohort median 		66.1 56.4 97.7%
9 CD3E protein_coding 99.8
bar=donor   line=cohort median 		37.6 37.7 98.7%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 5.3
bar=donor   line=cohort median 		3.1 3.1 84.7%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 690.7
bar=donor   line=cohort median 		302.3 281.6 96.6%
12 GNLY protein_coding 168.6
bar=donor   line=cohort median 		80.1 70.7 93.0%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 1,476.4
bar=donor   line=cohort median 		598.7 582.1 84.7%
14 HBA1 protein_coding 9,313.5
bar=donor   line=cohort median 		2,133.6 1,960.7 91.5%
15 HBA2 protein_coding 5,205.9
bar=donor   line=cohort median 		1,142.2 1,083.5 93.0%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 8,561.9
bar=donor   line=cohort median 		6,862.1 6,938.4 78.0%
17 MT-CO2 protein_coding 12,098.1
bar=donor   line=cohort median 		6,023.6 5,810.8 97.2%
18 MT-ND1 protein_coding 9,919.1
bar=donor   line=cohort median 		3,656.3 3,718.2 98.7%
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