GSM6881326

Dataset: gse221521 • Sample: DM group RNA442 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

12,580,449 Total counts Group median: 12,709,871 • 49.5%ile (≈ Median)
26,254 Detected genes Group median: 2,638 • 41.7%ile (≈ Median)
14 Mitochondrial fraction (%) Group median: 6 • 98.7%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

40.2Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.32
bar=donor   line=cohort median 		0.17 84.7%
FOXO3 Insulin/IGF-1 Signaling 4.25
bar=donor   line=cohort median 		12.92 2.9%
CETP Lipid Metabolism 0.47
bar=donor   line=cohort median 		0.40 65.5%
SIRT6 Sirtuin Family 3.26
bar=donor   line=cohort median 		3.67 26.7%
SIRT1 Sirtuin Family 2.76
bar=donor   line=cohort median 		3.48 18.4%
SIRT3 Sirtuin Family 1.17
bar=donor   line=cohort median 		1.10 60.9%
IGF1R Insulin/IGF-1 Signaling 2.54
bar=donor   line=cohort median 		4.33 28.2%
KLOTHO Anti-aging 0.02
bar=donor   line=cohort median 		0.06 20.5%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.14
bar=donor   line=cohort median 		0.07 82.6%
TERT Telomere Maintenance 0.01
bar=donor   line=cohort median 		0.01 44.8%
IRS2 Insulin/IGF-1 Signaling 24.91
bar=donor   line=cohort median 		35.28 27.2%
TP53 Tumor Suppression 1.73
bar=donor   line=cohort median 		3.83 1.8%
SHC1 Signal Transduction 7.55
bar=donor   line=cohort median 		8.77 11.1%
ACE Signal Transduction 0.58
bar=donor   line=cohort median 		0.39 79.0%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 26,596.5 521,635
2 MT-RNR1 ENSG00000211459 Mt_rRNA 19,144.4 229,766
3 HBA1 ENSG00000206172 protein_coding 17,085.3 369,698
4 MT-CO2 ENSG00000198712 protein_coding 11,909.6 102,482
5 MT-ND3 ENSG00000198840 protein_coding 10,543.7 45,895
6 MT-CO3 ENSG00000198938 protein_coding 9,806.8 96,725
7 MT-CO1 ENSG00000198804 protein_coding 9,465.5 183,621
8 MT-ND1 ENSG00000198888 protein_coding 9,358.8 112,558
9 HBA2 ENSG00000188536 protein_coding 8,570.1 181,993
10 AC005912.1 ENSG00000227081 processed_pseudogene 7,127.5 22,865

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 639.9
bar=donor   line=cohort median 		1,568.6 1,385.4 10.6%
2 S100A9 protein_coding 3,334.9
bar=donor   line=cohort median 		10,144.6 9,235.1 9.6%
3 IL1B protein_coding 0.6
bar=donor   line=cohort median 		6.9 6.1 2.8%
4 CXCL8 protein_coding 25.3
bar=donor   line=cohort median 		225.8 207.4 3.9%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 0.9
bar=donor   line=cohort median 		2.2 2.4 15.3%
6 FCGR3B protein_coding 29.6
bar=donor   line=cohort median 		157.0 129.3 8.0%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 370.2
bar=donor   line=cohort median 		802.6 706.2 16.3%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 122.3
bar=donor   line=cohort median 		56.8 56.4 93.5%
9 CD3E protein_coding 73.7
bar=donor   line=cohort median 		36.9 37.7 92.0%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.2
bar=donor   line=cohort median 		3.2 3.1 52.6%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 557.9
bar=donor   line=cohort median 		296.3 281.6 92.5%
12 GNLY protein_coding 135.9
bar=donor   line=cohort median 		77.5 70.7 87.3%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 2,786.8
bar=donor   line=cohort median 		509.6 582.1 95.1%
14 HBA1 protein_coding 17,085.3
bar=donor   line=cohort median 		1,931.5 1,960.7 98.7%
15 HBA2 protein_coding 8,570.1
bar=donor   line=cohort median 		1,068.0 1,083.5 97.7%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 9,465.5
bar=donor   line=cohort median 		7,011.1 6,938.4 88.9%
17 MT-CO2 protein_coding 11,909.6
bar=donor   line=cohort median 		5,968.9 5,810.8 96.6%
18 MT-ND1 protein_coding 9,358.8
bar=donor   line=cohort median 		3,670.4 3,718.2 97.7%
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