GSM6881328

Dataset: gse221521 • Sample: DM group RNA454 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

10,153,418 Total counts Group median: 12,709,871 • 5.4%ile (↓ Low)
25,576 Detected genes Group median: 2,638 • 21.5%ile (↓ Low)
6 Mitochondrial fraction (%) Group median: 6 • 36.5%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

40.4Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.34
bar=donor   line=cohort median 		0.17 87.3%
FOXO3 Insulin/IGF-1 Signaling 15.00
bar=donor   line=cohort median 		12.92 64.5%
CETP Lipid Metabolism 0.23
bar=donor   line=cohort median 		0.40 13.2%
SIRT6 Sirtuin Family 4.27
bar=donor   line=cohort median 		3.67 76.9%
SIRT1 Sirtuin Family 2.91
bar=donor   line=cohort median 		3.48 23.1%
SIRT3 Sirtuin Family 0.70
bar=donor   line=cohort median 		1.10 4.9%
IGF1R Insulin/IGF-1 Signaling 2.21
bar=donor   line=cohort median 		4.33 21.0%
KLOTHO Anti-aging 0.06
bar=donor   line=cohort median 		0.06 44.3%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.10
bar=donor   line=cohort median 		0.07 69.2%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 70.34
bar=donor   line=cohort median 		35.28 89.4%
TP53 Tumor Suppression 2.60
bar=donor   line=cohort median 		3.83 13.2%
SHC1 Signal Transduction 7.89
bar=donor   line=cohort median 		8.77 17.4%
ACE Signal Transduction 0.19
bar=donor   line=cohort median 		0.39 14.3%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 17,010.8 98,967
2 MT-RNR2 ENSG00000210082 Mt_rRNA 8,115.1 128,455
3 MT-CO1 ENSG00000198804 protein_coding 6,616.8 103,597
4 MT-CO2 ENSG00000198712 protein_coding 6,596.2 45,810
5 FTL ENSG00000087086 protein_coding 5,838.6 51,634
6 MT-CO3 ENSG00000198938 protein_coding 5,414.1 43,098
7 MT-RNR1 ENSG00000211459 Mt_rRNA 4,406.3 42,681
8 MT-ND4 ENSG00000198886 protein_coding 3,479.0 48,676
9 MT-ATP8 ENSG00000228253 protein_coding 3,126.4 6,571
10 MT-ND3 ENSG00000198840 protein_coding 3,062.8 10,760

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 2,899.1
bar=donor   line=cohort median 		1,568.6 1,385.4 93.5%
2 S100A9 protein_coding 17,010.8
bar=donor   line=cohort median 		10,144.6 9,235.1 89.4%
3 IL1B protein_coding 9.0
bar=donor   line=cohort median 		6.9 6.1 71.8%
4 CXCL8 protein_coding 349.7
bar=donor   line=cohort median 		225.8 207.4 75.4%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 2.9
bar=donor   line=cohort median 		2.2 2.4 60.9%
6 FCGR3B protein_coding 188.5
bar=donor   line=cohort median 		157.0 129.3 72.8%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,002.7
bar=donor   line=cohort median 		802.6 706.2 72.8%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 48.6
bar=donor   line=cohort median 		56.8 56.4 36.5%
9 CD3E protein_coding 26.5
bar=donor   line=cohort median 		36.9 37.7 16.8%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.0
bar=donor   line=cohort median 		3.2 3.1 16.3%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 333.4
bar=donor   line=cohort median 		296.3 281.6 65.5%
12 GNLY protein_coding 97.4
bar=donor   line=cohort median 		77.5 70.7 68.1%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 377.0
bar=donor   line=cohort median 		509.6 582.1 30.3%
14 HBA1 protein_coding 2,321.1
bar=donor   line=cohort median 		1,931.5 1,960.7 57.8%
15 HBA2 protein_coding 1,218.9
bar=donor   line=cohort median 		1,068.0 1,083.5 58.3%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 6,616.8
bar=donor   line=cohort median 		7,011.1 6,938.4 42.7%
17 MT-CO2 protein_coding 6,596.2
bar=donor   line=cohort median 		5,968.9 5,810.8 66.1%
18 MT-ND1 protein_coding 2,864.8
bar=donor   line=cohort median 		3,670.4 3,718.2 22.0%
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