GSM6881329

Dataset: gse221521 • Sample: Control group RNA455 • Status: Healthy control
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Quality Control Metrics

10,949,840 Total counts Group median: 12,762,148 • 9.6%ile (↓ Low)
26,453 Detected genes Group median: 2,606 • 48.4%ile (≈ Median)
7 Mitochondrial fraction (%) Group median: 6 • 67.6%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

58.7Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.65
bar=donor   line=cohort median 		0.17 99.2%
FOXO3 Insulin/IGF-1 Signaling 24.03
bar=donor   line=cohort median 		12.92 99.2%
CETP Lipid Metabolism 0.28
bar=donor   line=cohort median 		0.40 22.5%
SIRT6 Sirtuin Family 4.35
bar=donor   line=cohort median 		3.67 80.1%
SIRT1 Sirtuin Family 3.48
bar=donor   line=cohort median 		3.48 49.5%
SIRT3 Sirtuin Family 1.07
bar=donor   line=cohort median 		1.10 44.8%
IGF1R Insulin/IGF-1 Signaling 1.69
bar=donor   line=cohort median 		4.33 14.3%
KLOTHO Anti-aging 0.12
bar=donor   line=cohort median 		0.06 82.1%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.29
bar=donor   line=cohort median 		0.07 95.6%
TERT Telomere Maintenance 0.06
bar=donor   line=cohort median 		0.01 93.0%
IRS2 Insulin/IGF-1 Signaling 80.48
bar=donor   line=cohort median 		35.28 94.6%
TP53 Tumor Suppression 2.39
bar=donor   line=cohort median 		3.83 7.0%
SHC1 Signal Transduction 8.03
bar=donor   line=cohort median 		8.77 23.1%
ACE Signal Transduction 0.25
bar=donor   line=cohort median 		0.39 27.7%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 11,890.2 74,602
2 MT-RNR2 ENSG00000210082 Mt_rRNA 11,077.1 189,095
3 MT-CO2 ENSG00000198712 protein_coding 7,261.4 54,386
4 MT-CO1 ENSG00000198804 protein_coding 6,838.5 115,465
5 MT-CO3 ENSG00000198938 protein_coding 5,900.2 50,651
6 MT-RNR1 ENSG00000211459 Mt_rRNA 5,651.7 59,038
7 FTL ENSG00000087086 protein_coding 5,632.5 53,719
8 HBA1 ENSG00000206172 protein_coding 5,401.7 101,735
9 MT-ND3 ENSG00000198840 protein_coding 5,037.7 19,086
10 MT-ATP8 ENSG00000228253 protein_coding 4,712.8 10,682

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 2,297.0
bar=donor   line=cohort median 		1,535.8 1,385.4 83.2%
2 S100A9 protein_coding 11,890.2
bar=donor   line=cohort median 		10,851.3 9,235.1 67.1%
3 IL1B protein_coding 1.5
bar=donor   line=cohort median 		5.6 6.1 7.0%
4 CXCL8 protein_coding 291.9
bar=donor   line=cohort median 		220.4 207.4 64.0%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.0
bar=donor   line=cohort median 		1.7 2.4 15.8%
6 FCGR3B protein_coding 177.5
bar=donor   line=cohort median 		145.0 129.3 68.1%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,322.3
bar=donor   line=cohort median 		709.1 706.2 86.3%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 70.0
bar=donor   line=cohort median 		66.1 56.4 67.1%
9 CD3E protein_coding 33.7
bar=donor   line=cohort median 		37.6 37.7 37.0%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.2
bar=donor   line=cohort median 		3.1 3.1 52.1%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 229.6
bar=donor   line=cohort median 		302.3 281.6 32.4%
12 GNLY protein_coding 72.0
bar=donor   line=cohort median 		80.1 70.7 50.5%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 1,089.1
bar=donor   line=cohort median 		598.7 582.1 73.8%
14 HBA1 protein_coding 5,401.7
bar=donor   line=cohort median 		2,133.6 1,960.7 81.1%
15 HBA2 protein_coding 2,924.4
bar=donor   line=cohort median 		1,142.2 1,083.5 80.6%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 6,838.5
bar=donor   line=cohort median 		6,862.1 6,938.4 46.4%
17 MT-CO2 protein_coding 7,261.4
bar=donor   line=cohort median 		6,023.6 5,810.8 71.2%
18 MT-ND1 protein_coding 3,884.5
bar=donor   line=cohort median 		3,656.3 3,718.2 55.7%
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